A9ZZC5 (A9ZZC5_YERPE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Glyoxylate/hydroxypyruvate reductase B HAMAP MF_01667
EC=1.1.1.79 HAMAP MF_01667
EC=1.1.1.81 HAMAP MF_01667

Gene names

Name:	tkrA EMBL EDR39165.1
Synonyms:	ghrB HAMAP MF_01667
ORF Names:	YpF1991016_2316 EMBL EDR39165.1

Organism

Yersinia pestis biovar Orientalis str. F1991016 EMBL EDR39165.1

Taxonomic identifier

404214 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively By similarity. HAMAP MF_01667
Catalytic activity	D-glycerate + NAD(P)+ = hydroxypyruvate + NAD(P)H. SAAS SAAS023756 HAMAP MF_01667 Glycolate + NADP+ = glyoxylate + NADPH. HAMAP MF_01667 SAAS SAAS023756
Subunit structure	Homodimer By similarity. HAMAP MF_01667 SAAS SAAS023756
Subcellular location	Cytoplasm By similarity SAAS SAAS023756 HAMAP MF_01667.
Sequence similarities	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily. HAMAP MF_01667

Ontologies

Keywords
Cellular component	Cytoplasm SAAS SAAS023756 HAMAP MF_01667
Ligand	NAD SAAS SAAS023756 HAMAP MF_01667 NADP SAAS SAAS023756 HAMAP MF_01667
Molecular function	Oxidoreductase SAAS SAAS023756 HAMAP MF_01667 EMBL EDR39165.1
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro glyoxylate reductase (NADP) activity Inferred from electronic annotation. Source: HAMAP hydroxypyruvate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	237	1	By similarity HAMAP MF_01667
	Active site	266	1	By similarity HAMAP MF_01667
	Active site	285	1	Proton donor By similarity HAMAP MF_01667

Sequences

	Sequence		Length	Mass (Da)
	A9ZZC5 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: 935B405A48250AE2	FASTA	326	35,465
	10 20 30 40 50 60 MKPSIVLYKS IPTDLHQRLA QHFTVNSFDG LTPDNQPELL AALQQAEGLI GSGGKIDQDF 70 80 90 100 110 120 LQLAPNLRAA STISVGYDNF DVEALSQRGI ALMHTPTVLT ETVADTMMAL MLSTARRVVE 130 140 150 160 170 180 LAERVKAGEW QESIGDDWFG VDVHHKTIGI LGMGRIGMAL AQRAHFGFSM PVLYTSRRPH 190 200 210 220 230 240 EAAEQRFGAR HCSLDTLLAE ADFLCITLPM TEQTYHMIGR EQLAKMKSSA ILINAGRGPV 250 260 270 280 290 300 VDEQALIAAL QDGTIHAAGL DVFEQEPLPV DSPLLTLRNV VAVPHIGSAT HETRYNMAAC 310 320 AVDNLINALT GTVKENCVNP QVLITH

References

[1]	"Draft genome sequences of Yersinia pestis isolates from natural foci of endemic plague in China." Eppinger M., Guo Z., Sebastian Y., Song Y., Lindler L.E., Yang R., Ravel J. J. Bacteriol. 191:7628-7629(2009) [PubMed: 19820101] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: F1991016 EMBL EDR39165.1.
[2]	Payne S.H., Sutton G.G. Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: F1991016 EMBL EDR39165.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	ABAT01000007 Genomic DNA. Translation: EDR39165.1.
3D structure databases
ProteinModelPortal	A9ZZC5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
PATRIC	29640896. VBIYerPes113109_2229.
Phylogenomic databases
OMA	HALTEKK.
Family and domain databases
HAMAP	MF_01667. 2_Hacid_dh_C_GhrB. [Tree]
InterPro	IPR006139. D-isomer_2_OHA_DH_cat_dom. IPR006140. D-isomer_2_OHA_DH_NAD-bd. IPR023756. Glyo/OHPyrv_Rdtase_B. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 2 hits.
Pfam	PF00389. 2-Hacid_dh. 1 hit. PF02826. 2-Hacid_dh_C. 1 hit. [Graphical view]
PROSITE	PS00065. D_2_HYDROXYACID_DH_1. 1 hit. PS00671. D_2_HYDROXYACID_DH_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A9ZZC5_YERPE

Accession

Primary (citable) accession number: A9ZZC5

Entry history

Integrated into UniProtKB/TrEMBL:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)