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A9WPH5 (A9WPH5_RENSM) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase HAMAP MF_00323
EC=4.99.1.1 HAMAP MF_00323
Alternative name(s):
Heme synthase HAMAP MF_00323
Protoheme ferro-lyase HAMAP MF_00323
Gene names
Name:hemH HAMAP MF_00323
Ordered Locus Names:RSal33209_1222
OrganismRenibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235) [Complete proteome] [HAMAP] EMBL ABY22960.1
Taxonomic identifier288705 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Renibacterium

Protein attributes

Sequence length397 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX By similarity. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family. HAMAP MF_00323

Ontologies

Keywords
   Biological processHeme biosynthesis HAMAP MF_00323
Porphyrin biosynthesis HAMAP MF_00323
   Cellular componentCytoplasm HAMAP MF_00323
   LigandIron HAMAP MF_00323
Metal-binding HAMAP MF_00323
   Molecular functionLyase HAMAP MF_00323 EMBL ABY22960.1
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding2031Iron By similarity HAMAP MF_00323
Metal binding3021Iron By similarity HAMAP MF_00323

Sequences

Sequence LengthMass (Da)Tools
A9WPH5 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: A66AF470C8E634AA

FASTA39743,231
        10         20         30         40         50         60 
MSISPMSKNA ITERGRMAAK DYDAILLASF GGPEGQDDVI PFLRNVTRGR GIPDERLEEV 

        70         80         90        100        110        120 
SHHYRAFGGI SPINEQNRAL KLALETELAA RGIELPVLWG NRNWDPYIPE VLQEAYDAGH 

       130        140        150        160        170        180 
RRILTVTTSA YSCYSSCRQY REDLGMALVD SGLDGKLEVD KVRQYFDHPG FVEPFIEGTT 

       190        200        210        220        230        240 
AGLAKVRSEL SSDEKIHVLF ATHSIPTRDA EAAGNSAEEP REFAEGSAYV AQHLAAATAV 

       250        260        270        280        290        300 
MAQVDAASAE PTDWSLVYQS RSGAPHVPWL EPDISDAMEE LAEQGVRGVV VVPLGFVSDH 

       310        320        330        340        350        360 
MEVVWDLDTE AKETAEKLNM AFDRVPTPGT HQKFVAGLVD LVCERTLANN IADRPAMTPL 

       370        380        390 
GPWYDVCRPG CCTNFRGEKP TIAGADTLVG TVAAASA

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References

[1]"Genome sequence of the fish pathogen Renibacterium salmoninarum suggests reductive evolution away from an environmental Arthrobacter ancestor."
Wiens G.D., Rockey D.D., Wu Z., Chang J., Levy R., Crane S., Chen D.S., Capri G.R., Burnett J.R., Sudheesh P.S., Schipma M.J., Burd H., Bhattacharyya A., Rhodes L.D., Kaul R., Strom M.S.
J. Bacteriol. 190:6970-6982(2008) [PubMed: 18723615] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000910 Genomic DNA. Translation: ABY22960.1.
RefSeqYP_001624374.1. NC_010168.1.

3D structure databases

ProteinModelPortalA9WPH5.
ModBaseSearch...

Protein-protein interaction databases

STRINGA9WPH5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5822477.
GenomeReviewsGene locus RSal33209_1222 in contig CP000910_GR.
KEGGrsa:RSal33209_1222.
PATRIC23075685. VBIRenSal21953_1263.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG697135.
OMAPAVVMAP.
ProtClustDBPRK00035.

Enzyme and pathway databases

BioCycRSAL288705:RSAL33209_1222-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA9WPH5_RENSM
AccessionPrimary (citable) accession number: A9WPH5
Entry history
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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