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Protein

Translation initiation factor IF-2

Gene

infB

Organism
Chlamydia trachomatis serovar L2b (strain UCH-1/proctitis)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi410 – 417GTPUniRule annotation8
Nucleotide bindingi456 – 460GTPUniRule annotation5
Nucleotide bindingi510 – 513GTPUniRule annotation4

GO - Molecular functioni

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-2UniRule annotation
Gene namesi
Name:infBUniRule annotation
Ordered Locus Names:CTLon_0347
OrganismiChlamydia trachomatis serovar L2b (strain UCH-1/proctitis)
Taxonomic identifieri471473 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000937721 – 896Translation initiation factor IF-2Add BLAST896

Structurei

3D structure databases

ProteinModelPortaliB0BB83.
SMRiB0BB83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini401 – 570tr-type GAdd BLAST170

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni410 – 417G1By similarity8
Regioni435 – 439G2By similarity5
Regioni456 – 459G3By similarity4
Regioni510 – 513G4By similarity4
Regioni546 – 548G5By similarity3

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076906.
KOiK02519.
OMAiDNRTGGY.

Family and domain databases

Gene3Di3.40.50.10050. 1 hit.
HAMAPiMF_00100_B. IF_2_B. 1 hit.
InterProiView protein in InterPro
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR036925. TIF_IF2_dom3_sf.
IPR009000. Transl_B-barrel_sf.
PANTHERiPTHR43381. PTHR43381. 1 hit.
PfamiView protein in Pfam
PF00009. GTP_EFTU. 1 hit.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 1 hit.
SUPFAMiSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51722. G_TR_2. 1 hit.
PS01176. IF2. 1 hit.

Sequencei

Sequence statusi: Complete.

B0BB83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKAKLTKNL KLKIKNAQLT KAAGLDKLKQ KLAQAGSSDT KNSPASKAQT
60 70 80 90 100
KEKSSKKTAG TPAPAPEVDL GATESTARRI RAKDRSSFAA EPTVTTALPG
110 120 130 140 150
DASHLTLDAI PAIKAPEITS VTQKEQTLRE CTDTSSVQQE EKKESSEETS
160 170 180 190 200
PETPERIEET PIIRTRTEPK SVVSIKPKFG PTGKHINHLL AKTFKAPAKE
210 220 230 240 250
TKAASTEETT QQQPRQNDAA SHNNKQQPSG TSSRPASSAP SYRRESTSNN
260 270 280 290 300
NNNAKRGSER DRSKRSDESV KAFTGRDRYG LNEGSSEEDK WRKKRVHKTK
310 320 330 340 350
KQAEEHVVQC PAHIKIALPI TVKDLAAEMK LKASELIQKL FIHGMTYVVN
360 370 380 390 400
DVLDSQTVVE YIGLEFGCTI EIDSSAKEKL CLVENTVRDE VNATDPEKLI
410 420 430 440 450
IRSPIVAFMG HVDHGKTTII DALRQSNMAA SEAGAITQHT GAFKCTTPVG
460 470 480 490 500
EITVLDTPGH EAFSAMRARG AEVCDIVVLV VAGDEGIKEQ TIEAIEHAKG
510 520 530 540 550
ANITIVVAIN KCDKPNFNVE TVYRQLAELD LLPEAWGGSI ATINTSAKTG
560 570 580 590 600
EGLQDLLEML ALQAEVLELK ADPSARARGL VIESELHKGL GAVATVLVQN
610 620 630 640 650
GTLHLGEALV FNDCYGKVKT MHDEHNQLLQ SATPSTPVLI TGLSAIPKAG
660 670 680 690 700
DPFIVVKNEK VAKEIISARL AGQQRSAALQ KKRPNFDAVL QNKKTLKLII
710 720 730 740 750
KADVQGSIEA LAHSILNIRS EKVDVEILSS GVGDISESDI RLASASKATV
760 770 780 790 800
IGFHTSVESH AEPLIKNLNV KVCLFDIIYH AVDAIKEIMT GLLDPIAEEK
810 820 830 840 850
NLGAAEIKAT FKSSQLGTIY GCLVTEGTVV RNQKIRIIRD KEVLWKGSLS
860 870 880 890
SLKRLKEDVK EVKKGMECGI LLDNYQQAQV GDILQCYEVI YHPQTL
Length:896
Mass (Da):97,378
Last modified:February 26, 2008 - v1
Checksum:i345BA0E5ED81170D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM884177 Genomic DNA. Translation: CAP06745.1.
RefSeqiWP_009873552.1. NC_010280.2.

Genome annotation databases

EnsemblBacteriaiCAP06745; CAP06745; CTLon_0347.
KEGGictl:CTLon_0347.

Similar proteinsi

Entry informationi

Entry nameiIF2_CHLTB
AccessioniPrimary (citable) accession number: B0BB83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 26, 2008
Last modified: November 22, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families