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B0BNB9

- B0BNB9_RAT

UniProt

B0BNB9 - B0BNB9_RAT

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Protein
Submitted name:

HtrA serine peptidase 2

Gene

Htra2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
  2. serine-type peptidase activity Source: RGD

GO - Biological processi

  1. adult walking behavior Source: Ensembl
  2. cellular response to growth factor stimulus Source: Ensembl
  3. cellular response to heat Source: Ensembl
  4. ceramide metabolic process Source: RGD
  5. forebrain development Source: Ensembl
  6. intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
  7. mitochondrion organization Source: Ensembl
  8. negative regulation of cell death Source: RGD
  9. neuron development Source: Ensembl
  10. pentacyclic triterpenoid metabolic process Source: RGD
  11. positive regulation of apoptotic process Source: RGD
  12. positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Source: Ensembl
  13. positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  14. regulation of multicellular organism growth Source: Ensembl
  15. response to herbicide Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
HtrA serine peptidase 2Imported
Submitted name:
Protein Htra2Imported
Submitted name:
RCG56292, isoform CRA_dImported
Gene namesi
Name:Htra2Imported
ORF Names:rCG_56292Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi1308906. Htra2.

Subcellular locationi

GO - Cellular componenti

  1. CD40 receptor complex Source: Ensembl
  2. cytoplasmic side of plasma membrane Source: Ensembl
  3. cytosol Source: RGD
  4. mitochondrial intermembrane space Source: Ensembl
  5. mitochondrion Source: RGD
  6. nucleus Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriB0BNB9.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030076.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0265.
GeneTreeiENSGT00510000046315.
HOGENOMiHOG000223641.
HOVERGENiHBG052044.
KOiK08669.
OMAiLIHRVIM.
OrthoDBiEOG7V1FR7.
TreeFamiTF323480.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR001940. Peptidase_S1C.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF13180. PDZ_2. 1 hit.
[Graphical view]
PRINTSiPR00834. PROTEASES2C.
SMARTiSM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50494. SSF50494. 1 hit.

Sequencei

Sequence statusi: Complete.

B0BNB9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAALKAGRGA NWSLRAWRAL GGIFWRKGPL LAPDLRALLT SGTPDPQARM
60 70 80 90 100
TYGTPSLPAR VPLGVLASRA NLTSGTPDLW VRLTVGTPGS SDQEDCGSPG
110 120 130 140 150
SRRREWLAVA LGAGGAVLLL LWGWGRGPST VLAAVPAPPP TSPRSQYNFI
160 170 180 190 200
ADVVEKTAPA VVYIEILDRH PFSGREVPIS NGSGFIVASD GLIVTNAHVV
210 220 230 240 250
ADRRRVRVRL PSGDTYEAMV TAVDPVADIA TLRIQTKEPL PTLPLGRSAD
260 270 280 290 300
VRQGEFVVAM GSPFALQNTI TSGIVSSAQR PARDLGLPQT NVEYIQTDAA
310 320 330 340 350
IDFGNSGGPL VNLDGEVIGV NTMKVTAGIS FAIPSDRLRE FLHRGEKKNS
360 370 380 390 400
WFGISGSQRR YIGVMMLTLT PSILAELQLR EPSFPDVQHG VLIHKVILGS
410 420 430 440 450
PAHRAGLRPA DVILAIGEKM IQNAEDVYEA VRTQSQLAVR IRRGPETLTL

YVTPEVTE
Length:458
Mass (Da):49,094
Last modified:February 26, 2008 - v1
Checksum:i6DF2003B6D1C0B9E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06032014 Genomic DNA. No translation available.
BC158760 mRNA. Translation: AAI58761.1.
CH473957 Genomic DNA. Translation: EDL91109.1.
RefSeqiNP_001100069.1. NM_001106599.2.
UniGeneiRn.107325.

Genome annotation databases

EnsembliENSRNOT00000037333; ENSRNOP00000030076; ENSRNOG00000022448.
GeneIDi297376.
KEGGirno:297376.
UCSCiRGD:1308906. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AABR06032014 Genomic DNA. No translation available.
BC158760 mRNA. Translation: AAI58761.1 .
CH473957 Genomic DNA. Translation: EDL91109.1 .
RefSeqi NP_001100069.1. NM_001106599.2.
UniGenei Rn.107325.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000030076.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000037333 ; ENSRNOP00000030076 ; ENSRNOG00000022448 .
GeneIDi 297376.
KEGGi rno:297376.
UCSCi RGD:1308906. rat.

Organism-specific databases

CTDi 27429.
RGDi 1308906. Htra2.

Phylogenomic databases

eggNOGi COG0265.
GeneTreei ENSGT00510000046315.
HOGENOMi HOG000223641.
HOVERGENi HBG052044.
KOi K08669.
OMAi LIHRVIM.
OrthoDBi EOG7V1FR7.
TreeFami TF323480.

Miscellaneous databases

NextBioi 642134.
PROi B0BNB9.

Gene expression databases

Genevestigatori B0BNB9.

Family and domain databases

Gene3Di 2.30.42.10. 1 hit.
InterProi IPR001478. PDZ.
IPR001940. Peptidase_S1C.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF13180. PDZ_2. 1 hit.
[Graphical view ]
PRINTSi PR00834. PROTEASES2C.
SMARTi SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 1 hit.
SSF50494. SSF50494. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: HeartImported.
  2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.

Entry informationi

Entry nameiB0BNB9_RAT
AccessioniPrimary (citable) accession number: B0BNB9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 26, 2008
Last sequence update: February 26, 2008
Last modified: October 29, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3