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A9WWU1

- PUR9_BRUSI

UniProt

A9WWU1 - PUR9_BRUSI

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, BSUIS_B1294
Organism
Brucella suis (strain ATCC 23445 / NCTC 10510)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciBSUI470137:GJIC-3297-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:BSUIS_B1294
OrganismiBrucella suis (strain ATCC 23445 / NCTC 10510)
Taxonomic identifieri470137 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000008545: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 538538Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000076476Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi470137.BSUIS_B1294.

Structurei

3D structure databases

ProteinModelPortaliA9WWU1.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiCGVATGP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

A9WWU1-1 [UniParc]FASTAAdd to Basket

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MAVSSKHIPA PDLHRVRRAL LSVSDKTGLI DFAKALHANG VEILSTGGTA    50
KSIAAAGIPV KDVSEITGFP EIMDGRVKTL HPAVHGGLLA VRNDPEHVAA 100
MEEHGIGGID LAVINLYPFE EVRFKGGDYD TTVENIDIGG PAMIRASAKN 150
HAYVATVVDP ADYADVVAEL EKHSGSLPLA FRKKLAAKAF SRTAAYDAAI 200
SNWFAEAIDE ETPTYRAVAG KLHSVMRYGE NPHQTAGFYL TGEKRPGVAT 250
ATQLQGKQLS YNNINDTDAA FELVAEFDPA RTAAVAIIKH ANPCGVAEAS 300
TIKEAYLKAL ACDPVSAFGG IVALNRTLDE EAAEEIVKTF TEVIIAPDAT 350
EGAQAIVAAK KNLRLLVTGG LPDPRAKGIA AKTVAGGLLV QSRDNGVVDD 400
LDLKVVTKRA PTEAELNDLK FAFRVGKHVK SNAIVYVKDG ATVGIGAGQM 450
SRVDSARIAA RKAEDAAEAA GLAAPLTKGC VVASDAFFPF ADGLLSAVEA 500
GATAVIQPGG SMRDDEVIAA ADEHGIAMVM TGMRHFRH 538
Length:538
Mass (Da):56,481
Last modified:February 5, 2008 - v1
Checksum:i099349D5160AC19F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000912 Genomic DNA. Translation: ABY40227.1.
RefSeqiYP_001623049.1. NC_010167.1.

Genome annotation databases

EnsemblBacteriaiABY40227; ABY40227; BSUIS_B1294.
GeneIDi5836077.
KEGGibmt:BSUIS_B1294.
PATRICi17867113. VBIBruSui83806_1366.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000912 Genomic DNA. Translation: ABY40227.1 .
RefSeqi YP_001623049.1. NC_010167.1.

3D structure databases

ProteinModelPortali A9WWU1.
ModBasei Search...

Protein-protein interaction databases

STRINGi 470137.BSUIS_B1294.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY40227 ; ABY40227 ; BSUIS_B1294 .
GeneIDi 5836077.
KEGGi bmt:BSUIS_B1294.
PATRICi 17867113. VBIBruSui83806_1366.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi CGVATGP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci BSUI470137:GJIC-3297-MONOMER.

Miscellaneous databases

PROi A9WWU1.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23445 / NCTC 10510.

Entry informationi

Entry nameiPUR9_BRUSI
AccessioniPrimary (citable) accession number: A9WWU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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