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B0BB83 (IF2_CHLTB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Translation initiation factor IF-2
Gene names
Name:infB
Ordered Locus Names:CTLon_0347
OrganismChlamydia trachomatis serovar L2b (strain UCH-1/proctitis) [Complete proteome] [HAMAP]
Taxonomic identifier471473 [NCBI]
Taxonomic lineageBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia

Protein attributes

Sequence length896 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity. HAMAP-Rule MF_00100

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00100.

Sequence similarities

Belongs to the IF-2 family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Molecular functionInitiation factor
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTPase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

translation initiation factor activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 896896Translation initiation factor IF-2 HAMAP-Rule MF_00100
PRO_1000093772

Regions

Nucleotide binding410 – 4178GTP By similarity
Nucleotide binding456 – 4605GTP By similarity
Nucleotide binding510 – 5134GTP By similarity
Region404 – 552149G-domain HAMAP-Rule MF_00100

Sequences

Sequence LengthMass (Da)Tools
B0BB83 [UniParc].

Last modified February 26, 2008. Version 1.
Checksum: 345BA0E5ED81170D

FASTA89697,378
        10         20         30         40         50         60 
MEKAKLTKNL KLKIKNAQLT KAAGLDKLKQ KLAQAGSSDT KNSPASKAQT KEKSSKKTAG 

        70         80         90        100        110        120 
TPAPAPEVDL GATESTARRI RAKDRSSFAA EPTVTTALPG DASHLTLDAI PAIKAPEITS 

       130        140        150        160        170        180 
VTQKEQTLRE CTDTSSVQQE EKKESSEETS PETPERIEET PIIRTRTEPK SVVSIKPKFG 

       190        200        210        220        230        240 
PTGKHINHLL AKTFKAPAKE TKAASTEETT QQQPRQNDAA SHNNKQQPSG TSSRPASSAP 

       250        260        270        280        290        300 
SYRRESTSNN NNNAKRGSER DRSKRSDESV KAFTGRDRYG LNEGSSEEDK WRKKRVHKTK 

       310        320        330        340        350        360 
KQAEEHVVQC PAHIKIALPI TVKDLAAEMK LKASELIQKL FIHGMTYVVN DVLDSQTVVE 

       370        380        390        400        410        420 
YIGLEFGCTI EIDSSAKEKL CLVENTVRDE VNATDPEKLI IRSPIVAFMG HVDHGKTTII 

       430        440        450        460        470        480 
DALRQSNMAA SEAGAITQHT GAFKCTTPVG EITVLDTPGH EAFSAMRARG AEVCDIVVLV 

       490        500        510        520        530        540 
VAGDEGIKEQ TIEAIEHAKG ANITIVVAIN KCDKPNFNVE TVYRQLAELD LLPEAWGGSI 

       550        560        570        580        590        600 
ATINTSAKTG EGLQDLLEML ALQAEVLELK ADPSARARGL VIESELHKGL GAVATVLVQN 

       610        620        630        640        650        660 
GTLHLGEALV FNDCYGKVKT MHDEHNQLLQ SATPSTPVLI TGLSAIPKAG DPFIVVKNEK 

       670        680        690        700        710        720 
VAKEIISARL AGQQRSAALQ KKRPNFDAVL QNKKTLKLII KADVQGSIEA LAHSILNIRS 

       730        740        750        760        770        780 
EKVDVEILSS GVGDISESDI RLASASKATV IGFHTSVESH AEPLIKNLNV KVCLFDIIYH 

       790        800        810        820        830        840 
AVDAIKEIMT GLLDPIAEEK NLGAAEIKAT FKSSQLGTIY GCLVTEGTVV RNQKIRIIRD 

       850        860        870        880        890 
KEVLWKGSLS SLKRLKEDVK EVKKGMECGI LLDNYQQAQV GDILQCYEVI YHPQTL 

« Hide

References

[1]"Chlamydia trachomatis: genome sequence analysis of lymphogranuloma venereum isolates."
Thomson N.R., Holden M.T.G., Carder C., Lennard N., Lockey S.J., Marsh P., Skipp P., O'Connor C.D., Goodhead I., Norbertzcak H., Harris B., Ormond D., Rance R., Quail M.A., Parkhill J., Stephens R.S., Clarke I.N.
Genome Res. 18:161-171(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: UCH-1/proctitis.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM884177 Genomic DNA. Translation: CAP06745.1.
RefSeqYP_001653447.1. NC_010280.2.

3D structure databases

ProteinModelPortalB0BB83.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING471473.CTLon_0347.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAP06745; CAP06745; CTLon_0347.
GeneID5858942.
KEGGctl:CTLon_0347.
PATRIC20382279. VBIChlTra68089_0379.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0532.
HOGENOMHOG000076906.
KOK02519.
OMAVTVKVIH.
OrthoDBEOG67HJSV.
ProtClustDBPRK05306.

Enzyme and pathway databases

BioCycCTRA471473:GHJK-368-MONOMER.

Family and domain databases

Gene3D3.40.50.10050. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00100_B. IF_2_B.
InterProIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR009000. Transl_B-barrel.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PANTHERPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 1 hit.
[Graphical view]
SUPFAMSSF50447. SSF50447. 2 hits.
SSF52156. SSF52156. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS01176. IF2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIF2_CHLTB
AccessionPrimary (citable) accession number: B0BB83
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 26, 2008
Last modified: April 16, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Translation initiation factors

List of translation initiation factor entries