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B0BM36

- SDHB_XENTR

UniProt

B0BM36 - SDHB_XENTR

Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene

sdhb

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

    Catalytic activityi

    Succinate + a quinone = fumarate + a quinol.

    Cofactori

    Binds 1 2Fe-2S cluster.By similarity
    Binds 1 3Fe-4S cluster.By similarity
    Binds 1 4Fe-4S cluster.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi97 – 971Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi102 – 1021Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi105 – 1051Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi117 – 1171Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi190 – 1901Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi193 – 1931Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi196 – 1961Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi200 – 2001Iron-sulfur 3 (3Fe-4S)By similarity
    Binding sitei205 – 2051Ubiquinone; shared with dhsdBy similarity
    Metal bindingi247 – 2471Iron-sulfur 3 (3Fe-4S)By similarity
    Metal bindingi253 – 2531Iron-sulfur 3 (3Fe-4S)By similarity
    Metal bindingi257 – 2571Iron-sulfur 2 (4Fe-4S)By similarity

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB
    2. 3 iron, 4 sulfur cluster binding Source: UniProtKB
    3. 4 iron, 4 sulfur cluster binding Source: UniProtKB
    4. electron carrier activity Source: InterPro
    5. metal ion binding Source: UniProtKB-KW
    6. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
    7. ubiquinone binding Source: UniProtKB

    GO - Biological processi

    1. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_216811. Respiratory electron transport.
    UniPathwayiUPA00223; UER01006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC:1.3.5.1)
    Alternative name(s):
    Iron-sulfur subunit of complex II
    Short name:
    Ip
    Gene namesi
    Name:sdhb
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-970193. sdhb.

    Subcellular locationi

    Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB
    2. mitochondrial respiratory chain complex II Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2626MitochondrionBy similarityAdd
    BLAST
    Chaini27 – 284258Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialPRO_0000343803Add
    BLAST

    Proteomic databases

    PaxDbiB0BM36.

    Expressioni

    Gene expression databases

    BgeeiB0BM36.

    Interactioni

    Subunit structurei

    Component of complex II composed of four subunits: the flavoprotein (FP) sdha, iron-sulfur protein (IP) sdhb, and a cytochrome b composed of sdhc and sdhd.By similarity

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000029442.

    Structurei

    3D structure databases

    ProteinModelPortaliB0BM36.
    SMRiB0BM36. Positions 42-279.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini44 – 137942Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini180 – 210314Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
    Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0479.
    GeneTreeiENSGT00390000013558.
    HOGENOMiHOG000160590.
    HOVERGENiHBG005483.
    KOiK00235.
    OMAiQYEKIRP.
    OrthoDBiEOG7H4DTN.
    TreeFamiTF300754.

    Family and domain databases

    Gene3Di3.10.20.30. 1 hit.
    InterProiIPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR012675. Beta-grasp_dom.
    IPR009051. Helical_ferredxn.
    IPR004489. Succ_DH/fum_Rdtase_Fe-S.
    IPR025192. Succ_DH/fum_Rdtase_N.
    [Graphical view]
    PfamiPF13085. Fer2_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF46548. SSF46548. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsiTIGR00384. dhsB. 1 hit.
    PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B0BM36-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAVVFSLRR SGPVFRLPGV LQVCRGAQTA AAAAPASQAE ARIKKFAIYR    50
    WDPDKPGDKP RMQTYEVDLN ECGSMVLDAL IKIKNEMDPT LTFRRSCREG 100
    ICGSCAMNIN GGNTLACTVR IDTNLSKVSK IYPLPHMYVV KDLVPDLSNF 150
    YAQYKSIEPY LKKKDESQEG KEQYLQSIED RDKLDGLYEC ILCACCSTSC 200
    PSYWWNADKY LGPAVLMQAY RWMIDSRDDY TEERLAKLQD PFSLYRCHTI 250
    MNCTRTCPKG LNPGKAIAEI KKMMATYKER AASV 284
    Length:284
    Mass (Da):32,087
    Last modified:February 26, 2008 - v1
    Checksum:i88CCE71B1DCB3D6C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC158270 mRNA. Translation: AAI58271.1.
    RefSeqiNP_001120000.1. NM_001126528.1.
    UniGeneiStr.51669.

    Genome annotation databases

    EnsembliENSXETT00000029442; ENSXETP00000029442; ENSXETG00000013435.
    GeneIDi100144957.
    KEGGixtr:100144957.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC158270 mRNA. Translation: AAI58271.1 .
    RefSeqi NP_001120000.1. NM_001126528.1.
    UniGenei Str.51669.

    3D structure databases

    ProteinModelPortali B0BM36.
    SMRi B0BM36. Positions 42-279.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000029442.

    Proteomic databases

    PaxDbi B0BM36.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSXETT00000029442 ; ENSXETP00000029442 ; ENSXETG00000013435 .
    GeneIDi 100144957.
    KEGGi xtr:100144957.

    Organism-specific databases

    CTDi 6390.
    Xenbasei XB-GENE-970193. sdhb.

    Phylogenomic databases

    eggNOGi COG0479.
    GeneTreei ENSGT00390000013558.
    HOGENOMi HOG000160590.
    HOVERGENi HBG005483.
    KOi K00235.
    OMAi QYEKIRP.
    OrthoDBi EOG7H4DTN.
    TreeFami TF300754.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER01006 .
    Reactomei REACT_216811. Respiratory electron transport.

    Gene expression databases

    Bgeei B0BM36.

    Family and domain databases

    Gene3Di 3.10.20.30. 1 hit.
    InterProi IPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR012675. Beta-grasp_dom.
    IPR009051. Helical_ferredxn.
    IPR004489. Succ_DH/fum_Rdtase_Fe-S.
    IPR025192. Succ_DH/fum_Rdtase_N.
    [Graphical view ]
    Pfami PF13085. Fer2_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46548. SSF46548. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsi TIGR00384. dhsB. 1 hit.
    PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiSDHB_XENTR
    AccessioniPrimary (citable) accession number: B0BM36
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3