Reviewed, UniProtKB/Swiss-Prot B0B803 (CLPP1_CHLT2)

Names and origin

Protein names

Recommended name:
    ATP-dependent Clp protease proteolytic subunit 1
    EC=3.4.21.92
Alternative name(s):
    Endopeptidase Clp 1

Gene names

Name:	clpP1
Ordered Locus Names:	CTL0690

Organism

Chlamydia trachomatis (strain L2/434/Bu / ATCC VR902B) [Complete proteome] [HAMAP]

Taxonomic identifier

471472 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia

Protein attributes

Sequence length	192 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity.
Catalytic activity	Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). HAMAP MF_00444
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the peptidase S14 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase Protease Serine protease
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.2
	Chain	2 – 192	191	ATP-dependent Clp protease proteolytic subunit 1 HAMAP MF_00444		PRO_0000340090
Sites
	Active site	92	1	By similarity
	Active site	117	1	By similarity
Experimental info
	Sequence conflict	8	1	H → M AA sequence Ref.2

Sequences

	Sequence		Length	Mass (Da)
	B0B803-1 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: 589EF06C344F20EF	FASTA	192	21,073
	10 20 30 40 50 60 MPEGEMMHKL QDVIDRKLLD SRRIFFSEPV TEKSAAEAIK KLWYLELTNP GQPIVFVINS 70 80 90 100 110 120 PGGSVDAGFA VWDQIKMISS PLTTVVTGLA ASMGSVLSLC AVPGRRFATP HARIMIHQPS 130 140 150 160 170 180 IGGTITGQAT DLDIHAREIL KTKARIIDVY VEATGQSPEV IEKAIDRDMW MSANEAMEFG 190 LLDGILFSFN DL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Chlamydia trachomatis: genome sequence analysis of lymphogranuloma venereum isolates." Thomson N.R., Holden M.T.G., Carder C., Lennard N., Lockey S.J., Marsh P., Skipp P., O'Connor C.D., Goodhead I., Norbertzcak H., Harris B., Ormond D., Rance R., Quail M.A., Parkhill J., Stephens R.S., Clarke I.N. Genome Res. 18:161-171(2008) [PubMed: 18032721] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Bini L., Santucci A., Magi B., Marzocchi B., Sanchez-Campillo M., Comanducci M., Christianen G., Birkelund S., Vtretou E., Ratti G., Pallini V. Submitted (SEP-1994) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-11.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM884176 Genomic DNA. Translation: CAP04129.1.
RefSeq	YP_001654762.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5858690.
GenomeReviews	Gene locus CTL0690 in contig AM884176_GR.
KEGG	ctb:CTL0690.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	B0B803. TPHSRIM.
Family and domain databases
HAMAP	MF_00444. [Tree]
InterPro	IPR001907. Pept_S14_ClpP. IPR018215. Pept_S14_ClpP_CS. [Graphical view]
PANTHER	PTHR10381. Pept_S14_ClpP. 1 hit.
Pfam	PF00574. CLP_protease. 1 hit. [Graphical view]
PRINTS	PR00127. CLPPROTEASEP.
PROSITE	PS00382. CLP_PROTEASE_HIS. 1 hit. PS00381. CLP_PROTEASE_SER. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CLPP1_CHLT2

Accession

Primary (citable) accession number: B0B803

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	February 26, 2008
Last modified:	June 16, 2009
This is version 10 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)