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Protein
Submitted name:

Dihydrofolate reductase

Gene

Dhfr

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Dihydrofolate reductaseImported
Submitted name:
RCG44522Imported
Gene namesi
Name:DhfrImported
ORF Names:rCG_44522Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi2500 Dhfr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiB0BMV8

Expressioni

Gene expression databases

BgeeiENSRNOG00000013521
ExpressionAtlasiB0BMV8 baseline and differential

Structurei

3D structure databases

SMRiB0BMV8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 185DHFRInterPro annotationAdd BLAST182

Sequence similaritiesi

Belongs to the dihydrofolate reductase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1324 Eukaryota
COG0262 LUCA
HOVERGENiHBG000773
KOiK00287
OMAiRDNQLPW
OrthoDBiEOG091G0PRK

Family and domain databases

CDDicd00209 DHFR, 1 hit
Gene3Di3.40.430.10, 1 hit
InterProiView protein in InterPro
IPR024072 DHFR-like_dom_sf
IPR017925 DHFR_CS
IPR001796 DHFR_dom
PfamiView protein in Pfam
PF00186 DHFR_1, 1 hit
SUPFAMiSSF53597 SSF53597, 1 hit
PROSITEiView protein in PROSITE
PS00075 DHFR_1, 1 hit
PS51330 DHFR_2, 1 hit

Sequencei

Sequence statusi: Complete.

B0BMV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRPLNCIVA VSQNMGIGKN GDLPWPLLRN EFKYFQRMTT TSSVEGKQNL
60 70 80 90 100
VIMGRKTWFS IPEKNRPLKD RINIVLSREL KEPPQGAHFL AKSLDDALKL
110 120 130 140 150
IEQPELASKV DMVWVVGGSS VYQEAMNQPG HLRLFVTRIM QEFESDTFFP
160 170 180
EIDLEKYKLL PEYPGVLSEI QEEKGIKYKF EVYEKKD
Length:187
Mass (Da):21,638
Last modified:February 26, 2008 - v1
Checksum:iFE1DB4F3515F8B26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC158583 mRNA Translation: AAI58584.1
CH473955 Genomic DNA Translation: EDM10015.1
RefSeqiNP_569084.1, NM_130400.2
UniGeneiRn.233753
Rn.24681

Genome annotation databases

GeneIDi24312
KEGGirno:24312

Similar proteinsi

Entry informationi

Entry nameiB0BMV8_RAT
AccessioniPrimary (citable) accession number: B0BMV8
Entry historyiIntegrated into UniProtKB/TrEMBL: February 26, 2008
Last sequence update: February 26, 2008
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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