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Protein

Aquaporin-3

Gene

AQP3

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-3
Alternative name(s):
Aquaglyceroporin-3
Gene namesi
Name:AQP3
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei29 – 4921HelicalSequence analysisAdd
BLAST
Topological domaini50 – 534ExtracellularSequence analysis
Transmembranei54 – 7421HelicalSequence analysisAdd
BLAST
Topological domaini75 – 10935CytoplasmicSequence analysisAdd
BLAST
Transmembranei110 – 13021HelicalSequence analysisAdd
BLAST
Topological domaini131 – 15727ExtracellularSequence analysisAdd
BLAST
Transmembranei158 – 17821HelicalSequence analysisAdd
BLAST
Topological domaini179 – 18810CytoplasmicSequence analysis
Transmembranei189 – 20921HelicalSequence analysisAdd
BLAST
Topological domaini210 – 24435ExtracellularSequence analysisAdd
BLAST
Transmembranei245 – 26521HelicalSequence analysisAdd
BLAST
Topological domaini266 – 29025CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Aquaporin-3PRO_0000394026Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA9Y006.

Expressioni

Tissue specificityi

Highly expressed in stomach and spleen, with lower expression in kidney and lung.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011724.

Structurei

3D structure databases

ProteinModelPortaliA9Y006.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi83 – 853NPA 1By similarity
Motifi215 – 2173NPA 2By similarity

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0224. Eukaryota.
COG0580. LUCA.
HOGENOMiHOG000288287.
HOVERGENiHBG106057.
InParanoidiA9Y006.
KOiK09876.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023275. Aquaporin_3.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR02015. AQUAPORIN3.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9Y006-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRQKELVTR CGEMLHIRYR LLRQALAECL GTLILVMFGC GSVAQVVLSR
60 70 80 90 100
GTHGGFLTIN LAFGFAVTLG ILVAGQVSGA HLNPAVTFAM CFLAREPWIK
110 120 130 140 150
LPVYTLAQTL GAFLGAGIIF GLYYDAIWAF ANNQLIVSGP NGTAGIFATY
160 170 180 190 200
PSGHLDMVNG FFDQFIGTAS LIVCVLAIVD PNNNPVPRGL EAFTVGLVVL
210 220 230 240 250
VIGTSMGFNS GYAVNPARDF GPRLFTAIAG WGSEVFTTGR HWWWVPIASP
260 270 280 290
LLGSIAGVFV YQLMIGCHLE PPPPSTDEEN VKLSQVKHKE
Length:290
Mass (Da):31,145
Last modified:February 5, 2008 - v1
Checksum:i12312C8A983F2D27
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti248 – 2481A → V in ABW06862 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU024115 Genomic DNA. Translation: ABW06528.1.
EU161094 mRNA. Translation: ABW06862.1.
RefSeqiNP_001103642.1. NM_001110172.1.
UniGeneiSsc.3832.

Genome annotation databases

GeneIDi100126235.
KEGGissc:100126235.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU024115 Genomic DNA. Translation: ABW06528.1.
EU161094 mRNA. Translation: ABW06862.1.
RefSeqiNP_001103642.1. NM_001110172.1.
UniGeneiSsc.3832.

3D structure databases

ProteinModelPortaliA9Y006.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011724.

Proteomic databases

PaxDbiA9Y006.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100126235.
KEGGissc:100126235.

Organism-specific databases

CTDi360.

Phylogenomic databases

eggNOGiKOG0224. Eukaryota.
COG0580. LUCA.
HOGENOMiHOG000288287.
HOVERGENiHBG106057.
InParanoidiA9Y006.
KOiK09876.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023275. Aquaporin_3.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR02015. AQUAPORIN3.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular characterization, chromosomal and expression patterns of three aquaglyceroporins (AQP3, 7, 9) from pig."
    Li X., Lei T., Xia T., Chen X., Feng S., Chen H., Chen Z., Peng Y., Yang Z.
    Comp. Biochem. Physiol. 149B:468-476(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Molecular cloning and expression of porcine aquaporin 3."
    Zhang Z.-Q., Wang Y.-L., Yang G.-Y., Wang W.-J., Tai Y.-L., Han L.-Q.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiAQP3_PIG
AccessioniPrimary (citable) accession number: A9Y006
Secondary accession number(s): A8IF63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: February 5, 2008
Last modified: June 8, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.