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B0BM36 (SDHB_XENTR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

EC=1.3.5.1
Alternative name(s):
Iron-sulfur subunit of complex II
Short name=Ip
Gene names
Name:sdhb
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Protein attributes

Sequence length284 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity.

Catalytic activity

Succinate + a quinone = fumarate + a quinol.

Cofactor

Binds 1 2Fe-2S cluster By similarity.

Binds 1 3Fe-4S cluster By similarity.

Binds 1 4Fe-4S cluster By similarity.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.

Subunit structure

Component of complex II composed of four subunits: the flavoprotein (FP) sdha, iron-sulfur protein (IP) sdhb, and a cytochrome b composed of sdhc and sdhd By similarity.

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity.

Sequence similarities

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 1 4Fe-4S ferredoxin-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2626Mitochondrion By similarity
Chain27 – 284258Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
PRO_0000343803

Regions

Domain44 – 137942Fe-2S ferredoxin-type
Domain180 – 210314Fe-4S ferredoxin-type

Sites

Metal binding971Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1021Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1051Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1171Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1901Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1931Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1961Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding2001Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2471Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2531Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2571Iron-sulfur 2 (4Fe-4S) By similarity
Binding site2051Ubiquinone; shared with dhsd By similarity

Sequences

Sequence LengthMass (Da)Tools
B0BM36 [UniParc].

Last modified February 26, 2008. Version 1.
Checksum: 88CCE71B1DCB3D6C

FASTA28432,087
        10         20         30         40         50         60 
MAAVVFSLRR SGPVFRLPGV LQVCRGAQTA AAAAPASQAE ARIKKFAIYR WDPDKPGDKP 

        70         80         90        100        110        120 
RMQTYEVDLN ECGSMVLDAL IKIKNEMDPT LTFRRSCREG ICGSCAMNIN GGNTLACTVR 

       130        140        150        160        170        180 
IDTNLSKVSK IYPLPHMYVV KDLVPDLSNF YAQYKSIEPY LKKKDESQEG KEQYLQSIED 

       190        200        210        220        230        240 
RDKLDGLYEC ILCACCSTSC PSYWWNADKY LGPAVLMQAY RWMIDSRDDY TEERLAKLQD 

       250        260        270        280 
PFSLYRCHTI MNCTRTCPKG LNPGKAIAEI KKMMATYKER AASV 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC158270 mRNA. Translation: AAI58271.1.
RefSeqNP_001120000.1. NM_001126528.1.
UniGeneStr.51669.

3D structure databases

ProteinModelPortalB0BM36.
SMRB0BM36. Positions 42-279.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING8364.ENSXETP00000029442.

Proteomic databases

PaxDbB0BM36.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSXETT00000029442; ENSXETP00000029442; ENSXETG00000013435.
GeneID100144957.
KEGGxtr:100144957.

Organism-specific databases

CTD6390.
XenbaseXB-GENE-970193. sdhb.

Phylogenomic databases

eggNOGCOG0479.
GeneTreeENSGT00390000013558.
HOGENOMHOG000160590.
HOVERGENHBG005483.
KOK00235.
OMAQAGNCIL.
OrthoDBEOG7H4DTN.
TreeFamTF300754.

Enzyme and pathway databases

UniPathwayUPA00223; UER01006.

Gene expression databases

BgeeB0BM36.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
InterProIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsTIGR00384. dhsB. 1 hit.
PROSITEPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSDHB_XENTR
AccessionPrimary (citable) accession number: B0BM36
Entry history
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: February 26, 2008
Last modified: April 16, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways