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Protein

Protein SGT1 homolog

Gene

Sugt1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-RNO-844456 The NLRP3 inflammasome

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SGT1 homologBy similarity
Alternative name(s):
Suppressor of G2 allele of SKP1 homologBy similarity
Gene namesi
Name:Sugt1Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi1307550 Sugt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003309022 – 336Protein SGT1 homologBy similarityAdd BLAST335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei252PhosphoserineBy similarity1
Modified residuei255PhosphothreonineBy similarity1
Cross-linki266Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki266Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei302PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated at Ser-252 and Ser-302, dephosphorylation promotes nuclear translocation, most likely due to disruption of the SUGT1-HSP90 complex.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiB0BN85
PeptideAtlasiB0BN85
PRIDEiB0BN85

PTM databases

iPTMnetiB0BN85
PhosphoSitePlusiB0BN85

Expressioni

Gene expression databases

BgeeiENSRNOG00000012594
ExpressionAtlasiB0BN85 baseline and differential
GenevisibleiB0BN85 RN

Interactioni

Subunit structurei

Probably associates with SCF (SKP1-CUL1-F-box protein) complex through interaction with SKP1. Interacts with S100A6. Interacts with HSP90 (By similarity).By similarity

Protein-protein interaction databases

BioGridi253191, 1 interactor
STRINGi10116.ENSRNOP00000017086

Structurei

3D structure databases

ProteinModelPortaliB0BN85
SMRiB0BN85
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 44TPR 1Add BLAST34
Repeati45 – 78TPR 2Add BLAST34
Repeati79 – 112TPR 3Add BLAST34
Domaini140 – 229CSPROSITE-ProRule annotationAdd BLAST90
Domaini247 – 336SGSPROSITE-ProRule annotationAdd BLAST90

Domaini

The CS domain mediates interaction with HSP90.By similarity

Sequence similaritiesi

Belongs to the SGT1 family.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0548 Eukaryota
KOG1309 Eukaryota
COG5091 LUCA
GeneTreeiENSGT00390000013700
HOGENOMiHOG000248210
HOVERGENiHBG055080
InParanoidiB0BN85
KOiK12795
OMAiWIKRCEE
OrthoDBiEOG091G0QQH
PhylomeDBiB0BN85
TreeFamiTF105979

Family and domain databases

Gene3Di1.25.40.10, 1 hit
2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR007052 CS_dom
IPR008978 HSP20-like_chaperone
IPR007699 SGS_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF04969 CS, 1 hit
PF05002 SGS, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 2 hits
SUPFAMiSSF48452 SSF48452, 1 hit
SSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS51203 CS, 1 hit
PS51048 SGS, 1 hit
PS50005 TPR, 3 hits
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B0BN85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAAGPAS SQRFFQSFPD ALIDGDPQAA LEELTKALEQ NPDDAQYYCQ
60 70 80 90 100
RAYCHILLGK YCDGIADVKK SLELNPNNST ALLRKGICEY YEKDYASALE
110 120 130 140 150
TFAEGQKLDG TDTNFDIWIK RCQEIQNGSE PEVSASQRTQ SKIKYDWYQT
160 170 180 190 200
ESHVIITLMI KNVQKNDVRV DFSEKELSAV VKIPSGEDCS LKLRLLHPII
210 220 230 240 250
PEQSTFKVLS TKIEIKMKKP EAVRWEKLEG QGDVPAPKQF TADVKNMYPS
260 270 280 290 300
SSHYTRNWDK LVGEIKEEEK NEKLEGDAAL NKLFQQIYSD GSDEVKRAMN
310 320 330
KSFMESGGTV LSTNWSDVGK RKVEINPPDD MEWKQY
Length:336
Mass (Da):38,091
Last modified:February 26, 2008 - v1
Checksum:i8C4C4014113AEB9A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC158724 mRNA Translation: AAI58725.1
RefSeqiNP_001013069.1, NM_001013051.1
UniGeneiRn.101758

Genome annotation databases

EnsembliENSRNOT00000017086; ENSRNOP00000017086; ENSRNOG00000012594
GeneIDi290408
KEGGirno:290408
UCSCiRGD:1307550 rat

Similar proteinsi

Entry informationi

Entry nameiSGT1_RAT
AccessioniPrimary (citable) accession number: B0BN85
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: February 26, 2008
Last modified: April 25, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health