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A9XE60

- KBX11_MESEU

UniProt

A9XE60 - KBX11_MESEU

Protein

Potassium channel toxin MeuTXK-beta-1

Gene
N/A
Organism
Mesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Has a low affinity binding to potassium channels of rat brain synaptosomes. Displays weak antibacterial activity against Stenotrophomonas sp. Strongly inhibits the development of the Plasmodium berghei ookinetes. Displays slight hemolytic effect on mouse erythrocytes. Induces cytolysis on Xenopus oocytes at high concentrations. Is not toxic on mice and on the insect Tenebrio molitor.1 Publication

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW
    2. hemolysis in other organism Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Ion channel impairing toxin, Potassium channel impairing toxin, Toxin

    Keywords - Biological processi

    Cytolysis, Hemolysis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel toxin MeuTXK-beta-1
    Short name:
    MeuTXKbeta1
    OrganismiMesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus)
    Taxonomic identifieri34648 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeMesobuthus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 19191 PublicationAdd
    BLAST
    Chaini20 – 9172Potassium channel toxin MeuTXK-beta-1PRO_0000394022Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi57 ↔ 78By similarity
    Disulfide bondi64 ↔ 83By similarity
    Disulfide bondi68 ↔ 85By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR029237. Long_scorpion_toxin.
    [Graphical view]
    PfamiPF14866. Toxin_38. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A9XE60-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQRNLVVLLF LGMVALSSCG FREKHFQRFV KYAVPESTLR TVLQTVVHKV   50
    GKTQFGCPAY QGYCDDHCQD IEKKEGFCHG FKCKCGIPMG F 91
    Length:91
    Mass (Da):10,338
    Last modified:February 5, 2008 - v1
    Checksum:iC2879665D440C682
    GO

    Mass spectrometryi

    Molecular mass is 8256.81 Da from positions 20 - 91. Determined by MALDI. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF190325 mRNA. Translation: ABP35519.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF190325 mRNA. Translation: ABP35519.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR029237. Long_scorpion_toxin.
    [Graphical view ]
    Pfami PF14866. Toxin_38. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "MeuTXKbeta1, a scorpion venom-derived two-domain potassium channel toxin-like peptide with cytolytic activity."
      Zhu S., Gao B., Aumelas A., Del Carmen Rodriguez M., Lanz-Mendoza H., Peigneur S., Diego-Garcia E., Martin-Eauclaire M.-F., Tytgat J., Possani L.D.
      Biochim. Biophys. Acta 1804:872-883(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-23, FUNCTION, MASS SPECTROMETRY.
      Tissue: Venom and Venom gland.

    Entry informationi

    Entry nameiKBX11_MESEU
    AccessioniPrimary (citable) accession number: A9XE60
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 18, 2010
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 17 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Scorpion potassium channel toxins
      Nomenclature of scorpion potassium channel toxins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3