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Protein

Probable malate:quinone oxidoreductase

Gene

mqo

Organism
Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable malate:quinone oxidoreductase (mqo)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciRSAL288705:GHX1-1912-MONOMER.
UniPathwayiUPA00223; UER01008.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate:quinone oxidoreductaseUniRule annotation (EC:1.1.5.4UniRule annotation)
Alternative name(s):
MQOUniRule annotation
Malate dehydrogenase [quinone]UniRule annotation
Gene namesi
Name:mqoUniRule annotation
Ordered Locus Names:RSal33209_1912
OrganismiRenibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)
Taxonomic identifieri288705 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeRenibacterium
Proteomesi
  • UP000002007 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 495495Probable malate:quinone oxidoreductasePRO_1000078035Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi288705.RSal33209_1912.

Structurei

3D structure databases

ProteinModelPortaliA9WQR6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DWT. Bacteria.
COG0579. LUCA.
HOGENOMiHOG000109379.
KOiK00116.
OMAiEPIAATK.
OrthoDBiEOG6X6R8Z.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_00212. MQO.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR006231. MQO.
[Graphical view]
PfamiPF06039. Mqo. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.

Sequencei

Sequence statusi: Complete.

A9WQR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFISQTKEA DVVFIGGGIM SATLGAMIRQ IQPDWSVVVF EQLNELGQES
60 70 80 90 100
SGPWNNAGTG HSALCELNYT PAAKDGSVEA SKALAINEQF QLSRQFWSHM
110 120 130 140 150
VDKQFIGSPK NFINTVPHMS FVMGKDHTDF LRTRYEALKP NPLFSSMEFS
160 170 180 190 200
SDPSQIEKWA PLVMKGRSGN GPVAATRAAE GTDVDFGQLT KELVGYLGNN
210 220 230 240 250
DAEINYGTTV TDIQRGTDKR WHLKLKHKAS GEHGAIKARF VFIGSGGGAL
260 270 280 290 300
HLLQRSGIPQ GKGYGGFPVS GQFFRCTNEE IAAQHSAKVY GQASVGAPPM
310 320 330 340 350
SVPHLDTRYV GGKKSLLFGP YAGFSTNFLK SGSLWDLPLS IRPSNIYPMA
360 370 380 390 400
AAGLHNLGLT KYLVSEVLKT RSSKVTAMQE YFPQADGNDW ELITAGQRVQ
410 420 430 440 450
IMKKDRKQGG ILQFGTEVIT SSDGSIGALL GASPGASTAV PIMLELLQRC
460 470 480 490
FPREFKLQWQ DQLKDMIPTL GTKLNDNAEL AAATMARTAA TLQLD
Length:495
Mass (Da):53,745
Last modified:February 5, 2008 - v1
Checksum:i8154744C10162717
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000910 Genomic DNA. Translation: ABY23645.1.
RefSeqiWP_012245316.1. NC_010168.1.

Genome annotation databases

EnsemblBacteriaiABY23645; ABY23645; RSal33209_1912.
KEGGirsa:RSal33209_1912.
PATRICi23077159. VBIRenSal21953_1996.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000910 Genomic DNA. Translation: ABY23645.1.
RefSeqiWP_012245316.1. NC_010168.1.

3D structure databases

ProteinModelPortaliA9WQR6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi288705.RSal33209_1912.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABY23645; ABY23645; RSal33209_1912.
KEGGirsa:RSal33209_1912.
PATRICi23077159. VBIRenSal21953_1996.

Phylogenomic databases

eggNOGiENOG4105DWT. Bacteria.
COG0579. LUCA.
HOGENOMiHOG000109379.
KOiK00116.
OMAiEPIAATK.
OrthoDBiEOG6X6R8Z.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01008.
BioCyciRSAL288705:GHX1-1912-MONOMER.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_00212. MQO.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR006231. MQO.
[Graphical view]
PfamiPF06039. Mqo. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the fish pathogen Renibacterium salmoninarum suggests reductive evolution away from an environmental Arthrobacter ancestor."
    Wiens G.D., Rockey D.D., Wu Z., Chang J., Levy R., Crane S., Chen D.S., Capri G.R., Burnett J.R., Sudheesh P.S., Schipma M.J., Burd H., Bhattacharyya A., Rhodes L.D., Kaul R., Strom M.S.
    J. Bacteriol. 190:6970-6982(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235.

Entry informationi

Entry nameiMQO_RENSM
AccessioniPrimary (citable) accession number: A9WQR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: November 11, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.