B0B9Y4 (LPXA_CHLTB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
Short name=UDP-N-acetylglucosamine acyltransferase
EC=2.3.1.129

Gene names

Name:	lpxA
Ordered Locus Names:	CTLon_0788

Organism

Chlamydia trachomatis serovar L2b (strain UCH-1/proctitis) [Complete proteome] [HAMAP]

Taxonomic identifier

471473 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00387
Catalytic activity	(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetylglucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine. HAMAP MF_00387
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6. HAMAP MF_00387
Subunit structure	Homotrimer By similarity. HAMAP MF_00387
Subcellular location	Cytoplasm By similarity HAMAP MF_00387.
Sequence similarities	Belongs to the transferase hexapeptide repeat family. LpxA subfamily.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Cellular component	Cytoplasm
Domain	Repeat
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 280	280	Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase HAMAP MF_00387		PRO_1000122696

Sequences

	Sequence		Length	Mass (Da)
	B0B9Y4 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: 362F2E9AC33A4F34	FASTA	280	30,724
	10 20 30 40 50 60 MTNIHPTAIV EDGARIGNNV TIEPYAIVKK SVTLCDDVVV KSYAYIDGFT TIGRGTTVWP 70 80 90 100 110 120 SAMIGNKPQD LKFKGEKTFV EIGEHCEIRE FAMITSSTFE GTTVSIGNNC LIMPWAHIAH 130 140 150 160 170 180 NCSVGNNVVF STHVQLAGHV QVGDCVTIGS MVGVHQFVRI GSYSMVGAMS GIRRDIPPFT 190 200 210 220 230 240 IGTGNPYALG GINKVGLQRR QVSFETRLAL IKTFKRVFRS DESFQASLES VLEDFGEVPE 250 260 270 280 VRHFVEFCRQ PSKRGIERGV DCEASLEEPI DKKEGAFVES

References

[1]

"Chlamydia trachomatis: genome sequence analysis of lymphogranuloma venereum isolates." Thomson N.R., Holden M.T.G., Carder C., Lennard N., Lockey S.J., Marsh P., Skipp P., O'Connor C.D., Goodhead I., Norbertzcak H., Harris B., Ormond D., Rance R., Quail M.A., Parkhill J., Stephens R.S., Clarke I.N. Genome Res. 18:161-171(2008) [PubMed: 18032721] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: UCH-1/proctitis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM884177 Genomic DNA. Translation: CAP07185.1.
RefSeq	YP_001653876.1. NC_010280.2.
3D structure databases
ProteinModelPortal	B0B9Y4.
ModBase	Search...
Protein-protein interaction databases
STRING	B0B9Y4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5859493.
GenomeReviews	Gene locus CTLon_0788 in contig AM884177_GR.
KEGG	ctl:CTLon_0788.
PATRIC	20383265. VBIChlTra68089_0853.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG659295.
OMA	GDKNLLM.
ProtClustDB	PRK05289.
Enzyme and pathway databases
BioCyc	CTRA471473:CTLON_0788-MONOMER.
Family and domain databases
HAMAP	MF_00387. LpxA. [Tree]
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR010137. Lipid_A_lpxA. IPR011004. Trimer_LpxA-like. [Graphical view]
KO	K00677.
Pfam	PF00132. Hexapep. 5 hits. [Graphical view]
PIRSF	PIRSF000456. UDP-GlcNAc_acltr. 1 hit.
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01852. Lipid_A_lpxA. 1 hit.
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LPXA_CHLTB

Accession

Primary (citable) accession number: B0B9Y4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 26, 2008
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program