B0BAM7 (IPYR_CHLTB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inorganic pyrophosphatase
EC=3.6.1.1

Alternative name(s):
Pyrophosphate phospho-hydrolase
Short name=PPase

Gene names

Name:	ppa
Ordered Locus Names:	CTLon_0141

Organism

Chlamydia trachomatis (strain L2b/UCH-1/proctitis) [Complete proteome] [HAMAP]

Taxonomic identifier

471473 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia

Protein attributes

Sequence length	209 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Diphosphate + H2O = 2 phosphate. HAMAP MF_00209
Cofactor	Binds 4 magnesium ions per subunit. Other metal ions can support activity, but at a lower rate. Two magnesium ions are required for the activation of the enzyme and are present before substrate binds, two additional magnesium ions form complexes with substrate and product By similarity.
Subcellular location	Cytoplasm By similarity HAMAP MF_00209.
Sequence similarities	Belongs to the PPase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphate metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	inorganic diphosphatase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 209	209	Inorganic pyrophosphatase HAMAP MF_00209		PRO_1000099657
Sites
	Metal binding	92	1	Magnesium 1 By similarity
	Metal binding	97	1	Magnesium 1 By similarity
	Metal binding	97	1	Magnesium 2 By similarity
	Metal binding	130	1	Magnesium 1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	B0BAM7-1 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: 7694093E5ADF0275	FASTA	209	23,391
	10 20 30 40 50 60 MSKTPLSIAH PWHGPVLTRD DYESLCCYIE ITPADSVKFE LDKETGILKV DRPQKFSNFC 70 80 90 100 110 120 PCLYGLLPKT YCGDLSGEYS GQQSNRENIK GDGDPLDICV LTEKNITQGN ILLQARPIGG 130 140 150 160 170 180 IRILDSEEAD DKIIAVLEDD LVYGNIEDIS ECPGTVLDMI QHYFLTYKAT PESLIQAKPA 190 200 KIEIVGLYGK KEAQKVIRLA HEDYCNLFM

References

[1]

"Chlamydia trachomatis: genome sequence analysis of lymphogranuloma venereum isolates." Thomson N.R., Holden M.T.G., Carder C., Lennard N., Lockey S.J., Marsh P., Skipp P., O'Connor C.D., Goodhead I., Norbertzcak H., Harris B., Ormond D., Rance R., Quail M.A., Parkhill J., Stephens R.S., Clarke I.N. Genome Res. 18:161-171(2008) [PubMed: 18032721] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM884177 Genomic DNA. Translation: CAP06539.1.
RefSeq	YP_001653244.1.
3D structure databases
ProteinModelPortal	B0BAM7.
SMR	B0BAM7. Positions 10-205.
ModBase	Search...
Genome annotation databases
GeneID	5859351.
GenomeReviews	Gene locus CTLon_0141 in contig AM884177_GR.
KEGG	ctl:CTLon_0141.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG529150.
OMA	PVALMKM.
ProtClustDB	PRK00642.
Enzyme and pathway databases
BioCyc	CTRA471473:CTLON_0141-MONOMER.
Family and domain databases
HAMAP	MF_00209. Inorganic_PPase. [Tree]
InterPro	IPR008162. Pyrophosphatase. [Graphical view]
Gene3D	G3DSA:3.90.80.10. Pyrophosphatase. 1 hit.
PANTHER	PTHR10286. Pyrophosphatase. 1 hit.
Pfam	PF00719. Pyrophosphatase. 1 hit. [Graphical view]
SUPFAM	SSF50324. Pyrophosphatase. 1 hit.
PROSITE	PS00387. PPASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IPYR_CHLTB

Accession

Primary (citable) accession number: B0BAM7

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	February 26, 2008
Last modified:	August 10, 2010
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)