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A9WZ23

- GCSP_BRUSI

UniProt

A9WZ23 - GCSP_BRUSI

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, BSUIS_B0715
Organism
Brucella suis (strain ATCC 23445 / NCTC 10510)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBSUI470137:GJIC-2721-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:BSUIS_B0715
OrganismiBrucella suis (strain ATCC 23445 / NCTC 10510)
Taxonomic identifieri470137 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000008545: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 932932Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000083204Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei685 – 6851N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi470137.BSUIS_B0715.

Structurei

3D structure databases

ProteinModelPortaliA9WZ23.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFHQYRSE.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A9WZ23-1 [UniParc]FASTAAdd to Basket

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MTEFLPFVAR HIGPRHEDER AMLAALGLPS METLITQAVP ASIRLNRALN    50
LPAALSEADA LAELGTIMGR NVVKKSFIGA GYHGVHTPPV IQRNLFENPA 100
WYTAYTPYQS EISQGRLELL FHFQTLVAEL TGLPVACASL LDEATAVAEA 150
IGVACRHHRD KRSRILLAGE LHPQTVDVVN TRAEPLGWEI ATGSDVDDNT 200
AAIVVPWPDT RGVYGDFAKV IADAKAKGAL VIAVADPLAL TIMEAPARWG 250
ADMAVGSMQR YGVPMGFGGP HAAYLAVSEA LTRIIPGRIV GQSVDAHGRA 300
AYRLALQTRE QHIRRDKATS NICTAQALLA NMAAAFAIWH GPAGLQAIAT 350
RVAALAARFA AALKAAGVEI AGESLFDTVT AKVPGKAAAI AAEADKGGRL 400
IRIIDADTVG VTFDETSTEE DLTALASLFG AKPVGGDTVL VPGKERGEGF 450
LTQEVFHSHR SETEMMRFLR RLVDKDLALD RAMIPLGSCT MKLNAAAEMM 500
PVSWNTVANL HPFAPAEQVQ GYAKMTSDLE AWLCEITGFA GVSLQPNAGS 550
QGEYAGLMAI RHYHQARGQG HRNICLIPSS AHGTNPASAS MAGMSVVVVN 600
CRPDGDIDID DLKAKAEKHR DNLAAFMITY PSTYGVFEEG IKAFCEIVHD 650
NGGQVYFDGA NLNALVGLAR PADIGADVCH MNLHKTFCIP HGGGGPGVGP 700
IGVAKHLVPY LPGHVEAGSE HAVAAAQFGS ASILVITWMY IRMMGGAGLK 750
KATEAAILNA NYIAHRLKGV YPILYTGAHD RVAHECIVDT RVLKDSAGIT 800
VEDVAKRLID YGFHAPTMSW PVAGTLMIEP TESEPKLEID RLCDAMIAIA 850
GEAKKVADGV WPADDNPLAN APHTASDTLA TEWKHPYTRE EAVFPGGAFD 900
PTAKYWPPVS RVDNVGGDRN LICSCPPVAA YG 932
Length:932
Mass (Da):99,252
Last modified:February 5, 2008 - v1
Checksum:i1A6E0480C0906C32
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000912 Genomic DNA. Translation: ABY39689.1.
RefSeqiYP_001622511.1. NC_010167.1.

Genome annotation databases

EnsemblBacteriaiABY39689; ABY39689; BSUIS_B0715.
GeneIDi5836809.
KEGGibmt:BSUIS_B0715.
PATRICi17865857. VBIBruSui83806_0748.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000912 Genomic DNA. Translation: ABY39689.1 .
RefSeqi YP_001622511.1. NC_010167.1.

3D structure databases

ProteinModelPortali A9WZ23.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 470137.BSUIS_B0715.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY39689 ; ABY39689 ; BSUIS_B0715 .
GeneIDi 5836809.
KEGGi bmt:BSUIS_B0715.
PATRICi 17865857. VBIBruSui83806_0748.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FHQYRSE.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci BSUI470137:GJIC-2721-MONOMER.

Miscellaneous databases

PROi A9WZ23.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23445 / NCTC 10510.

Entry informationi

Entry nameiGCSP_BRUSI
AccessioniPrimary (citable) accession number: A9WZ23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi