B0B7P9 (DXS_CHLT2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-deoxy-D-xylulose-5-phosphate synthase
EC=2.2.1.7

Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Short name=DXP synthase
Short name=DXPS

Gene names

Name:	dxs
Ordered Locus Names:	CTL0585

Organism

Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B) [Complete proteome] [HAMAP]

Taxonomic identifier

471472 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia/Chlamydophila group › Chlamydia

Protein attributes

Sequence length	640 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity. HAMAP MF_00315
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: InterPro thiamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 640	640	1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315		PRO_1000115730

Sequences

	Sequence		Length	Mass (Da)
	B0B7P9 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: E6E36D1B897F6C8E	FASTA	640	70,668
	10 20 30 40 50 60 MTYSLLPHIH SPQDLHALSL DKLPVLCDEI RNKIIESLSL TGGHLASNLG GVELTVALHY 70 80 90 100 110 120 VFSSPDDQFI FDVGHQSYVH KLLTGRNTEA FSNIRHDNGL SGFTTPQESN HDIFFSGHAG 130 140 150 160 170 180 NALSLALGLA KGSSNSSSHI LPILGDAAFS CGLTLEALNN IPADLSKFII VLNDNQMSIS 190 200 210 220 230 240 ENVGNIPQGI SQWIYPQKIS KLSQKIHSWI QNLPSFLHKK KTLSHKVDIA LKSLSHPLFE 250 260 270 280 290 300 QFGLHYVGPI DGHNVKKLVQ ALQMIKDQPQ PILFHVCTVK GNGLTEAERD PIRYHGVKAH 310 320 330 340 350 360 FQNTSLKKTS GNVELQTPIS FPQHAGNILC RLGKKYPQLQ VVTPAMSLGS CLEDFRKQFP 370 380 390 400 410 420 DRFTDVGIAE GHAVTFSAGI ARSGTPVCCS IYSTFLHRAM DNVFHDVCMQ ELPVIFAIDR 430 440 450 460 470 480 AGLAFHDGRS HHGIYDLGFL CSMPNMVICQ PRNALVLERL FFSSLLWKSP CAIRYPNIPA 490 500 510 520 530 540 NEKASNSSFP FSPILPGEAE ILCQGDDLLL IALGHMCNTA LTVKEHLLDY GISTTVVDPI 550 560 570 580 590 600 FIKPLDRKLL QSLLTHHSKV IILEEHSIHG GLGSEFLLFL NQHNIKADVL SLGVPDMFIP 610 620 630 640 HGNPETILNL IGLTSDHITQ RILSHFKFST PIPIERFFKA

References

[1]

"Chlamydia trachomatis: genome sequence analysis of lymphogranuloma venereum isolates." Thomson N.R., Holden M.T.G., Carder C., Lennard N., Lockey S.J., Marsh P., Skipp P., O'Connor C.D., Goodhead I., Norbertzcak H., Harris B., Ormond D., Rance R., Quail M.A., Parkhill J., Stephens R.S., Clarke I.N. Genome Res. 18:161-171(2008) [PubMed: 18032721] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 434/Bu / ATCC VR-902B.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM884176 Genomic DNA. Translation: CAP04025.1.
RefSeq	YP_001654660.1. NC_010287.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B0B7P9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5858397.
GenomeReviews	Gene locus CTL0585 in contig AM884176_GR.
KEGG	ctb:CTL0585.
PATRIC	20376734. VBIChlTra32542_0630.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG571647.
OMA	QYDISYM.
ProtClustDB	PRK05444.
Enzyme and pathway databases
BioCyc	CTRA471472:CTL0585-MONOMER.
Family and domain databases
HAMAP	MF_00315. DXP_synth. [Tree]
InterPro	IPR005477. Dxylulose-5-P_synthase. IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KO	K01662.
Pfam	PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. [Graphical view]
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
SUPFAM	SSF52922. Transketo_C_like. 1 hit.
TIGRFAMs	TIGR00204. Dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. 1 hit. PS00802. TRANSKETOLASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS_CHLT2

Accession

Primary (citable) accession number: B0B7P9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	February 26, 2008
Last modified:	January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program