Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor

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B0BM36 (DHSB_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 43. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
EC=1.3.5.1

Alternative name(s):
Iron-sulfur subunit of complex II
Short name=Ip

Gene names

Name:

sdhb

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity.
Catalytic activity	Succinate + ubiquinone = fumarate + ubiquinol.
Cofactor	Binds 1 2Fe-2S cluster By similarity. Binds 1 3Fe-4S cluster By similarity. Binds 1 4Fe-4S cluster By similarity.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.
Subunit structure	Component of complex II composed of four subunits: the flavoprotein (FP) sdha, iron-sulfur protein (IP) sdhb, and a cytochrome b composed of sdhc and sdhd By similarity.
Subcellular location	Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity.
Sequence similarities	Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. Contains 1 2Fe-2S ferredoxin-type domain. Contains 1 4Fe-4S ferredoxin-type domain.

Ontologies

Keywords
Biological process	Electron transport Transport Tricarboxylic acid cycle
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide
Ligand	2Fe-2S 3Fe-4S 4Fe-4S Iron Iron-sulfur Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	mitochondrial respiratory chain complex II Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	2 iron, 2 sulfur cluster binding Inferred from sequence or structural similarity. Source: UniProtKB 3 iron, 4 sulfur cluster binding Inferred from sequence or structural similarity. Source: UniProtKB 4 iron, 4 sulfur cluster binding Inferred from sequence or structural similarity. Source: UniProtKB electron carrier activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW succinate dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: EC ubiquinone binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Transit peptide

1 – 26

Mitochondrion By similarity

Chain

27 – 284

258

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

PRO_0000343803

Regions

Domain

44 – 137

2Fe-2S ferredoxin-type

Domain

180 – 210

4Fe-4S ferredoxin-type

Sites

Metal binding

Iron-sulfur 1 (2Fe-2S) By similarity

Metal binding

102

Iron-sulfur 1 (2Fe-2S) By similarity

Metal binding

105

Iron-sulfur 1 (2Fe-2S) By similarity

Metal binding

117

Iron-sulfur 1 (2Fe-2S) By similarity

Metal binding

190

Iron-sulfur 2 (4Fe-4S) By similarity

Metal binding

193

Iron-sulfur 2 (4Fe-4S) By similarity

Metal binding

196

Iron-sulfur 2 (4Fe-4S) By similarity

Metal binding

200

Iron-sulfur 3 (3Fe-4S) By similarity

Metal binding

247

Iron-sulfur 3 (3Fe-4S) By similarity

Metal binding

253

Iron-sulfur 3 (3Fe-4S) By similarity

Metal binding

257

Iron-sulfur 2 (4Fe-4S) By similarity

Binding site

205

Ubiquinone; shared with dhsd By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

B0BM36 [UniParc].

Last modified February 26, 2008. Version 1.
Checksum: 88CCE71B1DCB3D6C
Show »

FASTA

284

32,087

        10         20         30         40         50         60 
MAAVVFSLRR SGPVFRLPGV LQVCRGAQTA AAAAPASQAE ARIKKFAIYR WDPDKPGDKP 

        70         80         90        100        110        120 
RMQTYEVDLN ECGSMVLDAL IKIKNEMDPT LTFRRSCREG ICGSCAMNIN GGNTLACTVR 

       130        140        150        160        170        180 
IDTNLSKVSK IYPLPHMYVV KDLVPDLSNF YAQYKSIEPY LKKKDESQEG KEQYLQSIED 

       190        200        210        220        230        240 
RDKLDGLYEC ILCACCSTSC PSYWWNADKY LGPAVLMQAY RWMIDSRDDY TEERLAKLQD 

       250        260        270        280 
PFSLYRCHTI MNCTRTCPKG LNPGKAIAEI KKMMATYKER AASV

« Hide

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC158270 mRNA. Translation: AAI58271.1.
RefSeq	NP_001120000.1. NM_001126528.1.
UniGene	Str.51669.
3D structure databases
ProteinModelPortal	B0BM36.
SMR	B0BM36. Positions 42-279.
ModBase	Search...
Protein-protein interaction databases
STRING	8364.ENSXETP00000029442.
Proteomic databases
PaxDb	B0BM36.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSXETT00000029442; ENSXETP00000029442; ENSXETG00000013435.
GeneID	100144957.
KEGG	xtr:100144957.
Organism-specific databases
CTD	6390.
Xenbase	XB-GENE-970193. sdhb.
Phylogenomic databases
eggNOG	COG0479.
GeneTree	ENSGT00390000013558.
HOGENOM	HOG000160590.
HOVERGEN	HBG005483.
KO	K00235.
OMA	LIVDMEP.
OrthoDB	EOG4T4CW4.
Enzyme and pathway databases
UniPathway	UPA00223; UER01006.
Gene expression databases
Bgee	B0BM36.
Family and domain databases
Gene3D	1.10.1060.10. 1 hit. 3.10.20.30. 1 hit.
InterPro	IPR001041. 2Fe-2S_ferredoxin-type. IPR006058. 2Fe2S_fd_BS. IPR017896. 4Fe4S_Fe-S-bd. IPR017900. 4Fe4S_Fe_S_CS. IPR012675. Beta-grasp_dom. IPR012285. Fum_reductase_C. IPR009051. Helical_ferredxn. IPR004489. Succ_DH/fum_Rdtase_Fe-S. IPR025192. Succ_DH/fum_Rdtase_N. [Graphical view]
Pfam	PF13085. Fer2_3. 1 hit. [Graphical view]
SUPFAM	SSF54292. Ferredoxin. 1 hit. SSF46548. Helical_ferredxn. 1 hit.
TIGRFAMs	TIGR00384. dhsB. 1 hit.
PROSITE	PS00197. 2FE2S_FER_1. 1 hit. PS51085. 2FE2S_FER_2. 1 hit. PS00198. 4FE4S_FER_1. 1 hit. PS51379. 4FE4S_FER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHSB_XENTR

Accession

Primary (citable) accession number: B0BM36

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
Last sequence update:	February 26, 2008
Last modified:	April 3, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents