B0B9T2 (KDSB_CHLT2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-deoxy-manno-octulosonate cytidylyltransferase
EC=2.7.7.38

Alternative name(s):
CMP-2-keto-3-deoxyoctulosonic acid synthase
Short name=CKS
Short name=CMP-KDO synthase

Gene names

Name:	kdsB
Ordered Locus Names:	CTL0434

Organism

Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B) [Complete proteome] [HAMAP]

Taxonomic identifier

471472 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria By similarity. HAMAP MF_00057
Catalytic activity	CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate. HAMAP MF_00057
Pathway	Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1. HAMAP MF_00057 Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP MF_00057
Subcellular location	Cytoplasm Potential HAMAP MF_00057.
Sequence similarities	Belongs to the KdsB family.

Ontologies

Keywords
Biological process	Lipopolysaccharide biosynthesis
Cellular component	Cytoplasm
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipopolysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-deoxy-manno-octulosonate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	3-deoxy-manno-octulosonate cytidylyltransferase HAMAP MF_00057		PRO_1000091864

Sequences

	Sequence		Length	Mass (Da)
	B0B9T2 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: 77F0221F329516EB	FASTA	254	28,009
	10 20 30 40 50 60 MFAFLTSKKV GILPSRWGSS RFPGKPLAKI LGKTLVQRSY ENALSSQSLD CVVVATDDQR 70 80 90 100 110 120 IFDHVVEFGG LCVMTSTSCA NGTERVEEVV SRHFPQAEIV VNIQGDEPCL SPTVIDGLVS 130 140 150 160 170 180 TLENNPAADM VTPVTETTDP EAILTDHKVK CVFDKNGKAL YFSRSAIPHN FKHPTPIYLH 190 200 210 220 230 240 IGVYAFRKAF LSEYVKIPPS SLSLAEDLEQ LRVLETGRSI YVHVVQNATG PSVDYPEDIT 250 KVEQYLLCLS KASF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of the Chlamydia trachomatis gene for CTP synthetase." Tipples G., McClarty G. J. Biol. Chem. 270:7908-7914(1995) [PubMed: 7713886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Chlamydia trachomatis: genome sequence analysis of lymphogranuloma venereum isolates." Thomson N.R., Holden M.T.G., Carder C., Lennard N., Lockey S.J., Marsh P., Skipp P., O'Connor C.D., Goodhead I., Norbertzcak H., Harris B., Ormond D., Rance R., Quail M.A., Parkhill J., Stephens R.S., Clarke I.N. Genome Res. 18:161-171(2008) [PubMed: 18032721] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 434/Bu / ATCC VR-902B.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U15192 Genomic DNA. Translation: AAA80194.1. AM884176 Genomic DNA. Translation: CAP03873.1.
PIR	A56447.
RefSeq	YP_001654510.1. NC_010287.1.
3D structure databases
ProteinModelPortal	B0B9T2.
ModBase	Search...
Protein-protein interaction databases
STRING	B0B9T2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5858046.
GenomeReviews	Gene locus CTL0434 in contig AM884176_GR.
KEGG	ctb:CTL0434.
PATRIC	20376398. VBIChlTra32542_0469.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG637773.
OMA	INVQADE.
ProtClustDB	PRK05450.
Enzyme and pathway databases
BioCyc	CTRA471472:CTL0434-MONOMER.
Family and domain databases
HAMAP	MF_00057. CMP-KDO_synth. [Tree]
InterPro	IPR003329. Cytidylyl_trans. IPR004528. KdsB. [Graphical view]
KO	K00979.
Pfam	PF02348. CTP_transf_3. 1 hit. [Graphical view]
TIGRFAMs	TIGR00466. KdsB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KDSB_CHLT2

Accession

Primary (citable) accession number: B0B9T2
Secondary accession number(s): O84185, Q59320

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	February 26, 2008
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program