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B0BC67

- DAPF_CHLTB

UniProt

B0BC67 - DAPF_CHLTB

Protein

Diaminopimelate epimerase

Gene

dapF

Organism
Chlamydia trachomatis serovar L2b (strain UCH-1/proctitis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.UniRule annotation

    Catalytic activityi

    LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei20 – 201SubstrateUniRule annotation
    Binding sitei45 – 451SubstrateUniRule annotation
    Binding sitei63 – 631SubstrateUniRule annotation
    Active sitei72 – 721Proton donor/acceptorUniRule annotation
    Sitei147 – 1471Important for catalytic activityUniRule annotation
    Binding sitei179 – 1791SubstrateUniRule annotation
    Sitei197 – 1971Important for catalytic activityUniRule annotation
    Active sitei207 – 2071Proton donor/acceptorUniRule annotation

    GO - Molecular functioni

    1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Lysine biosynthesis

    Enzyme and pathway databases

    BioCyciCTRA471473:GHJK-719-MONOMER.
    UniPathwayiUPA00034; UER00025.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diaminopimelate epimeraseUniRule annotation (EC:5.1.1.7UniRule annotation)
    Short name:
    DAP epimeraseUniRule annotation
    Gene namesi
    Name:dapFUniRule annotation
    Ordered Locus Names:CTLon_0685
    OrganismiChlamydia trachomatis serovar L2b (strain UCH-1/proctitis)
    Taxonomic identifieri471473 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000794: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 275275Diaminopimelate epimerasePRO_1000099227Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi72 ↔ 207

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi471473.CTLon_0685.

    Structurei

    3D structure databases

    ProteinModelPortaliB0BC67.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni72 – 743Substrate bindingUniRule annotation
    Regioni197 – 1982Substrate bindingUniRule annotation
    Regioni208 – 2092Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the diaminopimelate epimerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0253.
    HOGENOMiHOG000220466.
    KOiK01778.
    OMAiNGLRCVI.
    OrthoDBiEOG6ND0M5.

    Family and domain databases

    HAMAPiMF_00197. DAP_epimerase.
    InterProiIPR018510. DAP_epimerase_AS.
    IPR001653. DAP_epimerase_DapF.
    [Graphical view]
    PANTHERiPTHR31689. PTHR31689. 1 hit.
    PfamiPF01678. DAP_epimerase. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00652. DapF. 1 hit.
    PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0BC67-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGFSSLLTTC RYLLYSGAGN SFILGESMPS LEDVLFLCQE EMVDGFLCVE    50
    SSEIADAKLT VFNSDGSIAS MCGNGLRCAM AHVAQCFGLE DVSIETERGV 100
    YQGKFFSMNR VLVDMTLPDW KKAERKLTHV LPGMPEQVFF IDTGVPHVVV 150
    FVSDLSKVPV QEWGSFLRYH EDFAPEGVNV DFVQRKKDDL LLVYTYERGC 200
    ERETLSCGTG MLASALVAAD IFSLGQDFSI AVCSRSRNLI KIFSEKGKVF 250
    LEGPVSLLNR SENFGWLEPK SRRFG 275
    Length:275
    Mass (Da):30,576
    Last modified:February 26, 2008 - v1
    Checksum:i38882BBA95327335
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM884177 Genomic DNA. Translation: CAP07082.1.
    RefSeqiYP_001653773.1. NC_010280.2.

    Genome annotation databases

    EnsemblBacteriaiCAP07082; CAP07082; CTLon_0685.
    GeneIDi5858994.
    KEGGictl:CTLon_0685.
    PATRICi20383033. VBIChlTra68089_0742.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM884177 Genomic DNA. Translation: CAP07082.1 .
    RefSeqi YP_001653773.1. NC_010280.2.

    3D structure databases

    ProteinModelPortali B0BC67.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 471473.CTLon_0685.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAP07082 ; CAP07082 ; CTLon_0685 .
    GeneIDi 5858994.
    KEGGi ctl:CTLon_0685.
    PATRICi 20383033. VBIChlTra68089_0742.

    Phylogenomic databases

    eggNOGi COG0253.
    HOGENOMi HOG000220466.
    KOi K01778.
    OMAi NGLRCVI.
    OrthoDBi EOG6ND0M5.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00025 .
    BioCyci CTRA471473:GHJK-719-MONOMER.

    Family and domain databases

    HAMAPi MF_00197. DAP_epimerase.
    InterProi IPR018510. DAP_epimerase_AS.
    IPR001653. DAP_epimerase_DapF.
    [Graphical view ]
    PANTHERi PTHR31689. PTHR31689. 1 hit.
    Pfami PF01678. DAP_epimerase. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00652. DapF. 1 hit.
    PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: UCH-1/proctitis.

    Entry informationi

    Entry nameiDAPF_CHLTB
    AccessioniPrimary (citable) accession number: B0BC67
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3