A9YLN4 (A9YLN4_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Tyrosine-protein kinase receptor RuleBase RU000312
EC=2.7.10.1 RuleBase RU000312

Gene names

Name:	CD74/ROS fusion EMBL ABX59671.1
Synonyms:	CD74-ROS1_C6;R34 EMBL BAM95198.1

Organism

Homo sapiens (Human) EMBL ABX59671.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	703 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. RuleBase RU000312 SAAS SAAS008266
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. RuleBase RU000312 Contains 1 protein kinase domain. SAAS SAAS008266

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane RuleBase RU000312
Ligand	ATP-binding SAAS SAAS008266 Nucleotide-binding
Molecular function	Kinase Receptor RuleBase RU000312 Transferase Tyrosine-protein kinase SAAS SAAS008266
PTM	Phosphoprotein RuleBase RU000312 SAAS SAAS002011
Gene Ontology (GO)
Biological_process	antigen processing and presentation Inferred from electronic annotation. Source: InterPro immune response Inferred from electronic annotation. Source: InterPro intracellular protein transport Inferred from electronic annotation. Source: InterPro transmembrane receptor protein tyrosine kinase signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW transmembrane receptor protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A9YLN4 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: BC2A10469BBE6862	FASTA	703	79,539
	10 20 30 40 50 60 MHRRRSRSCR EDQKPVMDDQ RDLISNNEQL PMLGRRPGAP ESKCSRGALY TGFSILVTLL 70 80 90 100 110 120 LAGQATTAYF LYQQQGRLDK LTVTSQNLQL ENLRMKLPKP PKPVSKMRMA TPLLMQALPM 130 140 150 160 170 180 GALPQGPMQN ATKYGNMTED HVMHLLQNAD PLKVYPPLKG SFPENLRHLK NTMETIDWKV 190 200 210 220 230 240 FESWMHHWLL FEMSRHSLEQ KPTDAPPKDD FWIPETSFIL TIIVGIFLVV TIPLTFVWHR 250 260 270 280 290 300 RLKNQKSAKE GVTVLINEDK ELAELRGLAA GVGLANACYA IHTLPTQEEI ENLPAFPREK 310 320 330 340 350 360 LTLRLLLGSG AFGEVYEGTA VDILGVGSGE IKVAVKTLKK GSTDQEKIEF LKEAHLMSKF 370 380 390 400 410 420 NHPNILKQLG VCLLNEPQYI ILELMEGGDL LTYLRKARMA TFYGPLLTLV DLVDLCVDIS 430 440 450 460 470 480 KGCVYLERMH FIHRDLAARN CLVSVKDYTS PRIVKIGDFG LARDIYKNDY YRKRGEGLLP 490 500 510 520 530 540 VRWMAPESLM DGIFTTQSDV WSFGILIWEI LTLGHQPYPA HSNLDVLNYV QTGGRLEPPR 550 560 570 580 590 600 NCPDDLWNLM TQCWAQEPDQ RPTFHRIQDQ LQLFRNFFLN SIYKSRDEAN NSGVINESFE 610 620 630 640 650 660 GEDGDVICLN SDDIMPVALM ETKNREGLNY MVLATECGQG EEKSEGPLGS QESESCGLRK 670 680 690 700 EEKEPHADKD FCQEKQVAYC PSGKPEGLNY ACLTHSGYGD GSD

References

[1]	"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. , Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J. Cell 131:1190-1203(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"RET, ROS1 and ALK fusions in lung cancer." Takeuchi K., Soda M., Togashi Y., Suzuki R., Sakata S., Hatano S., Asaka R., Hamanaka W., Ninomiya H., Uehara H., Lim Choi Y., Satoh Y., Okumura S., Nakagawa K., Mano H., Ishikawa Y. Nat. Med. 18:378-381(2012) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Lung EMBL BAM95198.1.
[3]	Dobashi A., Takeuchi K., Togashi Y., Sakata S., Hatano S., Asaka R. Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Lung EMBL BAM95198.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EU236945 mRNA. Translation: ABX59671.1. AB795245 mRNA. Translation: BAM95198.1.
3D structure databases
ProteinModelPortal	A9YLN4.
SMR	A9YLN4. Positions 134-208.
ModBase	Search...
Protein-protein interaction databases
STRING	A9YLN4.
Proteomic databases
PRIDE	A9YLN4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.10.870.10. 1 hit.
InterPro	IPR011009. Kinase-like_dom. IPR015386. MHC_II-assoc_invar/CLIP_MHC-bd. IPR022339. MHC_II-assoc_invar_chain. IPR011988. MHC_II-assoc_invariant_trimer. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. IPR002011. Tyr_kinase_rcpt_2_CS. [Graphical view]
Pfam	PF09307. MHC2-interact. 1 hit. PF08831. MHCassoc_trimer. 1 hit. PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PRINTS	PR01990. CD74ANTIGEN. PR00109. TYRKINASE.
SMART	SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit. SSF48305. MHC_II-assoc_invariant_trimer. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS00239. RECEPTOR_TYR_KIN_II. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	A9YLN4.
NextBio	35465422.

Entry information

Entry name

A9YLN4_HUMAN

Accession

Primary (citable) accession number: A9YLN4

Entry history

Integrated into UniProtKB/TrEMBL:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	May 1, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.