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A9WPH2 (A9WPH2_RENSM) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP-Rule MF_00218 SAAS SAAS000257

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP-Rule MF_00218 SAAS SAAS000257 RuleBase RU000554

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP-Rule MF_00218 SAAS SAAS000257 RuleBase RU000554

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00218 SAAS SAAS000257

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00218 SAAS SAAS000257.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family. HAMAP-Rule MF_00218

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region54 – 585Substrate binding By similarity HAMAP-Rule MF_00218

Sites

Binding site1031Substrate By similarity HAMAP-Rule MF_00218
Binding site1781Substrate By similarity HAMAP-Rule MF_00218
Binding site2331Substrate By similarity HAMAP-Rule MF_00218
Binding site3471Substrate By similarity HAMAP-Rule MF_00218
Site1031Transition state stabilizer By similarity HAMAP-Rule MF_00218

Sequences

Sequence LengthMass (Da)Tools
A9WPH2 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 006FF70B2DF696E3

FASTA37840,693
        10         20         30         40         50         60 
MTGCRYLSDE TTGRIEVMTL NSSHPLIDGR TTESPLIMAY SGKTPSRRPV WFMRQAGRSL 

        70         80         90        100        110        120 
PEYRKVREGI SMLDSCLKPD LASEITLQPV RRHDVDAAIF FSDIVIPLKL AGVGVDIVPG 

       130        140        150        160        170        180 
VGPVLEKPVR TLADVRALPK LTEDSLEPIR QAVALTVAEL GNTPLIGFAG APFTLAAYMV 

       190        200        210        220        230        240 
EGKPSRDHLG PRTMMHADPQ AWQELAAWAA DASGMFLRAQ LEAGASAAQL FDSWAGSLGL 

       250        260        270        280        290        300 
SDYQTHVAPA SKQALDHVRD LGAPLIHFGT GTSELLLAMR DVGVDVIGVD YRLPLDEANR 

       310        320        330        340        350        360 
RLGGMTPLQG NIDPALLPAP WPVLEAHILD VLRRGESAPG NVVNLGHGVP PETDPSVLSR 

       370 
IVELVHSVDP VRTDDQSA 

« Hide

References

[1]"Genome sequence of the fish pathogen Renibacterium salmoninarum suggests reductive evolution away from an environmental Arthrobacter ancestor."
Wiens G.D., Rockey D.D., Wu Z., Chang J., Levy R., Crane S., Chen D.S., Capri G.R., Burnett J.R., Sudheesh P.S., Schipma M.J., Burd H., Bhattacharyya A., Rhodes L.D., Kaul R., Strom M.S.
J. Bacteriol. 190:6970-6982(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000910 Genomic DNA. Translation: ABY22957.1.
RefSeqYP_001624371.1. NC_010168.1.

3D structure databases

ProteinModelPortalA9WPH2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING288705.RSal33209_1219.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABY22957; ABY22957; RSal33209_1219.
GeneID5822474.
KEGGrsa:RSal33209_1219.
PATRIC23075679. VBIRenSal21953_1260.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0407.
HOGENOMHOG000253897.
KOK01599.
OMAEMVCEIT.
OrthoDBEOG6VXF6H.

Enzyme and pathway databases

BioCycRSAL288705:GHX1-1219-MONOMER.
UniPathwayUPA00251; UER00321.

Family and domain databases

HAMAPMF_00218. URO_D.
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. hemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA9WPH2_RENSM
AccessionPrimary (citable) accession number: A9WPH2
Entry history
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: June 11, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)