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A9WS85

- SYL_RENSM

UniProt

A9WS85 - SYL_RENSM

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei630 – 6301ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRSAL288705:GHX1-1940-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:RSal33209_1940
    OrganismiRenibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)
    Taxonomic identifieri288705 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeRenibacterium
    ProteomesiUP000002007: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 862862Leucine--tRNA ligasePRO_0000334801Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi288705.RSal33209_1940.

    Structurei

    3D structure databases

    ProteinModelPortaliA9WS85.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi79 – 8911"HIGH" regionAdd
    BLAST
    Motifi627 – 6315"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9WS85-1 [UniParc]FASTAAdd to Basket

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    MVQSRGFSLS SVRNGTEGNT MSQHTSQPAA DVPVDVADEN RYDIAAIEAK    50
    WLPRWEEANI FAPLDDGSKE RRYVCDMFPY PSGDLHMGHA EAFVMGDVVG 100
    RYWKLKGFDV LHPVGWDSFG LPAENAAIKR NAHPAEWTYA NIETQAASFK 150
    RYAIGVDWSR RLQTSDPEYY RWTQWLFLRF YERGLAYRKN SPVNWCPKDL 200
    TVLANEQVIN GACERCGTPV TKKNLNQWYF KITDYADRLL DDMAQLEGHW 250
    PERVLAMQRN WIGRSQGAHV DFVIDGMSDA ETGEAKKVTV FTTRPDTLYG 300
    ATFFAVAVDA ALADELVTEE QRAELSAYQE RVKHLSDIER QESDREKTGV 350
    FLGRYAINPI DGEMLPIWAA DYVLADYGTG AIMAVPAHDQ RDLDFARAFD 400
    LPVRQVLDTG AENPAETGTA AIGDGVLVNS GELDGLAKAE AIPAAISLLS 450
    KIGTGEATTN YRLRDWLLSR QRFWGAPVPI IHCAECGEVP VPDDQLPVRL 500
    PENLRGEQLA PKGTSPLASV ADWVNVDCPK CGGAATRDTD TIDTFVDSSW 550
    YYLRYTSPEY TDGPFDPAAA TRWMGVDQYV GGVEHAILHL LYSRFFVKVL 600
    NDLGLLEAKE PFKALLNQGQ VLNGGKAMSK SLGNGVDLSQ QLDRFGVDAV 650
    RLTMVFASPP EDDVDWADVS PSGSAKFLAR AWRLAQDVTS EIGVDPATGD 700
    RALRSVTHRT LSEAADLIDA HKFNVVVAKT MELVNITRKS IDSGCGPADP 750
    AVREAVEAVA VILSLFAPYT AEDIWAELGH QDFVARASWP TVDDSLLVQS 800
    TITAVVQVQG KVRDRLEVPT DITEDQLREL ALASEIVQKT LDGRGIRTVI 850
    VRAPKLVNIV PA 862
    Length:862
    Mass (Da):95,215
    Last modified:May 20, 2008 - v2
    Checksum:iF244F35CF99EC356
    GO

    Sequence cautioni

    The sequence ABY23673.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000910 Genomic DNA. Translation: ABY23673.1. Different initiation.
    RefSeqiYP_001625087.1. NC_010168.1.

    Genome annotation databases

    EnsemblBacteriaiABY23673; ABY23673; RSal33209_1940.
    GeneIDi5822648.
    KEGGirsa:RSal33209_1940.
    PATRICi23077217. VBIRenSal21953_2025.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000910 Genomic DNA. Translation: ABY23673.1 . Different initiation.
    RefSeqi YP_001625087.1. NC_010168.1.

    3D structure databases

    ProteinModelPortali A9WS85.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 288705.RSal33209_1940.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABY23673 ; ABY23673 ; RSal33209_1940 .
    GeneIDi 5822648.
    KEGGi rsa:RSal33209_1940.
    PATRICi 23077217. VBIRenSal21953_2025.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci RSAL288705:GHX1-1940-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the fish pathogen Renibacterium salmoninarum suggests reductive evolution away from an environmental Arthrobacter ancestor."
      Wiens G.D., Rockey D.D., Wu Z., Chang J., Levy R., Crane S., Chen D.S., Capri G.R., Burnett J.R., Sudheesh P.S., Schipma M.J., Burd H., Bhattacharyya A., Rhodes L.D., Kaul R., Strom M.S.
      J. Bacteriol. 190:6970-6982(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235.

    Entry informationi

    Entry nameiSYL_RENSM
    AccessioniPrimary (citable) accession number: A9WS85
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3