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A9WSJ0 (UPPP_RENSM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:RSal33209_2045
OrganismRenibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235) [Complete proteome] [HAMAP]
Taxonomic identifier288705 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeRenibacterium

Protein attributes

Sequence length280 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 280280Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000197394

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane40 – 6021Helical; Potential
Transmembrane89 – 10921Helical; Potential
Transmembrane116 – 13621Helical; Potential
Transmembrane146 – 16621Helical; Potential
Transmembrane191 – 21121Helical; Potential
Transmembrane227 – 24721Helical; Potential
Transmembrane260 – 28021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A9WSJ0 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: F5FD690D742AE387

FASTA28030,219
        10         20         30         40         50         60 
MEWIQAAILG IVQGLTEFLP ISSSAHIFIV GKLMGLGDPG AAFTAVSQLG TEAAVIVFFW 

        70         80         90        100        110        120 
RDIVRIIKHW GLSIAGKIPR NDPDARMGWL VVAGSIPIIV VGLFFQNAIE VTFRNLWIVA 

       130        140        150        160        170        180 
TTLIVFGVIL AVADAVGKHE RKLEELTVKH GILYGLAQCL ALIPGVSRSG GTITAGLLMG 

       190        200        210        220        230        240 
YTREAAARYS FLLAIPAVLG SGFYELFKIV AKHENAGDTF NLGQTALATV IAFVVGYLII 

       250        260        270        280 
GWFLKFISHN SYRGFVWYRI ALGLVVFVLL GFGVIPATLS 

« Hide

References

[1]"Genome sequence of the fish pathogen Renibacterium salmoninarum suggests reductive evolution away from an environmental Arthrobacter ancestor."
Wiens G.D., Rockey D.D., Wu Z., Chang J., Levy R., Crane S., Chen D.S., Capri G.R., Burnett J.R., Sudheesh P.S., Schipma M.J., Burd H., Bhattacharyya A., Rhodes L.D., Kaul R., Strom M.S.
J. Bacteriol. 190:6970-6982(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000910 Genomic DNA. Translation: ABY23778.1.
RefSeqYP_001625192.1. NC_010168.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING288705.RSal33209_2045.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABY23778; ABY23778; RSal33209_2045.
GeneID5822051.
KEGGrsa:RSal33209_2045.
PATRIC23077433. VBIRenSal21953_2133.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAIEGPFRD.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycRSAL288705:GHX1-2045-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_RENSM
AccessionPrimary (citable) accession number: A9WSJ0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 5, 2008
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families