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A9YWS9

- A9YWS9_CAVPO

UniProt

A9YWS9 - A9YWS9_CAVPO

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Protein
Submitted name:

Alpha-enolase

Gene

Eno1

Organism
Cavia porcellus (Guinea pig)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei158 – 1581SubstrateUniRule annotation
Binding sitei167 – 1671SubstrateUniRule annotation
Active sitei210 – 2101Proton donorUniRule annotation
Binding sitei293 – 2931SubstrateUniRule annotation
Binding sitei318 – 3181SubstrateUniRule annotation
Active sitei343 – 3431Proton acceptorUniRule annotation
Binding sitei394 – 3941SubstrateUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: InterPro
  2. phosphopyruvate hydratase activity Source: InterPro
  3. poly(A) RNA binding Source: Ensembl

GO - Biological processi

  1. glycolytic process Source: InterPro
  2. negative regulation of cell growth Source: Ensembl
  3. negative regulation of transcription, DNA-templated Source: Ensembl
  4. response to virus Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha-enolaseImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:Eno1Imported
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
ProteomesiUP000005447: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
  3. membrane Source: Ensembl
  4. phosphopyruvate hydratase complex Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000005241.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni370 – 3734Substrate bindingUniRule annotation

Phylogenomic databases

eggNOGiCOG0148.
GeneTreeiENSGT00550000074560.
HOGENOMiHOG000072174.
HOVERGENiHBG000067.
OMAiVSEKSCN.
OrthoDBiEOG776SQ1.
TreeFamiTF300391.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
HAMAPiMF_00318. Enolase.
InterProiIPR000941. Enolase.
IPR020810. Enolase_C.
IPR029065. Enolase_C-like.
IPR020809. Enolase_CS.
IPR020811. Enolase_N.
IPR029017. Enolase_N_like.
[Graphical view]
PANTHERiPTHR11902. PTHR11902. 1 hit.
PfamiPF00113. Enolase_C. 1 hit.
PF03952. Enolase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001400. Enolase. 1 hit.
PRINTSiPR00148. ENOLASE.
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
TIGRFAMsiTIGR01060. eno. 1 hit.
PROSITEiPS00164. ENOLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9YWS9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSILKVHARE IFDSRGNPTV EVDLYTAKGL FRAAVPSGAS TGIYEALELR
60 70 80 90 100
DNDKTRYMGK GVSKAVEHIN NTIAPALVSK KLNVVEQEKI DKLMIEMDGT
110 120 130 140 150
ENKSKFGANA ILGVSLAVCK AGAVEKGVPL YRHIADLAGN AEVILPVPAF
160 170 180 190 200
NVINGGSHAG NKLAMQEFMI LPVGADSFKE AMRIGAEVYH NLKNVIKEKY
210 220 230 240 250
GKDATNVGDE GGFAPNILEN KEALELLKNA IGKAGYTDKV VIGMDVAASE
260 270 280 290 300
FFRSGKYDLD FKSPDDSSRY ISPDQLGDLY KSFIKDYPVV SIEDPFDQDD
310 320 330 340 350
WDAWQKFTAS VGIQVVGDDL TVTNPKRIAK AVNEKACNCL LLKVNQIGSV
360 370 380 390 400
TESLQACKLA HSNGWGVMVS HRSGETEDTF IADLVVGLST GQIKTGAPCR
410 420 430
SERLAKYNQL LRIEEELGSK AKFAGRNFRN PLAK
Length:434
Mass (Da):47,194
Last modified:February 5, 2008 - v1
Checksum:iC4B7B9E0095ADB1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAKN02028899 Genomic DNA. No translation available.
EU306867 mRNA. Translation: ABY21425.1.
RefSeqiNP_001166544.1. NM_001173073.1.
XP_005004262.1. XM_005004205.1.
XP_005004263.1. XM_005004206.1.

Genome annotation databases

EnsembliENSCPOT00000005874; ENSCPOP00000005241; ENSCPOG00000005812.
GeneIDi100306968.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAKN02028899 Genomic DNA. No translation available.
EU306867 mRNA. Translation: ABY21425.1 .
RefSeqi NP_001166544.1. NM_001173073.1.
XP_005004262.1. XM_005004205.1.
XP_005004263.1. XM_005004206.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10141.ENSCPOP00000005241.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCPOT00000005874 ; ENSCPOP00000005241 ; ENSCPOG00000005812 .
GeneIDi 100306968.

Organism-specific databases

CTDi 2023.

Phylogenomic databases

eggNOGi COG0148.
GeneTreei ENSGT00550000074560.
HOGENOMi HOG000072174.
HOVERGENi HBG000067.
OMAi VSEKSCN.
OrthoDBi EOG776SQ1.
TreeFami TF300391.

Family and domain databases

Gene3Di 3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
HAMAPi MF_00318. Enolase.
InterProi IPR000941. Enolase.
IPR020810. Enolase_C.
IPR029065. Enolase_C-like.
IPR020809. Enolase_CS.
IPR020811. Enolase_N.
IPR029017. Enolase_N_like.
[Graphical view ]
PANTHERi PTHR11902. PTHR11902. 1 hit.
Pfami PF00113. Enolase_C. 1 hit.
PF03952. Enolase_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF001400. Enolase. 1 hit.
PRINTSi PR00148. ENOLASE.
SUPFAMi SSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
TIGRFAMsi TIGR01060. eno. 1 hit.
PROSITEi PS00164. ENOLASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expressed sequence tag analysis of guinea pig (Cavia porcellus) eye tissues for NEIBank."
    Simpanya M.F., Wistow G., Gao J., David L.L., Giblin F.J., Mitton K.P.
    Mol. Vis. 14:2413-2427(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: LensImported.
  2. "A high-resolution map of human evolutionary constraint using 29 mammals."
    Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.
    , Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.
    Nature 478:476-482(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2NImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: 2NImported.

Entry informationi

Entry nameiA9YWS9_CAVPO
AccessioniPrimary (citable) accession number: A9YWS9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 26, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3