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Protein

26S proteasome non-ATPase regulatory subunit 13

Gene

Psmd13

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-1169091. Activation of NF-kappaB in B cells.
R-RNO-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-RNO-1236978. Cross-presentation of soluble exogenous antigens (endosomes).
R-RNO-174084. Autodegradation of Cdh1 by Cdh1:APC/C.
R-RNO-174113. SCF-beta-TrCP mediated degradation of Emi1.
R-RNO-174154. APC/C:Cdc20 mediated degradation of Securin.
R-RNO-174178. APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
R-RNO-174184. Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
R-RNO-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-RNO-195253. Degradation of beta-catenin by the destruction complex.
R-RNO-202424. Downstream TCR signaling.
R-RNO-2467813. Separation of Sister Chromatids.
R-RNO-2871837. FCERI mediated NF-kB activation.
R-RNO-349425. Autodegradation of the E3 ubiquitin ligase COP1.
R-RNO-350562. Regulation of ornithine decarboxylase (ODC).
R-RNO-382556. ABC-family proteins mediated transport.
R-RNO-446652. Interleukin-1 family signaling.
R-RNO-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.
R-RNO-4608870. Asymmetric localization of PCP proteins.
R-RNO-4641257. Degradation of AXIN.
R-RNO-4641258. Degradation of DVL.
R-RNO-5358346. Hedgehog ligand biogenesis.
R-RNO-5607761. Dectin-1 mediated noncanonical NF-kB signaling.
R-RNO-5607764. CLEC7A (Dectin-1) signaling.
R-RNO-5610780. Degradation of GLI1 by the proteasome.
R-RNO-5610785. GLI3 is processed to GLI3R by the proteasome.
R-RNO-5632684. Hedgehog 'on' state.
R-RNO-5658442. Regulation of RAS by GAPs.
R-RNO-5668541. TNFR2 non-canonical NF-kB pathway.
R-RNO-5676590. NIK-->noncanonical NF-kB signaling.
R-RNO-5687128. MAPK6/MAPK4 signaling.
R-RNO-5689603. UCH proteinases.
R-RNO-5689880. Ub-specific processing proteases.
R-RNO-6798695. Neutrophil degranulation.
R-RNO-68827. CDT1 association with the CDC6:ORC:origin complex.
R-RNO-68949. Orc1 removal from chromatin.
R-RNO-69017. CDK-mediated phosphorylation and removal of Cdc6.
R-RNO-69229. Ubiquitin-dependent degradation of Cyclin D1.
R-RNO-69481. G2/M Checkpoints.
R-RNO-69601. Ubiquitin Mediated Degradation of Phosphorylated Cdc25A.
R-RNO-8852276. The role of GTSE1 in G2/M progression after G2 checkpoint.
R-RNO-8854050. FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
R-RNO-8939236. RUNX1 regulates transcription of genes involved in differentiation of HSCs.
R-RNO-8939902. Regulation of RUNX2 expression and activity.
R-RNO-8941858. Regulation of RUNX3 expression and activity.
R-RNO-8948751. Regulation of PTEN stability and activity.
R-RNO-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
26S proteasome non-ATPase regulatory subunit 13By similarityImported
Alternative name(s):
26S proteasome regulatory subunit RPN9
26S proteasome regulatory subunit S11By similarity
26S proteasome regulatory subunit p40.5By similarity
Gene namesi
Name:Psmd13Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1305236. Psmd13.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003712281 – 37626S proteasome non-ATPase regulatory subunit 13Add BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei298N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiB0BN93.
PeptideAtlasiB0BN93.
PRIDEiB0BN93.

2D gel databases

World-2DPAGEi0004:B0BN93.

PTM databases

iPTMnetiB0BN93.
PhosphoSitePlusiB0BN93.

Expressioni

Gene expression databases

BgeeiENSRNOG00000014109.
GenevisibleiB0BN93. RN.

Interactioni

Subunit structurei

Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.By similarity

Protein-protein interaction databases

BioGridi265335. 3 interactors.
IntActiB0BN93. 1 interactor.
STRINGi10116.ENSRNOP00000019642.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini171 – 338PCIPROSITE-ProRule annotationAdd BLAST168

Sequence similaritiesi

Belongs to the proteasome subunit S11 family.Sequence analysis

Phylogenomic databases

eggNOGiKOG2908. Eukaryota.
ENOG410XPG9. LUCA.
GeneTreeiENSGT00390000001802.
HOGENOMiHOG000216633.
InParanoidiB0BN93.
KOiK03039.
OMAiKFADKIN.
OrthoDBiEOG091G0977.
PhylomeDBiB0BN93.
TreeFamiTF105612.

Family and domain databases

InterProiView protein in InterPro
IPR000717. PCI_dom.
IPR035298. PSMD13.
IPR036390. WH_DNA-bd_sf.
PANTHERiPTHR10539. PTHR10539. 1 hit.
PfamiView protein in Pfam
PF01399. PCI. 1 hit.
SMARTiView protein in SMART
SM00088. PINT. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS50250. PCI. 1 hit.

Sequencei

Sequence statusi: Complete.

B0BN93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDVPAFLQQ SQSSGPGQAA VWHRLEELYT KKLWHQLTLQ VLDFVQDPCF
60 70 80 90 100
AQGDGLIKLY ENFISEFEHR VNPLSLVEII LHVVRQMTDP NVALTFLEKT
110 120 130 140 150
REKVKSSDEA VILCKTAIGA LKLNIGDLQA TKETIEDVEE MLNNLPGVTS
160 170 180 190 200
VHSRFYDLSS KYYQTIGNHA SYYKDALRFL GCVDIKDLPV SEQQERAFTL
210 220 230 240 250
GLAGLLGEGV FNFGELLMHP VLESLRNTDR QWLIDTLYAF NSGDVDRFQT
260 270 280 290 300
LKSAWGQQPD LAANEAQLLR KIQLLCLMEM TFTRPANHRQ LTFEEIAKSA
310 320 330 340 350
KITVNKVELL VMKALSVGLV RGSIDEVDKR VHMTWVQPRV LDLQQIKGMK
360 370
DRLELWCTDV KSMELLVEHQ AQDILT
Length:376
Mass (Da):42,817
Last modified:February 26, 2008 - v1
Checksum:iD49192C945BC7AF3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473953 Genomic DNA. Translation: EDM11946.1.
BC158732 mRNA. Translation: AAI58733.1.
RefSeqiNP_001102395.1. NM_001108925.2.
UniGeneiRn.16918.

Genome annotation databases

EnsembliENSRNOT00000019642; ENSRNOP00000019642; ENSRNOG00000014109.
GeneIDi365388.
KEGGirno:365388.
UCSCiRGD:1305236. rat.

Similar proteinsi

Entry informationi

Entry nameiPSD13_RAT
AccessioniPrimary (citable) accession number: B0BN93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: February 26, 2008
Last modified: November 22, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families