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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. Probable ATP-dependent 6-phosphofructokinase (pfkA), 6-phosphofructokinase (pfkA_2)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei378UniRule annotation1
Active sitei493UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciCTRA471472:G1GJT-663-MONOMER
UniPathwayiUPA00109; UER00181
UPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:CTL0633
OrganismiChlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B)
Taxonomic identifieri471472 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000000795 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001257051 – 525Glucose-6-phosphate isomeraseAdd BLAST525

Proteomic databases

PRIDEiB0B7U7

Structurei

3D structure databases

ProteinModelPortaliB0B7U7
SMRiB0B7U7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000261370
KOiK01810
OMAiTNSQHAF

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
Gene3Di1.10.1390.101 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR023096 G6P_Isomerase_C
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

B0B7U7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMGKGFLDCE SLVALQEMAL HPIDLTASGC LSEERIQKNS LSVEGFTYSY
60 70 80 90 100
ATERVDDRCL EALQGLTEER ELIKQMECMQ QGAIMNRIEG FQSESRPVLH
110 120 130 140 150
TATRAWVRDQ DLHEEAAAIA RHSKEEALRL AEFLYIARAK FSTLVQIGIG
160 170 180 190 200
GSELGPKAMY FAMQGSCPSD KRIFFVSNID PDNAAEVLRE IDLEQTLVVV
210 220 230 240 250
VSKSGTTLEP AANEELFRQA YQNKGLSIAE HFVAVTSQGS PMDDKSRYLE
260 270 280 290 300
VFHLWDSIGG RFSATSMVGG VVLGFAFGYE AFIEFLQGAA AIDAHALTPK
310 320 330 340 350
MRENLPLLSA MLGVWNRNLL GYPTTAVIPY STGLKYFTAH LQQCGMESNG
360 370 380 390 400
KSISREGKEI SFRTSPIIWG DVGTNCQHSF FQSLHQGTDI VPVEFIGFLH
410 420 430 440 450
NQRGLDCVLS GSSSSQKLFA NLVAQSLALA QGRDNANPNK RFKGNSPSSI
460 470 480 490 500
LVAQQLSPRI AGSLLAFYEH KFAFQGFCWG INSFDQEGVS LGKELATQII
510 520
GIMSGNAPVE FPEARGVLRL FNVLT
Length:525
Mass (Da):57,700
Last modified:February 26, 2008 - v1
Checksum:iBF49762A614C6ADE
GO

Sequence cautioni

The sequence AAA75628 differs from that shown. Reason: Frameshift at positions 469, 500 and 524.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti135 – 145YIARAKFSTLV → ACLQVDSRGSP in AAA75628 (PubMed:7543468).CuratedAdd BLAST11
Sequence conflicti150G → K in AAA75628 (PubMed:7543468).Curated1
Sequence conflicti189R → L in AAA75628 (PubMed:7543468).Curated1
Sequence conflicti247R → A in AAA75628 (PubMed:7543468).Curated1
Sequence conflicti382Missing in AAA75628 (PubMed:7543468).Curated1
Sequence conflicti412S → T in AAA75628 (PubMed:7543468).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM884176 Genomic DNA Translation: CAP04073.1
L40822 Genomic DNA Translation: AAA75628.1 Frameshift.
PIRiF71521
RefSeqiWP_009873769.1, NC_010287.1
YP_001654706.1, NC_010287.1

Genome annotation databases

EnsemblBacteriaiCAP04073; CAP04073; CTL0633
GeneIDi5858722
KEGGictb:CTL0633
PATRICifig|471472.4.peg.683

Similar proteinsi

Entry informationi

Entry nameiG6PI_CHLT2
AccessioniPrimary (citable) accession number: B0B7U7
Secondary accession number(s): O84382, Q46402
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 26, 2008
Last modified: February 28, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome