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B0BB83

- IF2_CHLTB

UniProt

B0BB83 - IF2_CHLTB

Protein

Translation initiation factor IF-2

Gene

infB

Organism
Chlamydia trachomatis serovar L2b (strain UCH-1/proctitis)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi410 – 4178GTPUniRule annotation
    Nucleotide bindingi456 – 4605GTPUniRule annotation
    Nucleotide bindingi510 – 5134GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: UniProtKB-HAMAP
    2. GTP binding Source: UniProtKB-KW
    3. translation initiation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Initiation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCTRA471473:GHJK-368-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Translation initiation factor IF-2UniRule annotation
    Gene namesi
    Name:infBUniRule annotation
    Ordered Locus Names:CTLon_0347
    OrganismiChlamydia trachomatis serovar L2b (strain UCH-1/proctitis)
    Taxonomic identifieri471473 [NCBI]
    Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
    ProteomesiUP000000794: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 896896Translation initiation factor IF-2PRO_1000093772Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi471473.CTLon_0347.

    Structurei

    3D structure databases

    ProteinModelPortaliB0BB83.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini401 – 570170tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni410 – 4178G1By similarity
    Regioni435 – 4395G2By similarity
    Regioni456 – 4594G3By similarity
    Regioni510 – 5134G4By similarity
    Regioni546 – 5483G5By similarity

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0532.
    HOGENOMiHOG000076906.
    KOiK02519.
    OMAiMTNKLRI.
    OrthoDBiEOG67HJSV.

    Family and domain databases

    Gene3Di3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00100_B. IF_2_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PANTHERiPTHR23115:SF41. PTHR23115:SF41. 1 hit.
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0BB83-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKAKLTKNL KLKIKNAQLT KAAGLDKLKQ KLAQAGSSDT KNSPASKAQT    50
    KEKSSKKTAG TPAPAPEVDL GATESTARRI RAKDRSSFAA EPTVTTALPG 100
    DASHLTLDAI PAIKAPEITS VTQKEQTLRE CTDTSSVQQE EKKESSEETS 150
    PETPERIEET PIIRTRTEPK SVVSIKPKFG PTGKHINHLL AKTFKAPAKE 200
    TKAASTEETT QQQPRQNDAA SHNNKQQPSG TSSRPASSAP SYRRESTSNN 250
    NNNAKRGSER DRSKRSDESV KAFTGRDRYG LNEGSSEEDK WRKKRVHKTK 300
    KQAEEHVVQC PAHIKIALPI TVKDLAAEMK LKASELIQKL FIHGMTYVVN 350
    DVLDSQTVVE YIGLEFGCTI EIDSSAKEKL CLVENTVRDE VNATDPEKLI 400
    IRSPIVAFMG HVDHGKTTII DALRQSNMAA SEAGAITQHT GAFKCTTPVG 450
    EITVLDTPGH EAFSAMRARG AEVCDIVVLV VAGDEGIKEQ TIEAIEHAKG 500
    ANITIVVAIN KCDKPNFNVE TVYRQLAELD LLPEAWGGSI ATINTSAKTG 550
    EGLQDLLEML ALQAEVLELK ADPSARARGL VIESELHKGL GAVATVLVQN 600
    GTLHLGEALV FNDCYGKVKT MHDEHNQLLQ SATPSTPVLI TGLSAIPKAG 650
    DPFIVVKNEK VAKEIISARL AGQQRSAALQ KKRPNFDAVL QNKKTLKLII 700
    KADVQGSIEA LAHSILNIRS EKVDVEILSS GVGDISESDI RLASASKATV 750
    IGFHTSVESH AEPLIKNLNV KVCLFDIIYH AVDAIKEIMT GLLDPIAEEK 800
    NLGAAEIKAT FKSSQLGTIY GCLVTEGTVV RNQKIRIIRD KEVLWKGSLS 850
    SLKRLKEDVK EVKKGMECGI LLDNYQQAQV GDILQCYEVI YHPQTL 896
    Length:896
    Mass (Da):97,378
    Last modified:February 26, 2008 - v1
    Checksum:i345BA0E5ED81170D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM884177 Genomic DNA. Translation: CAP06745.1.
    RefSeqiYP_001653447.1. NC_010280.2.

    Genome annotation databases

    EnsemblBacteriaiCAP06745; CAP06745; CTLon_0347.
    GeneIDi5858942.
    KEGGictl:CTLon_0347.
    PATRICi20382279. VBIChlTra68089_0379.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM884177 Genomic DNA. Translation: CAP06745.1 .
    RefSeqi YP_001653447.1. NC_010280.2.

    3D structure databases

    ProteinModelPortali B0BB83.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 471473.CTLon_0347.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAP06745 ; CAP06745 ; CTLon_0347 .
    GeneIDi 5858942.
    KEGGi ctl:CTLon_0347.
    PATRICi 20382279. VBIChlTra68089_0379.

    Phylogenomic databases

    eggNOGi COG0532.
    HOGENOMi HOG000076906.
    KOi K02519.
    OMAi MTNKLRI.
    OrthoDBi EOG67HJSV.

    Enzyme and pathway databases

    BioCyci CTRA471473:GHJK-368-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.10050. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00100_B. IF_2_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR006847. IF2_N.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR000178. TF_IF2_bacterial-like.
    IPR015760. TIF_IF2.
    IPR023115. TIF_IF2_dom3.
    IPR009000. Transl_B-barrel.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    PANTHERi PTHR23115:SF41. PTHR23115:SF41. 1 hit.
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 2 hits.
    PF11987. IF-2. 1 hit.
    PF04760. IF2_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50447. SSF50447. 2 hits.
    SSF52156. SSF52156. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00487. IF-2. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51722. G_TR_2. 1 hit.
    PS01176. IF2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: UCH-1/proctitis.

    Entry informationi

    Entry nameiIF2_CHLTB
    AccessioniPrimary (citable) accession number: B0BB83
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3