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B0BNB9

- B0BNB9_RAT

UniProt

B0BNB9 - B0BNB9_RAT

Protein
Submitted name:

HtrA serine peptidase 2

Gene

Htra2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro
    2. serine-type peptidase activity Source: RGD

    GO - Biological processi

    1. adult walking behavior Source: Ensembl
    2. cellular response to growth factor stimulus Source: Ensembl
    3. cellular response to heat Source: Ensembl
    4. ceramide metabolic process Source: RGD
    5. forebrain development Source: Ensembl
    6. intrinsic apoptotic signaling pathway Source: Ensembl
    7. mitochondrion organization Source: Ensembl
    8. negative regulation of cell death Source: RGD
    9. neuron development Source: Ensembl
    10. pentacyclic triterpenoid metabolic process Source: RGD
    11. positive regulation of apoptotic process Source: RGD
    12. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    13. positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    14. regulation of multicellular organism growth Source: Ensembl
    15. response to herbicide Source: RGD

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    HtrA serine peptidase 2Imported
    Submitted name:
    Protein Htra2Imported
    Submitted name:
    RCG56292, isoform CRA_dImported
    Gene namesi
    Name:Htra2Imported
    ORF Names:rCG_56292Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi1308906. Htra2.

    Subcellular locationi

    GO - Cellular componenti

    1. CD40 receptor complex Source: Ensembl
    2. cytoplasmic side of plasma membrane Source: Ensembl
    3. cytosol Source: RGD
    4. mitochondrial intermembrane space Source: Ensembl
    5. mitochondrion Source: RGD
    6. nucleus Source: Ensembl

    Expressioni

    Gene expression databases

    GenevestigatoriB0BNB9.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000030076.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG0265.
    GeneTreeiENSGT00510000046315.
    HOGENOMiHOG000223641.
    HOVERGENiHBG052044.
    KOiK08669.
    OMAiLIHRVIM.
    OrthoDBiEOG7V1FR7.
    TreeFamiTF323480.

    Family and domain databases

    Gene3Di2.30.42.10. 1 hit.
    InterProiIPR001478. PDZ.
    IPR001940. Peptidase_S1C.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF13180. PDZ_2. 1 hit.
    [Graphical view]
    PRINTSiPR00834. PROTEASES2C.
    SMARTiSM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 1 hit.
    SSF50494. SSF50494. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B0BNB9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAALKAGRGA NWSLRAWRAL GGIFWRKGPL LAPDLRALLT SGTPDPQARM    50
    TYGTPSLPAR VPLGVLASRA NLTSGTPDLW VRLTVGTPGS SDQEDCGSPG 100
    SRRREWLAVA LGAGGAVLLL LWGWGRGPST VLAAVPAPPP TSPRSQYNFI 150
    ADVVEKTAPA VVYIEILDRH PFSGREVPIS NGSGFIVASD GLIVTNAHVV 200
    ADRRRVRVRL PSGDTYEAMV TAVDPVADIA TLRIQTKEPL PTLPLGRSAD 250
    VRQGEFVVAM GSPFALQNTI TSGIVSSAQR PARDLGLPQT NVEYIQTDAA 300
    IDFGNSGGPL VNLDGEVIGV NTMKVTAGIS FAIPSDRLRE FLHRGEKKNS 350
    WFGISGSQRR YIGVMMLTLT PSILAELQLR EPSFPDVQHG VLIHKVILGS 400
    PAHRAGLRPA DVILAIGEKM IQNAEDVYEA VRTQSQLAVR IRRGPETLTL 450
    YVTPEVTE 458
    Length:458
    Mass (Da):49,094
    Last modified:February 26, 2008 - v1
    Checksum:i6DF2003B6D1C0B9E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06032014 Genomic DNA. No translation available.
    BC158760 mRNA. Translation: AAI58761.1.
    CH473957 Genomic DNA. Translation: EDL91109.1.
    RefSeqiNP_001100069.1. NM_001106599.2.
    UniGeneiRn.107325.

    Genome annotation databases

    EnsembliENSRNOT00000037333; ENSRNOP00000030076; ENSRNOG00000022448.
    GeneIDi297376.
    KEGGirno:297376.
    UCSCiRGD:1308906. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06032014 Genomic DNA. No translation available.
    BC158760 mRNA. Translation: AAI58761.1 .
    CH473957 Genomic DNA. Translation: EDL91109.1 .
    RefSeqi NP_001100069.1. NM_001106599.2.
    UniGenei Rn.107325.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000030076.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000037333 ; ENSRNOP00000030076 ; ENSRNOG00000022448 .
    GeneIDi 297376.
    KEGGi rno:297376.
    UCSCi RGD:1308906. rat.

    Organism-specific databases

    CTDi 27429.
    RGDi 1308906. Htra2.

    Phylogenomic databases

    eggNOGi COG0265.
    GeneTreei ENSGT00510000046315.
    HOGENOMi HOG000223641.
    HOVERGENi HBG052044.
    KOi K08669.
    OMAi LIHRVIM.
    OrthoDBi EOG7V1FR7.
    TreeFami TF323480.

    Miscellaneous databases

    NextBioi 642134.
    PROi B0BNB9.

    Gene expression databases

    Genevestigatori B0BNB9.

    Family and domain databases

    Gene3Di 2.30.42.10. 1 hit.
    InterProi IPR001478. PDZ.
    IPR001940. Peptidase_S1C.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF13180. PDZ_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00834. PROTEASES2C.
    SMARTi SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 1 hit.
    SSF50494. SSF50494. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: HeartImported.
    2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    5. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiB0BNB9_RAT
    AccessioniPrimary (citable) accession number: B0BNB9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 26, 2008
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3