A9YLN4 (A9YLN4_HUMAN) Unreviewed, UniProtKB/TrEMBL
Last modified
May 29, 2013.
Version 43.
History...
Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order
Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize orderNames and origin
| Protein names | Recommended name: Tyrosine-protein kinase receptor RuleBase RU000312 EC=2.7.10.1 RuleBase RU000312 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) EMBL ABX59671.1 | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 703 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Catalytic activity | ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SAAS SAAS002011 RuleBase RU000312 |
| Sequence similarities | Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. RuleBase RU000312 Contains 1 protein kinase domain. SAAS SAAS002011 |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Transmembrane RuleBase RU000312 |
| Ligand | ATP-binding SAAS SAAS002011 Nucleotide-binding |
| Molecular function | Kinase Receptor RuleBase RU000312 Transferase Tyrosine-protein kinase SAAS SAAS002011 |
| PTM | Phosphoprotein SAAS SAAS002011 RuleBase RU000312 |
| Gene Ontology (GO) | |
| Biological_process | antigen processing and presentation Inferred from electronic annotation. Source: InterPro immune responseInferred from electronic annotation. Source: InterPro intracellular protein transportInferred from electronic annotation. Source: InterPro transmembrane receptor protein tyrosine kinase signaling pathwayInferred from electronic annotation. Source: InterPro |
| Cellular_component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular_function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW transmembrane receptor protein tyrosine kinase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequences
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References
| [1] | "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. Comb M.J.Cell 131:1190-1203(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. |
| [2] | "RET, ROS1 and ALK fusions in lung cancer." Takeuchi K., Soda M., Togashi Y., Suzuki R., Sakata S., Hatano S., Asaka R., Hamanaka W., Ninomiya H., Uehara H., Lim Choi Y., Satoh Y., Okumura S., Nakagawa K., Mano H., Ishikawa Y. Nat. Med. 18:378-381(2012) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Lung EMBL BAM95198.1. |
| [3] | Dobashi A., Takeuchi K., Togashi Y., Sakata S., Hatano S., Asaka R. Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Lung EMBL BAM95198.1. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | EU236945 mRNA. Translation: ABX59671.1. AB795245 mRNA. Translation: BAM95198.1. |
3D structure databases | |
| ProteinModelPortal | A9YLN4. |
| SMR | A9YLN4. Positions 134-208. |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | A9YLN4. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Family and domain databases | |
| Gene3D | 1.10.870.10. 1 hit. |
| InterPro | IPR011009. Kinase-like_dom. IPR015386. MHC_II-assoc_invar/CLIP_MHC-bd. IPR022339. MHC_II-assoc_invar_chain. IPR011988. MHC_II-assoc_invariant_trimer. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. IPR002011. Tyr_kinase_rcpt_2_CS. [Graphical view] |
| Pfam | PF09307. MHC2-interact. 1 hit. PF08831. MHCassoc_trimer. 1 hit. PF07714. Pkinase_Tyr. 1 hit. [Graphical view] |
| PRINTS | PR01990. CD74ANTIGEN. PR00109. TYRKINASE. |
| SMART | SM00219. TyrKc. 1 hit. [Graphical view] |
| SUPFAM | SSF56112. Kinase_like. 1 hit. SSF48305. MHC_II-assoc_invariant_trimer. 1 hit. |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS00239. RECEPTOR_TYR_KIN_II. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| BindingDB | A9YLN4. |
| NextBio | 35465422. |
Entry information
| Entry name | A9YLN4_HUMAN | ||||||||
| Accession | Primary (citable) accession number: A9YLN4 | ||||||||
| Entry history |
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| Entry status | Unreviewed (UniProtKB/TrEMBL) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||

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