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A9ZGX0 (A9ZGX0_COXBU) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
L-threonine 3-dehydrogenase HAMAP MF_00627
EC=1.1.1.103 HAMAP MF_00627
Gene names
Name:tdh HAMAP MF_00627 EMBL EDR36509.1
ORF Names:COXBURSA334_1972 EMBL EDR36509.1
OrganismCoxiella burnetii RSA 334 EMBL EDR36509.1
Taxonomic identifier360117 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH. HAMAP MF_00627 SAAS SAAS002328

Cofactor

Binds 2 zinc ions per subunit By similarity. HAMAP MF_00627 SAAS SAAS002328

Pathway

Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2. HAMAP MF_00627 SAAS SAAS002328

Subunit structure

Homotetramer By similarity. HAMAP MF_00627

Subcellular location

Cytoplasm By similarity HAMAP MF_00627 SAAS SAAS002328.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family. HAMAP MF_00627 RuleBase RU000468

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding381Zinc 1; catalytic By similarity HAMAP MF_00627
Metal binding631Zinc 1; catalytic By similarity HAMAP MF_00627
Metal binding931Zinc 2 By similarity HAMAP MF_00627
Metal binding961Zinc 2 By similarity HAMAP MF_00627
Metal binding991Zinc 2 By similarity HAMAP MF_00627
Metal binding1071Zinc 2 By similarity HAMAP MF_00627
Metal binding1481Zinc 1; catalytic By similarity HAMAP MF_00627

Sequences

Sequence LengthMass (Da)Tools
A9ZGX0 [UniParc].

Last modified February 26, 2008. Version 1.
Checksum: 71007C99C50DF6B6

FASTA34237,194
        10         20         30         40         50         60 
MKVLSKLKPA PGLWLHKAPT PKPGRDEVLI KIKKTAICGT DLHIYKWDEW AQKTIPVPMH 

        70         80         90        100        110        120 
VGHEFVGEIV EVGEAASALA VGDRVSGEGH ITCGDCRNCR AGKRHLCRYT VGVGVNRPGA 

       130        140        150        160        170        180 
FAEYLVIPAK NAYKIPAKIS DDIAAILDPF GNAAHSALEF DLVGEDVLIT GAGPVGLMSA 

       190        200        210        220        230        240 
AIARHVGARH VVITDVNDYR LALAEKVGVT AAVNSTKTPL TETMKNLGMT EGFDVGLEMS 

       250        260        270        280        290        300 
GNAEAFRSML TVMNNGGKIA FLGIPPEPFA IDWNQVVFKS LLIKGIYGRR MFETWYKMTN 

       310        320        330        340 
LLLSGLDISP IITHEFPMKD FQQAFDVMLS GKTGKVILNW EQ

« Hide

References

[1]"Genome sequencing of phylogenetically and phenotypically diverse Coxiella burnetii isolates."
Seshadri R., Samuel J.E.
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: RSA 334 EMBL EDR36509.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AAYJ01000003 Genomic DNA. Translation: EDR36509.1.

3D structure databases

ProteinModelPortalA9ZGX0.
ModBaseSearch...

Proteomic databases

PRIDEA9ZGX0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

PATRIC27686422. VBICoxBur129292_0281.

Phylogenomic databases

OMAMMRSGMS.

Family and domain databases

HAMAPMF_00627. Thr_dehydrog.
[Tree]
InterProIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR004627. L-Threonine_3-DHase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMSSF50129. GroES_like. 1 hit.
TIGRFAMsTIGR00692. Tdh. 1 hit.
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA9ZGX0_COXBU
AccessionPrimary (citable) accession number: A9ZGX0
Entry history
Integrated into UniProtKB/TrEMBL: February 26, 2008
Last sequence update: February 26, 2008
Last modified: December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info