B0BC12 (G6PI_CHLTB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	CTLon_0630

Organism

Chlamydia trachomatis serovar L2b (strain UCH-1/proctitis) [Complete proteome] [HAMAP]

Taxonomic identifier

471473 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	525 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 525	525	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_1000125706
Sites
	Active site	378	1	By similarity
	Active site	493	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B0BC12 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: BF49762A614C6ADE	FASTA	525	57,700
	10 20 30 40 50 60 MMGKGFLDCE SLVALQEMAL HPIDLTASGC LSEERIQKNS LSVEGFTYSY ATERVDDRCL 70 80 90 100 110 120 EALQGLTEER ELIKQMECMQ QGAIMNRIEG FQSESRPVLH TATRAWVRDQ DLHEEAAAIA 130 140 150 160 170 180 RHSKEEALRL AEFLYIARAK FSTLVQIGIG GSELGPKAMY FAMQGSCPSD KRIFFVSNID 190 200 210 220 230 240 PDNAAEVLRE IDLEQTLVVV VSKSGTTLEP AANEELFRQA YQNKGLSIAE HFVAVTSQGS 250 260 270 280 290 300 PMDDKSRYLE VFHLWDSIGG RFSATSMVGG VVLGFAFGYE AFIEFLQGAA AIDAHALTPK 310 320 330 340 350 360 MRENLPLLSA MLGVWNRNLL GYPTTAVIPY STGLKYFTAH LQQCGMESNG KSISREGKEI 370 380 390 400 410 420 SFRTSPIIWG DVGTNCQHSF FQSLHQGTDI VPVEFIGFLH NQRGLDCVLS GSSSSQKLFA 430 440 450 460 470 480 NLVAQSLALA QGRDNANPNK RFKGNSPSSI LVAQQLSPRI AGSLLAFYEH KFAFQGFCWG 490 500 510 520 INSFDQEGVS LGKELATQII GIMSGNAPVE FPEARGVLRL FNVLT

References

[1]

"Chlamydia trachomatis: genome sequence analysis of lymphogranuloma venereum isolates." Thomson N.R., Holden M.T.G., Carder C., Lennard N., Lockey S.J., Marsh P., Skipp P., O'Connor C.D., Goodhead I., Norbertzcak H., Harris B., Ormond D., Rance R., Quail M.A., Parkhill J., Stephens R.S., Clarke I.N. Genome Res. 18:161-171(2008) [PubMed: 18032721] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: UCH-1/proctitis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM884177 Genomic DNA. Translation: CAP07027.1.
RefSeq	YP_001653718.1. NC_010280.2.
3D structure databases
ProteinModelPortal	B0BC12.
ModBase	Search...
Protein-protein interaction databases
STRING	B0BC12.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5859578.
GenomeReviews	Gene locus CTLon_0630 in contig AM884177_GR.
KEGG	ctl:CTLon_0630.
PATRIC	20382913. VBIChlTra68089_0684.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG352954.
OMA	NSLPAWT.
ProtClustDB	PRK14095.
Enzyme and pathway databases
BioCyc	CTRA471473:CTLON_0630-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
Gene3D	G3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_CHLTB

Accession

Primary (citable) accession number: B0BC12

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 26, 2008
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program