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B0B858 (HEMH_CHLT2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:CTL0746
OrganismChlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B) [Complete proteome] [HAMAP]
Taxonomic identifier471472 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Ferrochelatase HAMAP MF_00323
PRO_1000116036

Sites

Metal binding1841Iron By similarity
Metal binding2591Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
B0B858 [UniParc].

Last modified February 26, 2008. Version 1.
Checksum: 6FD97BC2C7C30793

FASTA31435,608
        10         20         30         40         50         60 
MVTYLLANFG GPRTSQEIVS FLQALLTDRD VTGGMIPSVL HRPLFSYIAK RRAPHVARQY 

        70         80         90        100        110        120 
AYLGGGSPIF QDTERLAQNL SQELQASVIP FHRYLPETHR ETLQALQESQ GSIVGIPLFP 

       130        140        150        160        170        180 
HYTFAVTGSI IRFFLQHLPE KPISWITQFG VHPQFVSCMQ QHIRDCLAAQ QIAVEDCYFL 

       190        200        210        220        230        240 
FSVHGLPQRH IRLGDPYAQQ CQASFEALRG ELEGEIAFQS KFGIGKWLDP STQEVCQSLR 

       250        260        270        280        290        300 
TKKRYIVIVP FGFVSDHIET LYEIDHLYVP ILLQKEYRVV RIPAINASSR WVSSLAAIVR 

       310 
SSPQETSLEP LLMP

« Hide

References

[1]"Chlamydia trachomatis: genome sequence analysis of lymphogranuloma venereum isolates."
Thomson N.R., Holden M.T.G., Carder C., Lennard N., Lockey S.J., Marsh P., Skipp P., O'Connor C.D., Goodhead I., Norbertzcak H., Harris B., Ormond D., Rance R., Quail M.A., Parkhill J., Stephens R.S., Clarke I.N.
Genome Res. 18:161-171(2008) [PubMed: 18032721] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 434/Bu / ATCC VR-902B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM884176 Genomic DNA. Translation: CAP04184.1.
RefSeqYP_001654817.1. NC_010287.1.

3D structure databases

ProteinModelPortalB0B858.
ModBaseSearch...

Protein-protein interaction databases

STRINGB0B858.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5858375.
GenomeReviewsGene locus CTL0746 in contig AM884176_GR.
KEGGctb:CTL0746.
PATRIC20377090. VBIChlTra32542_0802.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG697135.
OMAKPWLGGQ.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycCTRA471472:CTL0746-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_CHLT2
AccessionPrimary (citable) accession number: B0B858
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 26, 2008
Last modified: January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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