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Protein

Release factor glutamine methyltransferase

Gene

prmC

Organism
Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.1 Publication

Catalytic activityi

S-adenosyl-L-methionine + [peptide chain release factor 1 or 2]-L-glutamine = S-adenosyl-L-homocysteine + [peptide chain release factor 1 or 2]-N5-methyl-L-glutamine.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei140S-adenosyl-L-methionineBy similarity1
Binding sitei181S-adenosyl-L-methionineBy similarity1

GO - Molecular functioni

  • nucleic acid binding Source: InterPro
  • protein-(glutamine-N5) methyltransferase activity Source: UniProtKB-EC
  • protein-glutamine N-methyltransferase activity Source: UniProtKB
  • protein methyltransferase activity Source: UniProtKB
  • S-adenosylmethionine-dependent methyltransferase activity Source: UniProtKB

GO - Biological processi

  • peptidyl-glutamine methylation Source: UniProtKB
  • protein methylation Source: UniProtKB

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciCTRA471472:G1GJT-294-MONOMER
BRENDAi2.1.1.297 1315

Names & Taxonomyi

Protein namesi
Recommended name:
Release factor glutamine methyltransferase (EC:2.1.1.297)
Short name:
RF MTase
Alternative name(s):
N5-glutamine methyltransferase PrmC
Protein-(glutamine-N5) MTase PrmC
Protein-glutamine N-methyltransferase PrmC
Gene namesi
Name:prmC
Ordered Locus Names:CTL0279
OrganismiChlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B)
Taxonomic identifieri471472 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000795 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004145091 – 290Release factor glutamine methyltransferaseAdd BLAST290

Proteomic databases

PRIDEiB0B9D1

Structurei

3D structure databases

ProteinModelPortaliB0B9D1
SMRiB0B9D1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni181 – 184Substrate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000076274
KOiK02493
OMAiMLVSNPP

Family and domain databases

HAMAPiMF_02126 RF_methyltr_PrmC, 1 hit
InterProiView protein in InterPro
IPR002052 DNA_methylase_N6_adenine_CS
IPR004556 Modification_methylase_HemK
IPR019874 Release_fac_Glu-N5_MeTfrase
IPR029063 SAM-dependent_MTases
IPR007848 Small_mtfrase_dom
PfamiView protein in Pfam
PF05175 MTS, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00536 hemK_fam, 1 hit
TIGR03534 RF_mod_PrmC, 1 hit

Sequencei

Sequence statusi: Complete.

B0B9D1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLLREASE YLLSRGIRFP QREAEDILMD LLEISSRSAL HQAKLSSEEQ
60 70 80 90 100
SLYWKRLRKR GDRCPTAYIH GKVHFLGVEL QVTPQVLIPR QETEIFVEQI
110 120 130 140 150
IGYLQMHKEK TTFYDVCCGS GCIGLAVRKH CPHVRVTLSD ISPEALAIAE
160 170 180 190 200
SNARSNALAV DFLLGDLFDP FSFPADVLVC NPPYLSYKEF FESDPEVRCH
210 220 230 240 250
EPWKALVGGV SGLEFYHRIA THIHKILVSG GVGWLEIGST QGEDVKQIFH
260 270 280 290
AKGIRGRVLK DYAQLDRFFF LENQANDAVS SGEVSGFSER
Length:290
Mass (Da):32,772
Last modified:February 26, 2008 - v1
Checksum:i0230007284D58217
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY600244 Genomic DNA Translation: AAT35566.1
AM884176 Genomic DNA Translation: CAP03718.1
RefSeqiWP_009873502.1, NC_010287.1
YP_001654363.1, NC_010287.1

Genome annotation databases

EnsemblBacteriaiCAP03718; CAP03718; CTL0279
GeneIDi35551879
5858726
KEGGictb:CTL0279
PATRICifig|471472.4.peg.303

Similar proteinsi

Entry informationi

Entry nameiPRMC_CHLT2
AccessioniPrimary (citable) accession number: B0B9D1
Secondary accession number(s): Q6J519
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: February 26, 2008
Last modified: May 23, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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