Reviewed, UniProtKB/Swiss-Prot B0BML7 (SPRE_XENTR)

Names and origin

Protein names

Recommended name:
    Sepiapterin reductase
      Short name=SPR
    EC=1.1.1.153

Gene names

Name:

spr

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin By similarity.
Catalytic activity	7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH. Tetrahydrobiopterin + 2 NADP+ = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 NADPH.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the sepiapterin reductase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tetrahydrobiopterin biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro sepiapterin reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 261	261	Sepiapterin reductase		PRO_0000327644

Sequences

	Sequence		Length	Mass (Da)
	B0BML7-1 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: 124DB39935624B1F	FASTA	261	28,359
	10 20 30 40 50 60 MAATGALGSV LCVLTGASRG FGRTLAHLLC PRLLPGSTLL LVSRTEEALK GLAGELAHKY 70 80 90 100 110 120 PGVRVRWEAA DLGTSEGVSA AVRAAGELQV GAAQKLLIIN NAGSIGDVSK MFVDFSDPKE 130 140 150 160 170 180 VTDYMMFNVS SPLCLTASLL KTFPRRPDLQ RVVVNVSSLA ALQPFKSWAL YCSGKAARDM 190 200 210 220 230 240 IFRVLAEEEK DVRVLNYAPG PLDTDMHVVA RTQTADPELR RFLMDRKEKG KMVDIQVSAK 250 260 KMLDLLEADA YKSGDHIDFF D

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC158483 mRNA. Translation: AAI58484.1.
RefSeq	NP_001120067.1.
UniGene	Str.64931
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	100145068.
KEGG	xtr:100145068.
Organism-specific databases
Xenbase	XB-FEAT-977813. spr.
Enzyme and pathway databases
BRENDA	1.1.1.153. 279072.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. IPR006393. Sepiapterin_red. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH.
TIGRFAMs	TIGR01500. sepiapter_red. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SPRE_XENTR

Accession

Primary (citable) accession number: B0BML7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	February 26, 2008
Last modified:	June 16, 2009
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project