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Protein
Submitted name:

HtrA serine peptidase 2

Gene

Htra2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • serine-type endopeptidase activity Source: Ensembl
  • serine-type peptidase activity Source: RGD

GO - Biological processi

Complete GO annotation...

Protein family/group databases

MEROPSiS01.278.

Names & Taxonomyi

Protein namesi
Submitted name:
HtrA serine peptidase 2Imported
Submitted name:
Protein Htra2Imported
Submitted name:
RCG56292, isoform CRA_dImported
Gene namesi
Name:Htra2Imported
ORF Names:rCG_56292Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1308906. Htra2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei106 – 12520HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • CD40 receptor complex Source: Ensembl
  • chromatin Source: Ensembl
  • cytoplasmic side of plasma membrane Source: Ensembl
  • cytoskeleton Source: Ensembl
  • cytosol Source: RGD
  • mitochondrial intermembrane space Source: Ensembl
  • mitochondrion Source: RGD
  • nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSRNOG00000022448.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030076.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini350 – 44596PDZ (DHR)InterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1320. Eukaryota.
COG0265. LUCA.
GeneTreeiENSGT00510000046315.
HOGENOMiHOG000223641.
HOVERGENiHBG052044.
KOiK08669.
OMAiRCIASPV.
OrthoDBiEOG091G0LXR.
TreeFamiTF323480.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR009003. Peptidase_S1_PA.
IPR001940. Peptidase_S1C.
[Graphical view]
PfamiPF13180. PDZ_2. 1 hit.
[Graphical view]
PRINTSiPR00834. PROTEASES2C.
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50494. SSF50494. 1 hit.

Sequencei

Sequence statusi: Complete.

B0BNB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALKAGRGA NWSLRAWRAL GGIFWRKGPL LAPDLRALLT SGTPDPQARM
60 70 80 90 100
TYGTPSLPAR VPLGVLASRA NLTSGTPDLW VRLTVGTPGS SDQEDCGSPG
110 120 130 140 150
SRRREWLAVA LGAGGAVLLL LWGWGRGPST VLAAVPAPPP TSPRSQYNFI
160 170 180 190 200
ADVVEKTAPA VVYIEILDRH PFSGREVPIS NGSGFIVASD GLIVTNAHVV
210 220 230 240 250
ADRRRVRVRL PSGDTYEAMV TAVDPVADIA TLRIQTKEPL PTLPLGRSAD
260 270 280 290 300
VRQGEFVVAM GSPFALQNTI TSGIVSSAQR PARDLGLPQT NVEYIQTDAA
310 320 330 340 350
IDFGNSGGPL VNLDGEVIGV NTMKVTAGIS FAIPSDRLRE FLHRGEKKNS
360 370 380 390 400
WFGISGSQRR YIGVMMLTLT PSILAELQLR EPSFPDVQHG VLIHKVILGS
410 420 430 440 450
PAHRAGLRPA DVILAIGEKM IQNAEDVYEA VRTQSQLAVR IRRGPETLTL

YVTPEVTE
Length:458
Mass (Da):49,094
Last modified:February 26, 2008 - v1
Checksum:i6DF2003B6D1C0B9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC130866 Genomic DNA. No translation available.
BC158760 mRNA. Translation: AAI58761.1.
CH473957 Genomic DNA. Translation: EDL91109.1.
RefSeqiNP_001100069.1. NM_001106599.2.
UniGeneiRn.107325.

Genome annotation databases

EnsembliENSRNOT00000037333; ENSRNOP00000030076; ENSRNOG00000022448.
GeneIDi297376.
KEGGirno:297376.
UCSCiRGD:1308906. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC130866 Genomic DNA. No translation available.
BC158760 mRNA. Translation: AAI58761.1.
CH473957 Genomic DNA. Translation: EDL91109.1.
RefSeqiNP_001100069.1. NM_001106599.2.
UniGeneiRn.107325.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030076.

Protein family/group databases

MEROPSiS01.278.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000037333; ENSRNOP00000030076; ENSRNOG00000022448.
GeneIDi297376.
KEGGirno:297376.
UCSCiRGD:1308906. rat.

Organism-specific databases

CTDi27429.
RGDi1308906. Htra2.

Phylogenomic databases

eggNOGiKOG1320. Eukaryota.
COG0265. LUCA.
GeneTreeiENSGT00510000046315.
HOGENOMiHOG000223641.
HOVERGENiHBG052044.
KOiK08669.
OMAiRCIASPV.
OrthoDBiEOG091G0LXR.
TreeFamiTF323480.

Gene expression databases

BgeeiENSRNOG00000022448.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR009003. Peptidase_S1_PA.
IPR001940. Peptidase_S1C.
[Graphical view]
PfamiPF13180. PDZ_2. 1 hit.
[Graphical view]
PRINTSiPR00834. PROTEASES2C.
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50494. SSF50494. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB0BNB9_RAT
AccessioniPrimary (citable) accession number: B0BNB9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 26, 2008
Last sequence update: February 26, 2008
Last modified: September 7, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.