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A9XE60 (KBX11_MESEU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel toxin MeuTXK-beta-1

Short name=MeuTXKbeta1
OrganismMesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus)
Taxonomic identifier34648 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeMesobuthus

Protein attributes

Sequence length91 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has a low affinity binding to potassium channels of rat brain synaptosomes. Displays weak antibacterial activity against Stenotrophomonas sp. Strongly inhibits the development of the Plasmodium berghei ookinetes. Displays slight hemolytic effect on mouse erythrocytes. Induces cytolysis on Xenopus oocytes at high concentrations. Is not toxic on mice and on the insect Tenebrio molitor. Ref.1

Subcellular location

Secreted.

Tissue specificity

Expressed by the venom gland.

Sequence similarities

Belongs to the long chain scorpion toxin family. Class 1 subfamily.

Mass spectrometry

Molecular mass is 8256.81 Da from positions 20 - 91. Determined by MALDI. Ref.1

Ontologies

Keywords
   Biological processCytolysis
Hemolysis
   Cellular componentSecreted
   DomainSignal
   Molecular functionAntibiotic
Antimicrobial
Ion channel impairing toxin
Potassium channel impairing toxin
Toxin
   PTMDisulfide bond
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processdefense response to bacterium

Inferred from electronic annotation. Source: UniProtKB-KW

hemolysis in other organism

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Ref.1
Chain20 – 9172Potassium channel toxin MeuTXK-beta-1
PRO_0000394022

Amino acid modifications

Disulfide bond57 ↔ 78 By similarity
Disulfide bond64 ↔ 83 By similarity
Disulfide bond68 ↔ 85 By similarity

Sequences

Sequence LengthMass (Da)Tools
A9XE60 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: C2879665D440C682

FASTA9110,338
        10         20         30         40         50         60 
MQRNLVVLLF LGMVALSSCG FREKHFQRFV KYAVPESTLR TVLQTVVHKV GKTQFGCPAY 

        70         80         90 
QGYCDDHCQD IEKKEGFCHG FKCKCGIPMG F 

« Hide

References

[1]"MeuTXKbeta1, a scorpion venom-derived two-domain potassium channel toxin-like peptide with cytolytic activity."
Zhu S., Gao B., Aumelas A., Del Carmen Rodriguez M., Lanz-Mendoza H., Peigneur S., Diego-Garcia E., Martin-Eauclaire M.-F., Tytgat J., Possani L.D.
Biochim. Biophys. Acta 1804:872-883(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-23, FUNCTION, MASS SPECTROMETRY.
Tissue: Venom and Venom gland.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EF190325 mRNA. Translation: ABP35519.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameKBX11_MESEU
AccessionPrimary (citable) accession number: A9XE60
Entry history
Integrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: February 5, 2008
Last modified: February 19, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries