B0BBJ8 (SURE_CHLTB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5'-nucleotidase surE
EC=3.1.3.5

Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolase

Gene names

Name:	surE
Ordered Locus Names:	CTLon_0465

Organism

Chlamydia trachomatis serovar L2b (strain UCH-1/proctitis) [Complete proteome] [HAMAP]

Taxonomic identifier

471473 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	283 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity. HAMAP MF_00060
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060
Cofactor	Binds 1 divalent metal cation per subunit By similarity.
Subcellular location	Cytoplasm Potential HAMAP MF_00060.
Sequence similarities	Belongs to the surE nucleotidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 283	283	5'-nucleotidase surE HAMAP MF_00060		PRO_1000091990
Sites
	Metal binding	14	1	Divalent metal cation By similarity
	Metal binding	15	1	Divalent metal cation By similarity
	Metal binding	47	1	Divalent metal cation By similarity
	Metal binding	105	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	B0BBJ8 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: D5AA6EBF69AF3DDA	FASTA	283	31,516
	10 20 30 40 50 60 MTETRRLRIL ITNDDGIKAK GISLLISLLR EADFADLYVV APLEEQSGRS MAFSLVEPTA 70 80 90 100 110 120 LEPFDYPQRV QEAWAVTGTP VDCVKLAIGE LFKENALDLI LSGINNGKNS GRCLYYSATV 130 140 150 160 170 180 GAIREANLHG IPAIALSQSE NIAFFQEAHM ASLIRSLCEF TVAYKHTDPL GLNVNFPASA 190 200 210 220 230 240 DDSPWKGIRF TLSGNEFLFG IPRLVRTEGN RRYYTLYDMR DKVSEEFSEE YLALANNYIS 250 260 270 280 AAPLVSKNTP RATLSEEELA FLKDSFEQSV LWKASLNLEE DLA

References

[1]

"Chlamydia trachomatis: genome sequence analysis of lymphogranuloma venereum isolates." Thomson N.R., Holden M.T.G., Carder C., Lennard N., Lockey S.J., Marsh P., Skipp P., O'Connor C.D., Goodhead I., Norbertzcak H., Harris B., Ormond D., Rance R., Quail M.A., Parkhill J., Stephens R.S., Clarke I.N. Genome Res. 18:161-171(2008) [PubMed: 18032721] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: UCH-1/proctitis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM884177 Genomic DNA. Translation: CAP06863.1.
RefSeq	YP_001653558.1. NC_010280.2.
3D structure databases
ProteinModelPortal	B0BBJ8.
ModBase	Search...
Protein-protein interaction databases
STRING	B0BBJ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5859134.
GenomeReviews	Gene locus CTLon_0465 in contig AM884177_GR.
KEGG	ctl:CTLon_0465.
PATRIC	20382547. VBIChlTra68089_0507.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG600532.
OMA	HAPALIR.
ProtClustDB	PRK00346.
Enzyme and pathway databases
BioCyc	CTRA471473:CTLON_0465-MONOMER.
Family and domain databases
HAMAP	MF_00060. SurE. [Tree]
InterPro	IPR002828. SurE-like_Pase/nucleotidase. [Graphical view]
Gene3D	G3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
KO	K03787.
Pfam	PF01975. SurE. 1 hit. [Graphical view]
SUPFAM	SSF64167. SurE-like_Pase/nucleotidase. 1 hit.
TIGRFAMs	TIGR00087. SurE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SURE_CHLTB

Accession

Primary (citable) accession number: B0BBJ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	February 26, 2008
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program