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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamyl-tRNA reductase (hemA)
  2. Glutamate-1-semialdehyde 2,1-aminomutase (hemL)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processPorphyrin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciCTRA471472:G1GJT-485-MONOMER
UniPathwayiUPA00251; UER00317

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:CTL0462
OrganismiChlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B)
Taxonomic identifieri471472 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000795 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001218671 – 422Glutamate-1-semialdehyde 2,1-aminomutaseAdd BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei258N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiB0B9W0

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB0B9W0
SMRiB0B9W0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000020210
KOiK01845
OMAiWGPLIFG

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

B0B9W0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHLFSKACQ YFPGGVNSPV RACRAVNITP PIVARASKEV FIDSLDKTFI
60 70 80 90 100
DFCGSWGSLI HGHSHPKICA AIRQGLERGS SYGLTSEQEI LFAEEIFSYL
110 120 130 140 150
GLETNYKIRF MSTGSEATMT AVRLARGITG RPIIIKFLGC YHGHADTFLQ
160 170 180 190 200
EKPFSHTSLD TLDLAHPLTL SLPFNDFPLF QTVMNSLGHK VAGVIFEPVC
210 220 230 240 250
ANMGVILPVP DFIEGVIQTC QQTGSFSIMD EVVTGFRVAQ GGAAALYHVK
260 270 280 290 300
PDILVFGKIL GGGLPASAVV APKDIMDHLA PEGKIFQAGT LSGNPLAMIA
310 320 330 340 350
GKVSVNLCRE QGFYTQLATI EQNFLSPIEH MIRTTGIPVT LVRYGSLFSF
360 370 380 390 400
FFNPNRPNNL ADAQLSDIEA FQKFYQSAFS KGVYLSPSPF EASFLSAAHS
410 420
MESLDYAQTA LIESLEQVFS LV
Length:422
Mass (Da):45,940
Last modified:February 26, 2008 - v1
Checksum:i966AE029D1A07411
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM884176 Genomic DNA Translation: CAP03901.1
RefSeqiWP_009873641.1, NC_010287.1
YP_001654538.1, NC_010287.1

Genome annotation databases

EnsemblBacteriaiCAP03901; CAP03901; CTL0462
GeneIDi5858804
KEGGictb:CTL0462
PATRICifig|471472.4.peg.497

Similar proteinsi

Entry informationi

Entry nameiGSA_CHLT2
AccessioniPrimary (citable) accession number: B0B9W0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 26, 2008
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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