B0B7L3 (RNC_CHLT2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease 3
EC=3.1.26.3

Alternative name(s):
Ribonuclease III
Short name=RNase III

Gene names

Name:	rnc
Ordered Locus Names:	CTL0549

Organism

Chlamydia trachomatis (strain L2/434/Bu / ATCC VR-902B) [Complete proteome] [HAMAP]

Taxonomic identifier

471472 [NCBI]

Taxonomic lineage

Bacteria › Chlamydiae › Chlamydiales › Chlamydiaceae › Chlamydia

Protein attributes

Sequence length	231 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs By similarity. HAMAP MF_00104
Catalytic activity	Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP MF_00104
Subcellular location	Cytoplasm By similarity HAMAP MF_00104.
Sequence similarities	Contains 1 DRBM (double-stranded RNA-binding) domain. Contains 1 RNase III domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	RNA-binding
Molecular function	Endonuclease Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	RNA processing Inferred from electronic annotation. Source: InterPro rRNA catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	double-stranded RNA binding Inferred from electronic annotation. Source: InterPro ribonuclease III activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 231	231	Ribonuclease 3 HAMAP MF_00104		PRO_1000094099
Regions
	Domain	7 – 135	129	RNase III
	Domain	160 – 229	70	DRBM

Sequences

	Sequence		Length	Mass (Da)
	B0B7L3-1 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: 9AC603E1DB831C6A	FASTA	231	25,595
	10 20 30 40 50 60 MQHTVDIQAI ESKLNFTFSH PRLLITALTH PSYRNEFPSA EEDSERLEFL GDAVLGLVVT 70 80 90 100 110 120 EHLFLLFPAL NEGLLSTTRA ALVNAEACFE YTQKLSLGEH LLIGRGEKMQ SHRGKISAYA 130 140 150 160 170 180 NLFEAILGAV YLDGGLSPAR QIIVPLLPDK ESILPLMLVN PKNRLQQFTQ QTLKVLPSYK 190 200 210 220 230 ALPWKSEDGS PGYHVQVFVN GDLWGEGFAG SKKEAEKLAA KQALSTHDNK N

References

[1]

"Chlamydia trachomatis: genome sequence analysis of lymphogranuloma venereum isolates." Thomson N.R., Holden M.T.G., Carder C., Lennard N., Lockey S.J., Marsh P., Skipp P., O'Connor C.D., Goodhead I., Norbertzcak H., Harris B., Ormond D., Rance R., Quail M.A., Parkhill J., Stephens R.S., Clarke I.N. Genome Res. 18:161-171(2008) [PubMed: 18032721] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM884176 Genomic DNA. Translation: CAP03989.1.
RefSeq	YP_001654626.1.
3D structure databases
ProteinModelPortal	B0B7L3.
SMR	B0B7L3. Positions 6-226.
ModBase	Search...
Genome annotation databases
GeneID	5858279.
GenomeReviews	Gene locus CTL0549 in contig AM884176_GR.
KEGG	ctb:CTL0549.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG744556.
OMA	THASART.
ProtClustDB	PRK00102.
Enzyme and pathway databases
BioCyc	CTRA471472:CTL0549-MONOMER.
Family and domain databases
HAMAP	MF_00104. RNase_III. [Tree]
InterPro	IPR001159. Ds-RNA-bd. IPR014720. dsRNA-bd-like. IPR000999. RNase_III. IPR011907. RNase_III_bac. [Graphical view]
Gene3D	G3DSA:3.30.160.20. dsRNA-bd-like. 1 hit. G3DSA:1.10.1520.10. RNase_III. 1 hit.
Pfam	PF00035. dsrm. 1 hit. PF00636. Ribonuclease_3. 1 hit. [Graphical view]
SMART	SM00358. DSRM. 1 hit. SM00535. RIBOc. 1 hit. [Graphical view]
SUPFAM	SSF69065. RNase_III. 1 hit.
TIGRFAMs	TIGR02191. RNaseIII. 1 hit.
PROSITE	PS50137. DS_RBD. 1 hit. PS00517. RNASE_3_1. 1 hit. PS50142. RNASE_3_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RNC_CHLT2

Accession

Primary (citable) accession number: B0B7L3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	February 26, 2008
Last modified:	August 10, 2010
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)