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Protein

Prefoldin subunit 2

Gene

Pfdn2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 2
Gene namesi
Name:Pfdn2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1591406 Pfdn2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003303601 – 154Prefoldin subunit 2Add BLAST154

Proteomic databases

PaxDbiB0BN18
PeptideAtlasiB0BN18
PRIDEiB0BN18

PTM databases

iPTMnetiB0BN18
PhosphoSitePlusiB0BN18

Expressioni

Gene expression databases

BgeeiENSRNOG00000003983
GenevisibleiB0BN18 RN

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Binds to c-Myc; interacts with its N-terminal domain. Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth-dependent manner (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005346

Structurei

3D structure databases

ProteinModelPortaliB0BN18
SMRiB0BN18
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit beta family.Curated

Phylogenomic databases

eggNOGiKOG4098 Eukaryota
ENOG4111S6I LUCA
GeneTreeiENSGT00390000009272
HOGENOMiHOG000211843
HOVERGENiHBG008172
InParanoidiB0BN18
KOiK09549
OMAiDPERKCF
OrthoDBiEOG091G11OU
PhylomeDBiB0BN18
TreeFamiTF313252

Family and domain databases

Gene3Di1.10.287.370, 1 hit
InterProiView protein in InterPro
IPR027235 PFD2
IPR002777 PFD_beta-like
IPR009053 Prefoldin
PANTHERiPTHR13303 PTHR13303, 1 hit
PfamiView protein in Pfam
PF01920 Prefoldin_2, 1 hit

Sequencei

Sequence statusi: Complete.

B0BN18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSSGRVGK SGGSGTGKGA VSAEQVIAGF NRLRQEQRGL ASKAAELEME
60 70 80 90 100
LNEHSLVIDT LKEVDETRKC YRMVGGVLVE RTVKEVLPAL EGNKEQIQKI
110 120 130 140 150
IETLSQQLQA KGKELNEFRE KHNIRLMGED EKPAAKENSE GAGAKSSSAG

VLVS
Length:154
Mass (Da):16,580
Last modified:February 26, 2008 - v1
Checksum:iAE949993A9AD6715
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC158649 mRNA Translation: AAI58650.1
RefSeqiNP_001102946.1, NM_001109476.1
UniGeneiRn.7627

Genome annotation databases

EnsembliENSRNOT00000005346; ENSRNOP00000005346; ENSRNOG00000003983
GeneIDi685607
KEGGirno:685607
UCSCiRGD:1591406 rat

Similar proteinsi

Entry informationi

Entry nameiPFD2_RAT
AccessioniPrimary (citable) accession number: B0BN18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: February 26, 2008
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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