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A9WS85

- SYL_RENSM

UniProt

A9WS85 - SYL_RENSM

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei630 – 6301ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRSAL288705:GHX1-1940-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:RSal33209_1940
OrganismiRenibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)
Taxonomic identifieri288705 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeRenibacterium
ProteomesiUP000002007: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 862862Leucine--tRNA ligasePRO_0000334801Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi288705.RSal33209_1940.

Structurei

3D structure databases

ProteinModelPortaliA9WS85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi79 – 8911"HIGH" regionAdd
BLAST
Motifi627 – 6315"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9WS85-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVQSRGFSLS SVRNGTEGNT MSQHTSQPAA DVPVDVADEN RYDIAAIEAK
60 70 80 90 100
WLPRWEEANI FAPLDDGSKE RRYVCDMFPY PSGDLHMGHA EAFVMGDVVG
110 120 130 140 150
RYWKLKGFDV LHPVGWDSFG LPAENAAIKR NAHPAEWTYA NIETQAASFK
160 170 180 190 200
RYAIGVDWSR RLQTSDPEYY RWTQWLFLRF YERGLAYRKN SPVNWCPKDL
210 220 230 240 250
TVLANEQVIN GACERCGTPV TKKNLNQWYF KITDYADRLL DDMAQLEGHW
260 270 280 290 300
PERVLAMQRN WIGRSQGAHV DFVIDGMSDA ETGEAKKVTV FTTRPDTLYG
310 320 330 340 350
ATFFAVAVDA ALADELVTEE QRAELSAYQE RVKHLSDIER QESDREKTGV
360 370 380 390 400
FLGRYAINPI DGEMLPIWAA DYVLADYGTG AIMAVPAHDQ RDLDFARAFD
410 420 430 440 450
LPVRQVLDTG AENPAETGTA AIGDGVLVNS GELDGLAKAE AIPAAISLLS
460 470 480 490 500
KIGTGEATTN YRLRDWLLSR QRFWGAPVPI IHCAECGEVP VPDDQLPVRL
510 520 530 540 550
PENLRGEQLA PKGTSPLASV ADWVNVDCPK CGGAATRDTD TIDTFVDSSW
560 570 580 590 600
YYLRYTSPEY TDGPFDPAAA TRWMGVDQYV GGVEHAILHL LYSRFFVKVL
610 620 630 640 650
NDLGLLEAKE PFKALLNQGQ VLNGGKAMSK SLGNGVDLSQ QLDRFGVDAV
660 670 680 690 700
RLTMVFASPP EDDVDWADVS PSGSAKFLAR AWRLAQDVTS EIGVDPATGD
710 720 730 740 750
RALRSVTHRT LSEAADLIDA HKFNVVVAKT MELVNITRKS IDSGCGPADP
760 770 780 790 800
AVREAVEAVA VILSLFAPYT AEDIWAELGH QDFVARASWP TVDDSLLVQS
810 820 830 840 850
TITAVVQVQG KVRDRLEVPT DITEDQLREL ALASEIVQKT LDGRGIRTVI
860
VRAPKLVNIV PA
Length:862
Mass (Da):95,215
Last modified:May 20, 2008 - v2
Checksum:iF244F35CF99EC356
GO

Sequence cautioni

The sequence ABY23673.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000910 Genomic DNA. Translation: ABY23673.1. Different initiation.
RefSeqiYP_001625087.1. NC_010168.1.

Genome annotation databases

EnsemblBacteriaiABY23673; ABY23673; RSal33209_1940.
GeneIDi5822648.
KEGGirsa:RSal33209_1940.
PATRICi23077217. VBIRenSal21953_2025.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000910 Genomic DNA. Translation: ABY23673.1 . Different initiation.
RefSeqi YP_001625087.1. NC_010168.1.

3D structure databases

ProteinModelPortali A9WS85.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 288705.RSal33209_1940.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY23673 ; ABY23673 ; RSal33209_1940 .
GeneIDi 5822648.
KEGGi rsa:RSal33209_1940.
PATRICi 23077217. VBIRenSal21953_2025.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci RSAL288705:GHX1-1940-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the fish pathogen Renibacterium salmoninarum suggests reductive evolution away from an environmental Arthrobacter ancestor."
    Wiens G.D., Rockey D.D., Wu Z., Chang J., Levy R., Crane S., Chen D.S., Capri G.R., Burnett J.R., Sudheesh P.S., Schipma M.J., Burd H., Bhattacharyya A., Rhodes L.D., Kaul R., Strom M.S.
    J. Bacteriol. 190:6970-6982(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235.

Entry informationi

Entry nameiSYL_RENSM
AccessioniPrimary (citable) accession number: A9WS85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 47 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3