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Protein

Protein SGT1 homolog

Gene

Sugt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-RNO-844456. The NLRP3 inflammasome.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SGT1 homologBy similarity
Alternative name(s):
Suppressor of G2 allele of SKP1 homologBy similarity
Gene namesi
Name:Sugt1Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1307550. Sugt1.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Translocates the to nucleus upon heat shock, requiring S100A6.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 336335Protein SGT1 homologBy similarityPRO_0000330902Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei252 – 2521PhosphoserineBy similarity
Modified residuei255 – 2551PhosphothreonineBy similarity
Cross-linki266 – 266Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki266 – 266Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei302 – 3021PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated at Ser-252 and Ser-302, dephosphorylation promotes nuclear translocation, most likely due to disruption of the SUGT1-HSP90 complex.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiB0BN85.
PeptideAtlasiB0BN85.
PRIDEiB0BN85.

PTM databases

iPTMnetiB0BN85.

Expressioni

Gene expression databases

ExpressionAtlasiB0BN85. baseline and differential.
GenevisibleiB0BN85. RN.

Interactioni

Subunit structurei

Probably associates with SCF (SKP1-CUL1-F-box protein) complex through interaction with SKP1. Interacts with S100A6. Interacts with HSP90 (By similarity).By similarity

Protein-protein interaction databases

BioGridi253191. 1 interaction.
STRINGi10116.ENSRNOP00000017086.

Structurei

3D structure databases

ProteinModelPortaliB0BN85.
SMRiB0BN85. Positions 141-232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 4434TPR 1Add
BLAST
Repeati45 – 7834TPR 2Add
BLAST
Repeati79 – 11234TPR 3Add
BLAST
Domaini140 – 22990CSPROSITE-ProRule annotationAdd
BLAST
Domaini247 – 33690SGSPROSITE-ProRule annotationAdd
BLAST

Domaini

The CS domain mediates interaction with HSP90.By similarity

Sequence similaritiesi

Belongs to the SGT1 family.Curated
Contains 1 CS domain.PROSITE-ProRule annotation
Contains 1 SGS domain.PROSITE-ProRule annotation
Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0548. Eukaryota.
KOG1309. Eukaryota.
COG5091. LUCA.
GeneTreeiENSGT00390000013700.
HOGENOMiHOG000248210.
HOVERGENiHBG055080.
InParanoidiB0BN85.
KOiK12795.
OMAiILLGKYC.
OrthoDBiEOG7WX0B4.
PhylomeDBiB0BN85.
TreeFamiTF105979.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
2.60.40.790. 1 hit.
InterProiIPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
IPR007699. SGS_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF04969. CS. 1 hit.
PF05002. SGS. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 2 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF49764. SSF49764. 1 hit.
PROSITEiPS51203. CS. 1 hit.
PS51048. SGS. 1 hit.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B0BN85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAAGPAS SQRFFQSFPD ALIDGDPQAA LEELTKALEQ NPDDAQYYCQ
60 70 80 90 100
RAYCHILLGK YCDGIADVKK SLELNPNNST ALLRKGICEY YEKDYASALE
110 120 130 140 150
TFAEGQKLDG TDTNFDIWIK RCQEIQNGSE PEVSASQRTQ SKIKYDWYQT
160 170 180 190 200
ESHVIITLMI KNVQKNDVRV DFSEKELSAV VKIPSGEDCS LKLRLLHPII
210 220 230 240 250
PEQSTFKVLS TKIEIKMKKP EAVRWEKLEG QGDVPAPKQF TADVKNMYPS
260 270 280 290 300
SSHYTRNWDK LVGEIKEEEK NEKLEGDAAL NKLFQQIYSD GSDEVKRAMN
310 320 330
KSFMESGGTV LSTNWSDVGK RKVEINPPDD MEWKQY
Length:336
Mass (Da):38,091
Last modified:February 26, 2008 - v1
Checksum:i8C4C4014113AEB9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC158724 mRNA. Translation: AAI58725.1.
RefSeqiNP_001013069.1. NM_001013051.1.
UniGeneiRn.101758.

Genome annotation databases

EnsembliENSRNOT00000017086; ENSRNOP00000017086; ENSRNOG00000012594.
GeneIDi290408.
KEGGirno:290408.
UCSCiRGD:1307550. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC158724 mRNA. Translation: AAI58725.1.
RefSeqiNP_001013069.1. NM_001013051.1.
UniGeneiRn.101758.

3D structure databases

ProteinModelPortaliB0BN85.
SMRiB0BN85. Positions 141-232.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi253191. 1 interaction.
STRINGi10116.ENSRNOP00000017086.

PTM databases

iPTMnetiB0BN85.

Proteomic databases

PaxDbiB0BN85.
PeptideAtlasiB0BN85.
PRIDEiB0BN85.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000017086; ENSRNOP00000017086; ENSRNOG00000012594.
GeneIDi290408.
KEGGirno:290408.
UCSCiRGD:1307550. rat.

Organism-specific databases

CTDi10910.
RGDi1307550. Sugt1.

Phylogenomic databases

eggNOGiKOG0548. Eukaryota.
KOG1309. Eukaryota.
COG5091. LUCA.
GeneTreeiENSGT00390000013700.
HOGENOMiHOG000248210.
HOVERGENiHBG055080.
InParanoidiB0BN85.
KOiK12795.
OMAiILLGKYC.
OrthoDBiEOG7WX0B4.
PhylomeDBiB0BN85.
TreeFamiTF105979.

Enzyme and pathway databases

ReactomeiR-RNO-844456. The NLRP3 inflammasome.

Miscellaneous databases

PROiB0BN85.

Gene expression databases

ExpressionAtlasiB0BN85. baseline and differential.
GenevisibleiB0BN85. RN.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
2.60.40.790. 1 hit.
InterProiIPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
IPR007699. SGS_dom.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF04969. CS. 1 hit.
PF05002. SGS. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 2 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF49764. SSF49764. 1 hit.
PROSITEiPS51203. CS. 1 hit.
PS51048. SGS. 1 hit.
PS50005. TPR. 3 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiSGT1_RAT
AccessioniPrimary (citable) accession number: B0BN85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: February 26, 2008
Last modified: July 6, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.