B0BC00 (AROA_CHLTB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	CTLon_0618

Organism

Chlamydia trachomatis serovar L2b (strain UCH-1/proctitis) [Complete proteome] [HAMAP]

Taxonomic identifier

471473 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	440 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 440	440	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_1000099684

Sequences

	Sequence		Length	Mass (Da)
	B0BC00 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: A4FEA6A3FDB5F5D3	FASTA	440	47,770
	10 20 30 40 50 60 MVSSNQALLI SPSIPYGEIA VPPSKSHSLR AILFASLSKG TSIIENCLFS PDSQTMLTAC 70 80 90 100 110 120 EKMGAHVRRI GDSLHIQGNP DPHHCHPPYF HMGNSGIALR FLTALSTLSP TPTLITGSHT 130 140 150 160 170 180 LKRRPIAPLL SSLKQLGAHI RQKTSSSIPF TIHGPLSPGH VTISGQDSQY ASALAITAAL 190 200 210 220 230 240 APYPLSFSIE NLKERPWFDL TLDWLHSLNI SFLRDQDSLT FPGGQSLESF SYSVPGDYSS 250 260 270 280 290 300 AAFLASFGLL SSSSKPTILR NLPSQDSQGD KLLFSLLKQL GAHILIEKHH IEMHPSSFSG 310 320 330 340 350 360 GEIDMDPFID ALPILAVLCC FAKNPSRLYN ALGAKDKESN RIEAIAHELQ KMGGSVHPTR 370 380 390 400 410 420 DGLYIEPSRL HGAVVDSHND HRIAMALAVA GVHASSGQTL LCNTQCINKS FPHFVIAAQT 430 440 LHANVRHYQA DFPLRSSFCR

References

[1]

"Chlamydia trachomatis: genome sequence analysis of lymphogranuloma venereum isolates." Thomson N.R., Holden M.T.G., Carder C., Lennard N., Lockey S.J., Marsh P., Skipp P., O'Connor C.D., Goodhead I., Norbertzcak H., Harris B., Ormond D., Rance R., Quail M.A., Parkhill J., Stephens R.S., Clarke I.N. Genome Res. 18:161-171(2008) [PubMed: 18032721] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: UCH-1/proctitis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM884177 Genomic DNA. Translation: CAP07015.1.
RefSeq	YP_001653707.1. NC_010280.2.
3D structure databases
ProteinModelPortal	B0BC00.
ModBase	Search...
Protein-protein interaction databases
STRING	B0BC00.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5859035.
GenomeReviews	Gene locus CTLon_0618 in contig AM884177_GR.
KEGG	ctl:CTLon_0618.
PATRIC	20382887. VBIChlTra68089_0671.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG646626.
OMA	FADHRIA.
ProtClustDB	PRK02427.
Enzyme and pathway databases
BioCyc	CTRA471473:CTLON_0618-MONOMER.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_CHLTB

Accession

Primary (citable) accession number: B0BC00

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	February 26, 2008
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program