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B0B7Q0 (KPYK_CHLT2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyruvate kinase
Short name=PK
EC=2.7.1.40
Gene names
Name:pyk
Synonyms:pykF
Ordered Locus Names:CTL0586
OrganismChlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B) [Complete proteome] [HAMAP]
Taxonomic identifier471472 [NCBI]
Taxonomic lineageBacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia ›

Protein attributes

Sequence length485 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactor

Magnesium.

Potassium.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the pyruvate kinase family.

Sequence caution

The sequence AAB41226.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 485485Pyruvate kinase
PRO_0000391804

Sites

Metal binding351Potassium By similarity
Metal binding371Potassium By similarity
Metal binding671Potassium By similarity
Metal binding681Potassium; via carbonyl oxygen By similarity
Metal binding2211Magnesium By similarity
Metal binding2451Magnesium By similarity
Binding site331Substrate By similarity
Binding site2441Substrate; via amide nitrogen By similarity
Binding site2451Substrate; via amide nitrogen By similarity
Binding site2771Substrate By similarity
Site2191Transition state stabilizer By similarity

Experimental info

Sequence conflict104 – 11310GVTLYPSCVF → ALLFIQVVYS in AAB41226. Ref.1
Sequence conflict362 – 3665IGFSG → NWVFW in AAB41226. Ref.1

Sequences

Sequence LengthMass (Da)Tools
B0B7Q0 [UniParc].

Last modified February 26, 2008. Version 1.
Checksum: 37001F8B1F40FF4C

FASTA48553,631
        10         20         30         40         50         60 
MIARTKIICT IGPATNTPEM LEKLLDAGMN VARLNFSHGT HESHGRTIAI LKELREKRQV 

        70         80         90        100        110        120 
PLAIMLDTKG PEIRLGQVES PIKVQPGDRL TLVSKEILGS KESGVTLYPS CVFPYVRERA 

       130        140        150        160        170        180 
PVLIDDGYIQ AVVVNAQEHM VEIEFQNSGE IKSNKSLSIK DIDVALPFMT EKDIADLKFG 

       190        200        210        220        230        240 
VEQELDLIAA SFVRCNEDID SMRKVLESFG RPNMPIIAKI ENHLGVQNFQ EIARAADGIM 

       250        260        270        280        290        300 
IARGDLGIEL SIVEVPGLQK FMARASRETG RFCITATQML ESMIRNPLPT RAEVSDVANA 

       310        320        330        340        350        360 
IYDGTSAVML SGETASGAHP VHAVKTMRSI IQETEKTFDY HAFFQLNDKN SALKVSPYLE 

       370        380        390        400        410        420 
AIGFSGIQIA EKASAKAIIV YTQTGGSPMF LSKYRPYLPI IAVTPNRNVY YRLAVEWGVY 

       430        440        450        460        470        480 
PMLTLESNRT VWRHQACVYG VEKGILSNYD KILVFSRGAG MQDTNNLTLT TVHDALSPSL 


DEIVP

« Hide

References

« Hide 'large scale' references
[1]"Glucose metabolism in Chlamydia trachomatis: the 'energy parasite' hypothesis revisited."
Iliffe-Lee E.R., McClarty G.
Mol. Microbiol. 33:177-187(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Chlamydia trachomatis: genome sequence analysis of lymphogranuloma venereum isolates."
Thomson N.R., Holden M.T.G., Carder C., Lennard N., Lockey S.J., Marsh P., Skipp P., O'Connor C.D., Goodhead I., Norbertzcak H., Harris B., Ormond D., Rance R., Quail M.A., Parkhill J., Stephens R.S., Clarke I.N.
Genome Res. 18:161-171(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 434/Bu / ATCC VR-902B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U83196 Genomic DNA. Translation: AAB41226.1. Different initiation.
AM884176 Genomic DNA. Translation: CAP04026.1.
RefSeqYP_001654661.1. NC_010287.1.

3D structure databases

ProteinModelPortalB0B7Q0.
ModBaseSearch...

Protein-protein interaction databases

STRING471472.CTL0586.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAP04026; CAP04026; CTL0586.
GeneID5857956.
KEGGctb:CTL0586.
PATRIC20376736. VBIChlTra32542_0631.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0469.
HOGENOMHOG000021559.
KOK00873.
OMAIVYTESG.
ProtClustDBPRK05826.

Enzyme and pathway databases

BioCycCTRA471472:GJ9M-615-MONOMER.
SABIO-RKB0B7Q0.
UniPathwayUPA00109; UER00188.

Family and domain databases

Gene3D2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERPTHR11817. PTHR11817. 1 hit.
PfamPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSPR01050. PYRUVTKNASE.
SUPFAMSSF50800. PK_B_barrel_like. 1 hit.
SSF52935. Pyruvate_kinase. 1 hit.
SSF51621. Pyrv/PenolPyrv_Kinase_cat. 1 hit.
TIGRFAMsTIGR01064. pyruv_kin. 1 hit.
PROSITEPS00110. PYRUVATE_KINASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPYK_CHLT2
AccessionPrimary (citable) accession number: B0B7Q0
Secondary accession number(s): O84336, P94685
Entry history
Integrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: February 26, 2008
Last modified: May 29, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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