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Protein

Prefoldin subunit 2

Gene

Pfdn2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 2
Gene namesi
Name:Pfdn2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi1591406. Pfdn2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003303601 – 154Prefoldin subunit 2Add BLAST154

Proteomic databases

PaxDbiB0BN18.
PeptideAtlasiB0BN18.
PRIDEiB0BN18.

PTM databases

iPTMnetiB0BN18.
PhosphoSitePlusiB0BN18.

Expressioni

Gene expression databases

BgeeiENSRNOG00000003983.
GenevisibleiB0BN18. RN.

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Binds to c-Myc; interacts with its N-terminal domain. Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth-dependent manner (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005346.

Structurei

3D structure databases

ProteinModelPortaliB0BN18.
SMRiB0BN18.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit beta family.Curated

Phylogenomic databases

eggNOGiKOG4098. Eukaryota.
ENOG4111S6I. LUCA.
GeneTreeiENSGT00390000009272.
HOGENOMiHOG000211843.
HOVERGENiHBG008172.
InParanoidiB0BN18.
KOiK09549.
OMAiDPERKCF.
OrthoDBiEOG091G11OU.
PhylomeDBiB0BN18.
TreeFamiTF313252.

Family and domain databases

InterProiView protein in InterPro
IPR027235. PFD2.
IPR002777. PFD_beta-like.
PANTHERiPTHR13303. PTHR13303. 1 hit.
PfamiView protein in Pfam
PF01920. Prefoldin_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B0BN18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSSGRVGK SGGSGTGKGA VSAEQVIAGF NRLRQEQRGL ASKAAELEME
60 70 80 90 100
LNEHSLVIDT LKEVDETRKC YRMVGGVLVE RTVKEVLPAL EGNKEQIQKI
110 120 130 140 150
IETLSQQLQA KGKELNEFRE KHNIRLMGED EKPAAKENSE GAGAKSSSAG

VLVS
Length:154
Mass (Da):16,580
Last modified:February 26, 2008 - v1
Checksum:iAE949993A9AD6715
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC158649 mRNA. Translation: AAI58650.1.
RefSeqiNP_001102946.1. NM_001109476.1.
UniGeneiRn.7627.

Genome annotation databases

EnsembliENSRNOT00000005346; ENSRNOP00000005346; ENSRNOG00000003983.
GeneIDi685607.
KEGGirno:685607.
UCSCiRGD:1591406. rat.

Similar proteinsi

Entry informationi

Entry nameiPFD2_RAT
AccessioniPrimary (citable) accession number: B0BN18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: February 26, 2008
Last modified: November 22, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families