Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fer-1-like protein 4

Gene

FER1L4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Fer-1-like protein 4
Gene namesi
Name:FER1L4
Synonyms:C20orf124
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:15801. FER1L4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 1760CytoplasmicSequence analysisAdd BLAST1760
Transmembranei1761 – 1781HelicalSequence analysisAdd BLAST21
Topological domaini1782 – 1794ExtracellularSequence analysisAdd BLAST13

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi80307.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003464221 – 1794Fer-1-like protein 4Add BLAST1794

Proteomic databases

EPDiA9Z1Z3.
MaxQBiA9Z1Z3.
PRIDEiA9Z1Z3.

PTM databases

PhosphoSitePlusiA9Z1Z3.

Expressioni

Gene expression databases

CleanExiHS_FER1L4.

Structurei

3D structure databases

ProteinModelPortaliA9Z1Z3.
SMRiA9Z1Z3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 117C2 1PROSITE-ProRule annotationAdd BLAST105
Domaini176 – 298C2 2PROSITE-ProRule annotationAdd BLAST123
Domaini748 – 853C2 3PROSITE-ProRule annotationAdd BLAST106
Domaini1236 – 1334C2 4PROSITE-ProRule annotationAdd BLAST99
Domaini1479 – 1608C2 5PROSITE-ProRule annotationAdd BLAST130

Sequence similaritiesi

Belongs to the ferlin family.Curated
Contains 5 C2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG108221.
InParanoidiA9Z1Z3.
PhylomeDBiA9Z1Z3.

Family and domain databases

Gene3Di2.60.40.150. 7 hits.
InterProiIPR000008. C2_dom.
IPR030001. Fer1l4.
IPR012968. FerIin_dom.
IPR012561. Ferlin_B-domain.
IPR032362. Ferlin_C.
[Graphical view]
PANTHERiPTHR12546:SF36. PTHR12546:SF36. 5 hits.
PfamiPF00168. C2. 5 hits.
PF08150. FerB. 1 hit.
PF08151. FerI. 1 hit.
PF16165. Ferlin_C. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 5 hits.
SM01201. FerB. 1 hit.
SM01202. FerI. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 6 hits.
PROSITEiPS50004. C2. 5 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A9Z1Z3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFSPLKSRAR ALAHGDPFQV SRAQDFQVGV TVLEAQKLVG VNINPYVAVQ
60 70 80 90 100
VGGQRRVTAT QRGTSCPFYN EYFLFEFHDT RLRLQDLLLE ITAFHSQTLP
110 120 130 140 150
FMATRIGTFR MDLGIILDQP DGQFYQRWVP LHDPRDTRAG TKGFIKVTLS
160 170 180 190 200
VRARGDLPPP MLPPAPGHCS DIEKNLLLPR GVPAERPWAR LRVRLYRAEG
210 220 230 240 250
LPALRLGLLG SLVRALHDQR VLVEPYVRVS FLGQEGETSV SAEAAAPEWN
260 270 280 290 300
EQLSFVELFP PLTRSLRLQL RDDAPLVDAA LATHVPDLRR ISHPGRAAGF
310 320 330 340 350
NPTFGPAWVP LYGSPPGAGL RDSLQGLNEG VGQGIWFRGR LLLAVSMQVL
360 370 380 390 400
EGRAEPEPPQ AQQGSTLSRL TRKKKKKARR DQTPKAVPQH LDASPGAEGP
410 420 430 440 450
EIPRAMEVEV EELLPLPENV LAPCEDFLLF GVLFEATMID PTVASQPISF
460 470 480 490 500
EISIGRAGRL EEQLGRGSRA GEGTEGAAVE AQPLLGARPE EEKEEEELGT
510 520 530 540 550
HAQRPEPMDG SGPYFCLPLC HCKPCMHVWS CWEDHTWRLQ SSNCVRKVAE
560 570 580 590 600
RLDQGLQEVE RLQRKPGPGA CAQLKQALEV LVAGSRQFCH GAERRTMTRP
610 620 630 640 650
NALDRCRGKL LVHSLNLLAK QGLRLLRGLR RRNVQKKVAL AKKLLAKLRF
660 670 680 690 700
LAEEPQPPLP DVLVWMLSGQ RRVAWARIPA QDVLFSVVEE ERGRDCGKIQ
710 720 730 740 750
SLMLTAPGAA PGEVCAKLEL FLRLGLGKQA KACTSELPPD LLPEPSAGLP
760 770 780 790 800
SSLHRDDFSY FQLRAHLYQA RGVLAADDSG LSDPFARVLI STQCQTTRVL
810 820 830 840 850
EQTLSPLWDE LLVFEQLIVD GRREHLQEEP PLVIINVFDH NKFGPPVFLG
860 870 880 890 900
RALAAPRVKL MEDPYQRPEL QFFPLRKGPW AAGELIAAFQ LIELDYSGRL
910 920 930 940 950
EPSVPSEVEP QDLAPLVEPH SGRLSLPPNV CPVLREFRVE VLFWGLRGLG
960 970 980 990 1000
RVHLLEVEQP QVVLEVAGQG VESEVLASYR ESPNFTELVR HLTVDLPEQP
1010 1020 1030 1040 1050
YLQPPLSILV IERRAFGHTV LVGSHIVPHM LRFTFRGHED PPEEEGEMEE
1060 1070 1080 1090 1100
TGDMMPKGPQ GQKSLDPFLA EAGISRQLLK PPLKKLPLGG LLNQGPGLEE
1110 1120 1130 1140 1150
DIPDPEELDW GSKYYASLQE LQGQHNFDED EMDDPGDSDG VNLISMVGEI
1160 1170 1180 1190 1200
QDQGEAEVKG TVSPKKAVAT LKIYNRSLKE EFNHFEDWLN VFPLYRGQGG
1210 1220 1230 1240 1250
QDGGGEEEGS GHLVGKFKGS FLIYPESEAV LFSEPQISRG IPQNRPIKLL
1260 1270 1280 1290 1300
VRVYVVKATN LAPADPNGKA DPYVVVSAGR ERQDTKERYI PKQLNPIFGE
1310 1320 1330 1340 1350
ILELSISLPA ETELTVAVFD HDLVGSDDLI GETHIDLENR FYSHHRANCG
1360 1370 1380 1390 1400
LASQYEVDGY NAWRDAFWPS QILAGLCQRC GLPAPEYRAG AVKVGSKVFL
1410 1420 1430 1440 1450
TPPETLPPGS SSPTVASGDP EEAQALLVLR RWQEMPGFGI QLVPEHVETR
1460 1470 1480 1490 1500
PLYHPHSPGL LQGSLHMWID IFPQDVPAPP PVDIKPRQPI SYELRVVIWN
1510 1520 1530 1540 1550
TEDVVLDDEN PLTGEMSSDI YVKSWVKGLE HDKQETDVHF NSLTGEGNFN
1560 1570 1580 1590 1600
WRFVFRFDYL PTEREVSVWR RSGPFALEEA EFRQPAVLVL QVWDYDRISA
1610 1620 1630 1640 1650
NDFLGSLELQ LPDMVRGARG PELCSVQLAR NGAGPRCNLF RCRRLRGWWP
1660 1670 1680 1690 1700
VVKLKEAEDV EREAQEAQAG KKKRKQRRRK GRPEDLEFTD MGGNVYILTG
1710 1720 1730 1740 1750
KVEAEFELLT VEEAEKRPVG KGRKQPEPLE KPSRPKTSFN WFVNPLKTFV
1760 1770 1780 1790
FFIWRRYWRT LVLLLLVLLT VFLLLVFYTI PGQISQVIFR PLHK
Length:1,794
Mass (Da):200,980
Last modified:February 5, 2008 - v1
Checksum:iA057803847E74EC2
GO
Isoform 2 (identifier: A9Z1Z3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1466: Missing.

Note: No experimental confirmation available.
Show »
Length:328
Mass (Da):38,388
Checksum:iB9090FF0D858C06A
GO
Isoform 3 (identifier: A9Z1Z3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1358-1367: DGYNAWRDAF → WVQQGPQEPF
     1368-1794: Missing.

Show »
Length:1,367
Mass (Da):151,987
Checksum:i49144DEFA13010BA
GO
Isoform 4 (identifier: A9Z1Z3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     92-92: T → TVSGVGVTSVLQRRGDEKAAGLTPPSPK
     121-127: DGQFYQR → GMESSPY
     128-1794: Missing.

Note: No experimental confirmation available.
Show »
Length:154
Mass (Da):17,030
Checksum:i1AA8CBBE0A16C9E2
GO

Sequence cautioni

The sequence BAB14597 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1320D → E in BAB14597 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0458931179K → E.Corresponds to variant rs1557202dbSNPEnsembl.1
Natural variantiVAR_0458941183N → S.Corresponds to variant rs11698021dbSNPEnsembl.1
Natural variantiVAR_0458951318V → I.Corresponds to variant rs2277862dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0349841 – 1466Missing in isoform 2. 1 PublicationAdd BLAST1466
Alternative sequenceiVSP_03498592T → TVSGVGVTSVLQRRGDEKAA GLTPPSPK in isoform 4. 1 Publication1
Alternative sequenceiVSP_034986121 – 127DGQFYQR → GMESSPY in isoform 4. 1 Publication7
Alternative sequenceiVSP_034987128 – 1794Missing in isoform 4. 1 PublicationAdd BLAST1667
Alternative sequenceiVSP_0349881358 – 1367DGYNAWRDAF → WVQQGPQEPF in isoform 3. 1 Publication10
Alternative sequenceiVSP_0349891368 – 1794Missing in isoform 3. 1 PublicationAdd BLAST427

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023521 mRNA. Translation: BAB14597.1. Different initiation.
AK026266 mRNA. Translation: BAB15420.1.
AF218012 mRNA. Translation: AAG17254.1.
AF218030 mRNA. Translation: AAG17272.1.
AL121586, AL109827, AL389875 Genomic DNA. Translation: CAB89410.2.
AL109827, AL121586, AL389875 Genomic DNA. Translation: CAI20117.2.
BC029951 mRNA. No translation available.
UniGeneiHs.72222.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023521 mRNA. Translation: BAB14597.1. Different initiation.
AK026266 mRNA. Translation: BAB15420.1.
AF218012 mRNA. Translation: AAG17254.1.
AF218030 mRNA. Translation: AAG17272.1.
AL121586, AL109827, AL389875 Genomic DNA. Translation: CAB89410.2.
AL109827, AL121586, AL389875 Genomic DNA. Translation: CAI20117.2.
BC029951 mRNA. No translation available.
UniGeneiHs.72222.

3D structure databases

ProteinModelPortaliA9Z1Z3.
SMRiA9Z1Z3.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSitePlusiA9Z1Z3.

Proteomic databases

EPDiA9Z1Z3.
MaxQBiA9Z1Z3.
PRIDEiA9Z1Z3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi80307.
GeneCardsiFER1L4.
HGNCiHGNC:15801. FER1L4.
neXtProtiNX_A9Z1Z3.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG108221.
InParanoidiA9Z1Z3.
PhylomeDBiA9Z1Z3.

Miscellaneous databases

ChiTaRSiFER1L4. human.
PROiA9Z1Z3.

Gene expression databases

CleanExiHS_FER1L4.

Family and domain databases

Gene3Di2.60.40.150. 7 hits.
InterProiIPR000008. C2_dom.
IPR030001. Fer1l4.
IPR012968. FerIin_dom.
IPR012561. Ferlin_B-domain.
IPR032362. Ferlin_C.
[Graphical view]
PANTHERiPTHR12546:SF36. PTHR12546:SF36. 5 hits.
PfamiPF00168. C2. 5 hits.
PF08150. FerB. 1 hit.
PF08151. FerI. 1 hit.
PF16165. Ferlin_C. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 5 hits.
SM01201. FerB. 1 hit.
SM01202. FerI. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 6 hits.
PROSITEiPS50004. C2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFR1L4_HUMAN
AccessioniPrimary (citable) accession number: A9Z1Z3
Secondary accession number(s): Q9GZQ9, Q9H646, Q9H8L7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: February 5, 2008
Last modified: November 2, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.