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Protein

Glutamate decarboxylase

Gene

RSal33209_2078

Organism
Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciRSAL288705:GHX1-2078-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Ordered Locus Names:RSal33209_2078Imported
OrganismiRenibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)Imported
Taxonomic identifieri288705 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeRenibacterium
ProteomesiUP000002007 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi288705.RSal33209_2078.

Structurei

3D structure databases

ProteinModelPortaliA9WSM2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiFVGTWMD.
OrthoDBiEOG6TFCPW.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

A9WSM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSTGSRPDR DDQQPIDLNP LFTRPGERTE FPKFTLRKEG SLPETAYQIV
60 70 80 90 100
HDDAMLDGNA RQNLATFVGT WMDEHANQLY LESADKNMID KDEYPHTAAI
110 120 130 140 150
ETRCWRILAT LWNAPNAEKA IGTSTIGSSE ACMLGGLALK RRWQHARRAA
160 170 180 190 200
GLATDKPNLV LSSAVQVCWE KFCNYWDVEP RYVPISEEHR VLDGHDLDKY
210 220 230 240 250
VDENTIGVVA ILGVTYTGMY EPVQQIAAAL DQIQANTGLD VRIHVDGASG
260 270 280 290 300
AMIAPFLQPD LEWDFHVPRV SSINISGHKY GLVYPGVGWI VWRDASLLPE
310 320 330 340 350
DLVFRVSYLG GDMPTFALNF SRPGAQVLLQ YYQFLRLGFD GFEAVQNACR
360 370 380 390 400
EVALYLSGEI AGMEPFELWN DGSDIPVFAW RLKPDPERHW DLHQLSDRLR
410 420 430 440 450
MSGWQVPSYP MPADLENITV QRIVVRSGFS KNLAADFLGD FREQVAYLES
460
LPAPVSTNRE STGFRH
Length:466
Mass (Da):52,535
Last modified:February 5, 2008 - v1
Checksum:iBCABF696C8FF9168
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000910 Genomic DNA. Translation: ABY23810.1.
RefSeqiWP_012245480.1. NC_010168.1.
YP_001625224.1. NC_010168.1.

Genome annotation databases

EnsemblBacteriaiABY23810; ABY23810; RSal33209_2078.
KEGGirsa:RSal33209_2078.
PATRICi23077503. VBIRenSal21953_2167.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000910 Genomic DNA. Translation: ABY23810.1.
RefSeqiWP_012245480.1. NC_010168.1.
YP_001625224.1. NC_010168.1.

3D structure databases

ProteinModelPortaliA9WSM2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi288705.RSal33209_2078.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABY23810; ABY23810; RSal33209_2078.
KEGGirsa:RSal33209_2078.
PATRICi23077503. VBIRenSal21953_2167.

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiFVGTWMD.
OrthoDBiEOG6TFCPW.

Enzyme and pathway databases

BioCyciRSAL288705:GHX1-2078-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the fish pathogen Renibacterium salmoninarum suggests reductive evolution away from an environmental Arthrobacter ancestor."
    Wiens G.D., Rockey D.D., Wu Z., Chang J., Levy R., Crane S., Chen D.S., Capri G.R., Burnett J.R., Sudheesh P.S., Schipma M.J., Burd H., Bhattacharyya A., Rhodes L.D., Kaul R., Strom M.S.
    J. Bacteriol. 190:6970-6982(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235Imported.

Entry informationi

Entry nameiA9WSM2_RENSM
AccessioniPrimary (citable) accession number: A9WSM2
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: April 29, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.