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Protein

Uroporphyrinogen decarboxylase

Gene

hemE

Organism
Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.UniRule annotationSAAS annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

Uroporphyrinogen III = coproporphyrinogen + 4 CO2.UniRule annotationSAAS annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate.UniRule annotationSAAS annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Hydroxymethylbilane synthase (RSal33209_1223)
  3. no protein annotated in this organism
  4. Uroporphyrinogen decarboxylase (hemE)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei103SubstrateUniRule annotation1
Sitei103Transition state stabilizerUniRule annotation1
Binding sitei178SubstrateUniRule annotation1
Binding sitei233SubstrateUniRule annotation1
Binding sitei347SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylaseUniRule annotationSAAS annotation, Lyase
Biological processPorphyrin biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00251; UER00321

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen decarboxylaseUniRule annotationSAAS annotation (EC:4.1.1.37UniRule annotationSAAS annotation)
Short name:
UPDUniRule annotation
Short name:
URO-DUniRule annotation
Gene namesi
Name:hemEUniRule annotation
Ordered Locus Names:RSal33209_1219Imported
OrganismiRenibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)Imported
Taxonomic identifieri288705 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeRenibacterium
Proteomesi
  • UP000002007 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi288705.RSal33209_1219

Structurei

3D structure databases

ProteinModelPortaliA9WPH2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 58Uroporphyrinogen_deCOaseInterPro annotation10
Domaini166 – 182Uroporphyrinogen_deCOaseInterPro annotationAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni54 – 58Substrate bindingUniRule annotation5

Sequence similaritiesi

Belongs to the uroporphyrinogen decarboxylase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CFZ Bacteria
COG0407 LUCA
HOGENOMiHOG000253897
KOiK01599
OMAiSWAGQLS
OrthoDBiPOG091H040E

Family and domain databases

CDDicd00717 URO-D, 1 hit
Gene3Di3.20.20.210, 1 hit
HAMAPiMF_00218 URO_D, 1 hit
InterProiView protein in InterPro
IPR038071 UROD/MetE-like_sf
IPR006361 Uroporphyrinogen_deCO2ase_HemE
IPR000257 Uroporphyrinogen_deCOase
PfamiView protein in Pfam
PF01208 URO-D, 1 hit
SUPFAMiSSF51726 SSF51726, 1 hit
TIGRFAMsiTIGR01464 hemE, 1 hit
PROSITEiView protein in PROSITE
PS00906 UROD_1, 1 hit
PS00907 UROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

A9WPH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGCRYLSDE TTGRIEVMTL NSSHPLIDGR TTESPLIMAY SGKTPSRRPV
60 70 80 90 100
WFMRQAGRSL PEYRKVREGI SMLDSCLKPD LASEITLQPV RRHDVDAAIF
110 120 130 140 150
FSDIVIPLKL AGVGVDIVPG VGPVLEKPVR TLADVRALPK LTEDSLEPIR
160 170 180 190 200
QAVALTVAEL GNTPLIGFAG APFTLAAYMV EGKPSRDHLG PRTMMHADPQ
210 220 230 240 250
AWQELAAWAA DASGMFLRAQ LEAGASAAQL FDSWAGSLGL SDYQTHVAPA
260 270 280 290 300
SKQALDHVRD LGAPLIHFGT GTSELLLAMR DVGVDVIGVD YRLPLDEANR
310 320 330 340 350
RLGGMTPLQG NIDPALLPAP WPVLEAHILD VLRRGESAPG NVVNLGHGVP
360 370
PETDPSVLSR IVELVHSVDP VRTDDQSA
Length:378
Mass (Da):40,693
Last modified:February 5, 2008 - v1
Checksum:i006FF70B2DF696E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000910 Genomic DNA Translation: ABY22957.1

Genome annotation databases

EnsemblBacteriaiABY22957; ABY22957; RSal33209_1219
KEGGirsa:RSal33209_1219

Similar proteinsi

Entry informationi

Entry nameiA9WPH2_RENSM
AccessioniPrimary (citable) accession number: A9WPH2
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: March 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health