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Protein

Release factor glutamine methyltransferase

Gene

prmC

Organism
Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + [peptide chain release factor 1 or 2]-L-glutamine = S-adenosyl-L-homocysteine + [peptide chain release factor 1 or 2]-N(5)-methyl-L-glutamine.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei140S-adenosyl-L-methionineBy similarity1
Binding sitei181S-adenosyl-L-methionineBy similarity1

GO - Molecular functioni

  • nucleic acid binding Source: InterPro
  • protein-glutamine N-methyltransferase activity Source: UniProtKB
  • protein methyltransferase activity Source: UniProtKB
  • S-adenosylmethionine-dependent methyltransferase activity Source: UniProtKB

GO - Biological processi

  • peptidyl-glutamine methylation Source: UniProtKB
  • protein methylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BRENDAi2.1.1.297. 1315.

Names & Taxonomyi

Protein namesi
Recommended name:
Release factor glutamine methyltransferase (EC:2.1.1.297)
Short name:
RF MTase
Alternative name(s):
N5-glutamine methyltransferase PrmC
Protein-(glutamine-N5) MTase PrmC
Protein-glutamine N-methyltransferase PrmC
Gene namesi
Name:prmC
Ordered Locus Names:CTL0279
OrganismiChlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B)
Taxonomic identifieri471472 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000795 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004145091 – 290Release factor glutamine methyltransferaseAdd BLAST290

Structurei

3D structure databases

ProteinModelPortaliB0B9D1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni181 – 184Substrate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000076274.
KOiK02493.
OMAiQYCTNKA.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_02126. RF_methyltr_PrmC. 1 hit.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR004556. Modification_methylase_HemK.
IPR019874. Release_fac_Glu-N5_MeTfrase.
IPR029063. SAM-dependent_MTases.
IPR007848. Small_mtfrase_dom.
[Graphical view]
PfamiPF05175. MTS. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00536. hemK_fam. 1 hit.
TIGR03534. RF_mod_PrmC. 1 hit.

Sequencei

Sequence statusi: Complete.

B0B9D1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLLREASE YLLSRGIRFP QREAEDILMD LLEISSRSAL HQAKLSSEEQ
60 70 80 90 100
SLYWKRLRKR GDRCPTAYIH GKVHFLGVEL QVTPQVLIPR QETEIFVEQI
110 120 130 140 150
IGYLQMHKEK TTFYDVCCGS GCIGLAVRKH CPHVRVTLSD ISPEALAIAE
160 170 180 190 200
SNARSNALAV DFLLGDLFDP FSFPADVLVC NPPYLSYKEF FESDPEVRCH
210 220 230 240 250
EPWKALVGGV SGLEFYHRIA THIHKILVSG GVGWLEIGST QGEDVKQIFH
260 270 280 290
AKGIRGRVLK DYAQLDRFFF LENQANDAVS SGEVSGFSER
Length:290
Mass (Da):32,772
Last modified:February 26, 2008 - v1
Checksum:i0230007284D58217
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY600244 Genomic DNA. Translation: AAT35566.1.
AM884176 Genomic DNA. Translation: CAP03718.1.
RefSeqiWP_009873502.1. NC_010287.1.
YP_001654363.1. NC_010287.1.

Genome annotation databases

EnsemblBacteriaiCAP03718; CAP03718; CTL0279.
GeneIDi5858726.
KEGGictb:CTL0279.
PATRICi20376054. VBIChlTra32542_0303.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY600244 Genomic DNA. Translation: AAT35566.1.
AM884176 Genomic DNA. Translation: CAP03718.1.
RefSeqiWP_009873502.1. NC_010287.1.
YP_001654363.1. NC_010287.1.

3D structure databases

ProteinModelPortaliB0B9D1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAP03718; CAP03718; CTL0279.
GeneIDi5858726.
KEGGictb:CTL0279.
PATRICi20376054. VBIChlTra32542_0303.

Phylogenomic databases

HOGENOMiHOG000076274.
KOiK02493.
OMAiQYCTNKA.

Enzyme and pathway databases

BRENDAi2.1.1.297. 1315.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_02126. RF_methyltr_PrmC. 1 hit.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR004556. Modification_methylase_HemK.
IPR019874. Release_fac_Glu-N5_MeTfrase.
IPR029063. SAM-dependent_MTases.
IPR007848. Small_mtfrase_dom.
[Graphical view]
PfamiPF05175. MTS. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00536. hemK_fam. 1 hit.
TIGR03534. RF_mod_PrmC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPRMC_CHLT2
AccessioniPrimary (citable) accession number: B0B9D1
Secondary accession number(s): Q6J519
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: February 26, 2008
Last modified: November 2, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.