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A9WQ90 (ASSY_RENSM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Argininosuccinate synthase

EC=6.3.4.5
Alternative name(s):
Citrulline--aspartate ligase
Gene names
Name:argG
Ordered Locus Names:RSal33209_0783
OrganismRenibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235) [Complete proteome] [HAMAP]
Taxonomic identifier288705 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeRenibacterium

Protein attributes

Sequence length420 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate. HAMAP-Rule MF_00005

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. HAMAP-Rule MF_00005

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00005

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00005.

Sequence similarities

Belongs to the argininosuccinate synthase family. Type 1 subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

argininosuccinate synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 420420Argininosuccinate synthase HAMAP-Rule MF_00005
PRO_0000329472

Regions

Nucleotide binding23 – 319ATP By similarity

Sites

Binding site1021Citrulline By similarity
Binding site1321ATP; via amide nitrogen By similarity
Binding site1341Aspartate By similarity
Binding site1381Aspartate By similarity
Binding site1381Citrulline By similarity
Binding site1391Aspartate By similarity
Binding site1421Citrulline By similarity
Binding site1901Citrulline By similarity
Binding site2741Citrulline By similarity
Binding site2861Citrulline By similarity

Sequences

Sequence LengthMass (Da)Tools
A9WQ90 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: F77DB6A364E0F337

FASTA42045,875
        10         20         30         40         50         60 
MLKMHPNINK YEGVPVTDRI VLAYSGGLDT SVAIGWIGEA TGAEVIAVAV DVGQGGESLE 

        70         80         90        100        110        120 
TVRQRALGCG AVEAYVADAR DEFANEYCMP TLKANALYQG HYPLVSAISR PVIVKHLVKA 

       130        140        150        160        170        180 
AREFGATTVA HGCTGKGNDQ VRFEVGIQTL GPDLKCIAPV RDLALTRDKA IEYAERNNLP 

       190        200        210        220        230        240 
IETTKKNPYS IDQNVWGRAV ETGYLEDIWN APTKDIYDYT ATPEFPPAPD EAVISFRAGV 

       250        260        270        280        290        300 
PVALDGVLLS PLQVIQELNR RAGAQGVGRI DVVEDRLVGI KSREIYEAPG AMTLITAHKH 

       310        320        330        340        350        360 
LEDVTIEREQ ARFKATVSQR WAELVYDGQW FSPLKRSLDV FIDDTQKYVS GDIRVVLHAG 

       370        380        390        400        410        420 
VASVNGRRTD TGLYDFNLAT YDTGDTFDQS QARGFIELWG LSAKTATTRD ERVAASGENA 

« Hide

References

[1]"Genome sequence of the fish pathogen Renibacterium salmoninarum suggests reductive evolution away from an environmental Arthrobacter ancestor."
Wiens G.D., Rockey D.D., Wu Z., Chang J., Levy R., Crane S., Chen D.S., Capri G.R., Burnett J.R., Sudheesh P.S., Schipma M.J., Burd H., Bhattacharyya A., Rhodes L.D., Kaul R., Strom M.S.
J. Bacteriol. 190:6970-6982(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000910 Genomic DNA. Translation: ABY22530.1.
RefSeqYP_001623944.1. NC_010168.1.

3D structure databases

ProteinModelPortalA9WQ90.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING288705.RSal33209_0783.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABY22530; ABY22530; RSal33209_0783.
GeneID5821489.
KEGGrsa:RSal33209_0783.
PATRIC23074746. VBIRenSal21953_0803.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0137.
HOGENOMHOG000230093.
KOK01940.
OMAKANALYM.
OrthoDBEOG6K9QCV.

Enzyme and pathway databases

BioCycRSAL288705:GHX1-783-MONOMER.
UniPathwayUPA00068; UER00113.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPMF_00005. Arg_succ_synth_type1.
InterProIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsTIGR00032. argG. 1 hit.
PROSITEPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASSY_RENSM
AccessionPrimary (citable) accession number: A9WQ90
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: February 5, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways