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A9WPH2

- A9WPH2_RENSM

UniProt

A9WPH2 - A9WPH2_RENSM

Protein

Uroporphyrinogen decarboxylase

Gene

hemE

Organism
Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.UniRule annotationSAAS annotation

    Catalytic activityi

    Uroporphyrinogen III = coproporphyrinogen + 4 CO2.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei103 – 1031SubstrateUniRule annotation
    Sitei103 – 1031Transition state stabilizerUniRule annotation
    Binding sitei178 – 1781SubstrateUniRule annotation
    Binding sitei233 – 2331SubstrateUniRule annotation
    Binding sitei347 – 3471SubstrateUniRule annotation

    GO - Molecular functioni

    1. uroporphyrinogen decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    DecarboxylaseUniRule annotationSAAS annotation, Lyase

    Keywords - Biological processi

    Porphyrin biosynthesisUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciRSAL288705:GHX1-1219-MONOMER.
    UniPathwayiUPA00251; UER00321.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uroporphyrinogen decarboxylaseUniRule annotation (EC:4.1.1.37UniRule annotation)
    Short name:
    UPDUniRule annotation
    Short name:
    URO-DUniRule annotation
    Gene namesi
    Name:hemEUniRule annotation
    Ordered Locus Names:RSal33209_1219Imported
    OrganismiRenibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)Imported
    Taxonomic identifieri288705 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeRenibacterium
    ProteomesiUP000002007: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi288705.RSal33209_1219.

    Structurei

    3D structure databases

    ProteinModelPortaliA9WPH2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni54 – 585Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the uroporphyrinogen decarboxylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0407.
    HOGENOMiHOG000253897.
    KOiK01599.
    OMAiEMVCEIT.
    OrthoDBiEOG6VXF6H.

    Family and domain databases

    HAMAPiMF_00218. URO_D.
    InterProiIPR006361. Uroporphyrinogen_deCO2ase_HemE.
    IPR000257. Uroporphyrinogen_deCOase.
    [Graphical view]
    PfamiPF01208. URO-D. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01464. hemE. 1 hit.
    PROSITEiPS00906. UROD_1. 1 hit.
    PS00907. UROD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9WPH2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTGCRYLSDE TTGRIEVMTL NSSHPLIDGR TTESPLIMAY SGKTPSRRPV    50
    WFMRQAGRSL PEYRKVREGI SMLDSCLKPD LASEITLQPV RRHDVDAAIF 100
    FSDIVIPLKL AGVGVDIVPG VGPVLEKPVR TLADVRALPK LTEDSLEPIR 150
    QAVALTVAEL GNTPLIGFAG APFTLAAYMV EGKPSRDHLG PRTMMHADPQ 200
    AWQELAAWAA DASGMFLRAQ LEAGASAAQL FDSWAGSLGL SDYQTHVAPA 250
    SKQALDHVRD LGAPLIHFGT GTSELLLAMR DVGVDVIGVD YRLPLDEANR 300
    RLGGMTPLQG NIDPALLPAP WPVLEAHILD VLRRGESAPG NVVNLGHGVP 350
    PETDPSVLSR IVELVHSVDP VRTDDQSA 378
    Length:378
    Mass (Da):40,693
    Last modified:February 5, 2008 - v1
    Checksum:i006FF70B2DF696E3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000910 Genomic DNA. Translation: ABY22957.1.
    RefSeqiWP_012244643.1. NC_010168.1.
    YP_001624371.1. NC_010168.1.

    Genome annotation databases

    EnsemblBacteriaiABY22957; ABY22957; RSal33209_1219.
    GeneIDi5822474.
    KEGGirsa:RSal33209_1219.
    PATRICi23075679. VBIRenSal21953_1260.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000910 Genomic DNA. Translation: ABY22957.1 .
    RefSeqi WP_012244643.1. NC_010168.1.
    YP_001624371.1. NC_010168.1.

    3D structure databases

    ProteinModelPortali A9WPH2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 288705.RSal33209_1219.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABY22957 ; ABY22957 ; RSal33209_1219 .
    GeneIDi 5822474.
    KEGGi rsa:RSal33209_1219.
    PATRICi 23075679. VBIRenSal21953_1260.

    Phylogenomic databases

    eggNOGi COG0407.
    HOGENOMi HOG000253897.
    KOi K01599.
    OMAi EMVCEIT.
    OrthoDBi EOG6VXF6H.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00321 .
    BioCyci RSAL288705:GHX1-1219-MONOMER.

    Family and domain databases

    HAMAPi MF_00218. URO_D.
    InterProi IPR006361. Uroporphyrinogen_deCO2ase_HemE.
    IPR000257. Uroporphyrinogen_deCOase.
    [Graphical view ]
    Pfami PF01208. URO-D. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01464. hemE. 1 hit.
    PROSITEi PS00906. UROD_1. 1 hit.
    PS00907. UROD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the fish pathogen Renibacterium salmoninarum suggests reductive evolution away from an environmental Arthrobacter ancestor."
      Wiens G.D., Rockey D.D., Wu Z., Chang J., Levy R., Crane S., Chen D.S., Capri G.R., Burnett J.R., Sudheesh P.S., Schipma M.J., Burd H., Bhattacharyya A., Rhodes L.D., Kaul R., Strom M.S.
      J. Bacteriol. 190:6970-6982(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235Imported.

    Entry informationi

    Entry nameiA9WPH2_RENSM
    AccessioniPrimary (citable) accession number: A9WPH2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3