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B0B9W0

- GSA_CHLT2

UniProt

B0B9W0 - GSA_CHLT2

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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene
hemL, CTL0462
Organism
Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciCTRA471472:GJ9M-485-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Ordered Locus Names:CTL0462
OrganismiChlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B)
Taxonomic identifieri471472 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
ProteomesiUP000000795: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotationPRO_1000121867Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei258 – 2581N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi471472.CTL0462.

Structurei

3D structure databases

ProteinModelPortaliB0B9W0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiRAIKPYP.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0B9W0-1 [UniParc]FASTAAdd to Basket

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MSHLFSKACQ YFPGGVNSPV RACRAVNITP PIVARASKEV FIDSLDKTFI    50
DFCGSWGSLI HGHSHPKICA AIRQGLERGS SYGLTSEQEI LFAEEIFSYL 100
GLETNYKIRF MSTGSEATMT AVRLARGITG RPIIIKFLGC YHGHADTFLQ 150
EKPFSHTSLD TLDLAHPLTL SLPFNDFPLF QTVMNSLGHK VAGVIFEPVC 200
ANMGVILPVP DFIEGVIQTC QQTGSFSIMD EVVTGFRVAQ GGAAALYHVK 250
PDILVFGKIL GGGLPASAVV APKDIMDHLA PEGKIFQAGT LSGNPLAMIA 300
GKVSVNLCRE QGFYTQLATI EQNFLSPIEH MIRTTGIPVT LVRYGSLFSF 350
FFNPNRPNNL ADAQLSDIEA FQKFYQSAFS KGVYLSPSPF EASFLSAAHS 400
MESLDYAQTA LIESLEQVFS LV 422
Length:422
Mass (Da):45,940
Last modified:February 26, 2008 - v1
Checksum:i966AE029D1A07411
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM884176 Genomic DNA. Translation: CAP03901.1.
RefSeqiYP_001654538.1. NC_010287.1.

Genome annotation databases

EnsemblBacteriaiCAP03901; CAP03901; CTL0462.
GeneIDi5858804.
KEGGictb:CTL0462.
PATRICi20376458. VBIChlTra32542_0497.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM884176 Genomic DNA. Translation: CAP03901.1 .
RefSeqi YP_001654538.1. NC_010287.1.

3D structure databases

ProteinModelPortali B0B9W0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 471472.CTL0462.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAP03901 ; CAP03901 ; CTL0462 .
GeneIDi 5858804.
KEGGi ctb:CTL0462.
PATRICi 20376458. VBIChlTra32542_0497.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi RAIKPYP.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci CTRA471472:GJ9M-485-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 434/Bu / ATCC VR-902B.

Entry informationi

Entry nameiGSA_CHLT2
AccessioniPrimary (citable) accession number: B0B9W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 26, 2008
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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