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Protein

Potassium channel toxin MeuTXK-beta-1

Gene
N/A
Organism
Mesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has a low affinity binding to potassium channels of rat brain synaptosomes. Displays weak antibacterial activity against Stenotrophomonas sp. Strongly inhibits the development of the Plasmodium berghei ookinetes. Displays slight hemolytic effect on mouse erythrocytes. Induces cytolysis on Xenopus oocytes at high concentrations. Is not toxic on mice and on the insect Tenebrio molitor.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Ion channel impairing toxin, Potassium channel impairing toxin, Toxin

Keywords - Biological processi

Cytolysis, Hemolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin MeuTXK-beta-1
Short name:
MeuTXKbeta1
OrganismiMesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus)
Taxonomic identifieri34648 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeMesobuthus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 PublicationAdd
BLAST
Chaini20 – 9172Potassium channel toxin MeuTXK-beta-1PRO_0000394022Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi57 ↔ 78By similarity
Disulfide bondi64 ↔ 83By similarity
Disulfide bondi68 ↔ 85By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR029237. Long_scorpion_toxin.
[Graphical view]
PfamiPF14866. Toxin_38. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A9XE60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRNLVVLLF LGMVALSSCG FREKHFQRFV KYAVPESTLR TVLQTVVHKV
60 70 80 90
GKTQFGCPAY QGYCDDHCQD IEKKEGFCHG FKCKCGIPMG F
Length:91
Mass (Da):10,338
Last modified:February 5, 2008 - v1
Checksum:iC2879665D440C682
GO

Mass spectrometryi

Molecular mass is 8256.81 Da from positions 20 - 91. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF190325 mRNA. Translation: ABP35519.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF190325 mRNA. Translation: ABP35519.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR029237. Long_scorpion_toxin.
[Graphical view]
PfamiPF14866. Toxin_38. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "MeuTXKbeta1, a scorpion venom-derived two-domain potassium channel toxin-like peptide with cytolytic activity."
    Zhu S., Gao B., Aumelas A., Del Carmen Rodriguez M., Lanz-Mendoza H., Peigneur S., Diego-Garcia E., Martin-Eauclaire M.-F., Tytgat J., Possani L.D.
    Biochim. Biophys. Acta 1804:872-883(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-23, FUNCTION, MASS SPECTROMETRY.
    Tissue: Venom and Venom gland.

Entry informationi

Entry nameiKBX11_MESEU
AccessioniPrimary (citable) accession number: A9XE60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: February 5, 2008
Last modified: January 7, 2015
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.