B0BBQ6 (B0BBQ6_CHLTB) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Chromosomal replication initiator protein DnaA 2 HAMAP MF_00377

Gene names

Name:	dnaA2 HAMAP MF_00377 EMBL CAP06921.1
Ordered Locus Names:	CTLon_0523

Organism

Chlamydia trachomatis serovar L2b (strain UCH-1/proctitis) [Complete proteome] [HAMAP] EMBL CAP06921.1

Taxonomic identifier

471473 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	455 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP MF_00377
Subcellular location	Cytoplasm By similarity HAMAP MF_00377.
Sequence similarities	Belongs to the DnaA family. HAMAP MF_00377

Ontologies

Keywords
Biological process	DNA replication HAMAP MF_00377
Cellular component	Cytoplasm HAMAP MF_00377
Ligand	ATP-binding HAMAP MF_00377 DNA-binding HAMAP MF_00377 Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA-dependent DNA replication initiation Inferred from electronic annotation. Source: HAMAP regulation of DNA replication Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA replication origin binding Inferred from electronic annotation. Source: HAMAP nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	154 – 161	8	ATP By similarity HAMAP MF_00377

Sequences

	Sequence		Length	Mass (Da)
	B0BBQ6 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: 99FBD4D1354E91F5	FASTA	455	51,348
	10 20 30 40 50 60 MLTCNDCSTW EQFVNYIKTR CSKTAFENWI APIQVLEESS EKIRLEIPNI FVQSYLLDNY 70 80 90 100 110 120 KKDLCSFVPL DAEGNPALEF VVAEIKRSSP LVTPSIAKPA TEVSEENKDF QLKLNGAYRF 130 140 150 160 170 180 DNFIEGPSNQ FVKSAALGIA ARPGRSYNPL FIHGGVGLGK THLLHAVGHY VREHHKNLRI 190 200 210 220 230 240 HCITTEAFIN DLVHHLRVKS IDKMKNFYRS LDLLLVDDIQ FLQNRQNFEE EFCNTFETLI 250 260 270 280 290 300 HLSKQIVVTS DKPPGQLKLS ERIIARMEWG LVAHVGVPDL ETRVAILQHK AEQKGLNIPN 310 320 330 340 350 360 EMAFYIADHV YGNVRQLEGA INKLTAYCLL FNKPLTETTV RDTLKELFRA PSKQKVSVES 370 380 390 400 410 420 ILKSVATVFQ VKIQDLKGSS RAKNVPLARQ VAMYLAKTLI TDSLVAIGAA FGKTHSTVLY 430 440 450 ACKTIEQKIE KDALLKNQIS LCKNNIAIDS PQHFV

References

[1]

"Chlamydia trachomatis: genome sequence analysis of lymphogranuloma venereum isolates." Thomson N.R., Holden M.T.G., Carder C., Lennard N., Lockey S.J., Marsh P., Skipp P., O'Connor C.D., Goodhead I., Norbertzcak H., Harris B., Ormond D., Rance R., Quail M.A., Parkhill J., Stephens R.S., Clarke I.N. Genome Res. 18:161-171(2008) [PubMed: 18032721] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM884177 Genomic DNA. Translation: CAP06921.1.
RefSeq	YP_001653616.1. NC_010280.2.
3D structure databases
ProteinModelPortal	B0BBQ6.
ModBase	Search...
Protein-protein interaction databases
STRING	B0BBQ6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5859082.
GenomeReviews	Gene locus CTLon_0523 in contig AM884177_GR.
KEGG	ctl:CTLon_0523.
PATRIC	20382675. VBIChlTra68089_0569.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG695666.
OMA	CHTLNAL.
ProtClustDB	PRK00149.
Family and domain databases
HAMAP	MF_00377. DnaA_bact. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013159. DnaA_C. IPR013317. DnaA_Hda. IPR010921. Trp_repressor/repl_initiator. [Graphical view]
Gene3D	G3DSA:1.10.1750.10. DnaA_C. 1 hit.
KO	K02313.
Pfam	PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. [Graphical view]
PRINTS	PR00051. DNAA.
SMART	SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. [Graphical view]
SUPFAM	SSF48295. Trp_repress_rep. 1 hit.
TIGRFAMs	TIGR00362. DnaA. 1 hit.
PROSITE	PS01008. DNAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B0BBQ6_CHLTB

Accession

Primary (citable) accession number: B0BBQ6

Entry history

Integrated into UniProtKB/TrEMBL:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)