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A9WS85

- SYL_RENSM

UniProt

A9WS85 - SYL_RENSM

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Protein
Leucine--tRNA ligase
Gene
leuS, RSal33209_1940
Organism
Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei630 – 6301ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRSAL288705:GHX1-1940-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:RSal33209_1940
OrganismiRenibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)
Taxonomic identifieri288705 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeRenibacterium
ProteomesiUP000002007: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 862862Leucine--tRNA ligaseUniRule annotation
PRO_0000334801Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi288705.RSal33209_1940.

Structurei

3D structure databases

ProteinModelPortaliA9WS85.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi79 – 8911"HIGH" regionUniRule annotation
Add
BLAST
Motifi627 – 6315"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9WS85-1 [UniParc]FASTAAdd to Basket

« Hide

MVQSRGFSLS SVRNGTEGNT MSQHTSQPAA DVPVDVADEN RYDIAAIEAK    50
WLPRWEEANI FAPLDDGSKE RRYVCDMFPY PSGDLHMGHA EAFVMGDVVG 100
RYWKLKGFDV LHPVGWDSFG LPAENAAIKR NAHPAEWTYA NIETQAASFK 150
RYAIGVDWSR RLQTSDPEYY RWTQWLFLRF YERGLAYRKN SPVNWCPKDL 200
TVLANEQVIN GACERCGTPV TKKNLNQWYF KITDYADRLL DDMAQLEGHW 250
PERVLAMQRN WIGRSQGAHV DFVIDGMSDA ETGEAKKVTV FTTRPDTLYG 300
ATFFAVAVDA ALADELVTEE QRAELSAYQE RVKHLSDIER QESDREKTGV 350
FLGRYAINPI DGEMLPIWAA DYVLADYGTG AIMAVPAHDQ RDLDFARAFD 400
LPVRQVLDTG AENPAETGTA AIGDGVLVNS GELDGLAKAE AIPAAISLLS 450
KIGTGEATTN YRLRDWLLSR QRFWGAPVPI IHCAECGEVP VPDDQLPVRL 500
PENLRGEQLA PKGTSPLASV ADWVNVDCPK CGGAATRDTD TIDTFVDSSW 550
YYLRYTSPEY TDGPFDPAAA TRWMGVDQYV GGVEHAILHL LYSRFFVKVL 600
NDLGLLEAKE PFKALLNQGQ VLNGGKAMSK SLGNGVDLSQ QLDRFGVDAV 650
RLTMVFASPP EDDVDWADVS PSGSAKFLAR AWRLAQDVTS EIGVDPATGD 700
RALRSVTHRT LSEAADLIDA HKFNVVVAKT MELVNITRKS IDSGCGPADP 750
AVREAVEAVA VILSLFAPYT AEDIWAELGH QDFVARASWP TVDDSLLVQS 800
TITAVVQVQG KVRDRLEVPT DITEDQLREL ALASEIVQKT LDGRGIRTVI 850
VRAPKLVNIV PA 862
Length:862
Mass (Da):95,215
Last modified:May 20, 2008 - v2
Checksum:iF244F35CF99EC356
GO

Sequence cautioni

The sequence ABY23673.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000910 Genomic DNA. Translation: ABY23673.1. Different initiation.
RefSeqiYP_001625087.1. NC_010168.1.

Genome annotation databases

EnsemblBacteriaiABY23673; ABY23673; RSal33209_1940.
GeneIDi5822648.
KEGGirsa:RSal33209_1940.
PATRICi23077217. VBIRenSal21953_2025.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000910 Genomic DNA. Translation: ABY23673.1 . Different initiation.
RefSeqi YP_001625087.1. NC_010168.1.

3D structure databases

ProteinModelPortali A9WS85.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 288705.RSal33209_1940.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY23673 ; ABY23673 ; RSal33209_1940 .
GeneIDi 5822648.
KEGGi rsa:RSal33209_1940.
PATRICi 23077217. VBIRenSal21953_2025.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci RSAL288705:GHX1-1940-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the fish pathogen Renibacterium salmoninarum suggests reductive evolution away from an environmental Arthrobacter ancestor."
    Wiens G.D., Rockey D.D., Wu Z., Chang J., Levy R., Crane S., Chen D.S., Capri G.R., Burnett J.R., Sudheesh P.S., Schipma M.J., Burd H., Bhattacharyya A., Rhodes L.D., Kaul R., Strom M.S.
    J. Bacteriol. 190:6970-6982(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235.

Entry informationi

Entry nameiSYL_RENSM
AccessioniPrimary (citable) accession number: A9WS85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 45 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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