ID   HYPRE_BRUSI             Reviewed;         333 AA.
AC   A9WWR5;
DT   25-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   16-JUN-2009, entry version 11.
DE   RecName: Full=4-hydroxyproline epimerase;
DE            EC=5.1.1.8;
DE   AltName: Full=Hydroxyproline-2-epimerase;
DE            Short=HyPRE;
GN   OrderedLocusNames=BSUIS_B1268;
OS   Brucella suis (strain ATCC 23445 / NCTC 10510).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Brucellaceae; Brucella.
OX   NCBI_TaxID=470137;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Setubal J.C., Bowns C., Boyle S., Crasta O.R., Czar M.J.,
RA   Dharmanolla C., Gillespie J.J., Kenyon R.W., Lu J., Mane S.,
RA   Mohapatra S., Nagrani S., Purkayastha A., Rajasimha H.K.,
RA   Shallom J.M., Shallom S., Shukla M., Snyder E.E., Sobral B.W.,
RA   Wattam A.R., Will R., Williams K., Yoo H., Bruce D., Detter C.,
RA   Munk C., Brettin T.S.;
RT   "Brucella suis ATCC 23445 whole genome shotgun sequencing project.";
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Allows intracellular utilization of 4-hydroxyproline,
CC       one of the major constituents of host collagen, by converting 4-
CC       hydroxy-L-proline to 4-hydroxy-D-proline, which can be further
CC       metabolized by intracellular 4-hydroxy-D-proline oxidases. Strong
CC       B-cell mitogen. Plays an important role in the regulation of
CC       intra- and extracellular amino acid pools, allowing the bacterium
CC       to profit from host precursors and enzymatic pathways (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Trans-4-hydroxy-L-proline = cis-4-hydroxy-D-
CC       proline.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SIMILARITY: Belongs to the proline racemase family. 4-
CC       hydroxyproline epimerase subfamily.
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DR   EMBL; CP000912; ABY40201.1; -; Genomic_DNA.
DR   RefSeq; YP_001623023.1; -.
DR   GeneID; 5836132; -.
DR   GenomeReviews; CP000912_GR; BSUIS_B1268.
DR   KEGG; bmt:BSUIS_B1268; -.
DR   OMA; A9WWR5; GNFYAII.
DR   GO; GO:0047580; F:4-hydroxyproline epimerase activity; IEA:EC.
DR   GO; GO:0018112; F:proline racemase activity; IEA:InterPro.
DR   InterPro; IPR008794; Pro_racemase.
DR   Pfam; PF05544; Pro_racemase; 1.
DR   PIRSF; PIRSF029792; Pro_racemase; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Isomerase.
FT   CHAIN         1    333       4-hydroxyproline epimerase.
FT                                /FTId=PRO_0000354031.
FT   ACT_SITE     90     90       Proton acceptor (By similarity).
FT   ACT_SITE    253    253       Proton donor (By similarity).
SQ   SEQUENCE   333 AA;  36593 MW;  0963CC7E039F5717 CRC64;
     MARHSFFCVD GHTCGNPVRL VAGGGPNLNG STMMEKRAHF LAEYDWIRTG LMFEPRGHDM
     MSGSILYPPT RPDCDVAVLF IETSGCLPMC GHGTIGTVTM AIEQGLVTPK TPGKLNLDTP
     AGLVAIEYEQ DGQYVERVRL TNVPAFLYAE GLEVECPDLG PIKVDVAYGG NFYAIVEPQE
     NYTDMDDYSA LQLIAWSPVL RQRLNEKYKF QHPELPDINR LSHILWTGKP EHPQAHARNA
     VFYGDKAIDR SPCGTGTSAR MAQLAAKGKL KPGDEFIHES IIGSLFHGRV ERAAEVAGRP
     AIVPSIAGWA RMTGYNTIFI DDRDPFAHGF SVA
//