SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A9WPH2

- A9WPH2_RENSM

UniProt

A9WPH2 - A9WPH2_RENSM

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Uroporphyrinogen decarboxylase

Gene
hemE, RSal33209_1219
Organism
Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity.UniRule annotationSAAS annotations

Catalytic activityi

Uroporphyrinogen III = coproporphyrinogen + 4 CO2.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei103 – 1031Substrate By similarityUniRule annotation
Sitei103 – 1031Transition state stabilizer By similarityUniRule annotation
Binding sitei178 – 1781Substrate By similarityUniRule annotation
Binding sitei233 – 2331Substrate By similarityUniRule annotation
Binding sitei347 – 3471Substrate By similarityUniRule annotation

GO - Molecular functioni

  1. uroporphyrinogen decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotationSAAS annotations, Lyase

Keywords - Biological processi

Porphyrin biosynthesisUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciRSAL288705:GHX1-1219-MONOMER.
UniPathwayiUPA00251; UER00321.

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen decarboxylaseUniRule annotation (EC:4.1.1.37UniRule annotation)
Short name:
UPDUniRule annotation
Short name:
URO-DUniRule annotation
Gene namesi
Name:hemEUniRule annotation
Ordered Locus Names:RSal33209_1219Imported
OrganismiRenibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)Imported
Taxonomic identifieri288705 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeRenibacterium
ProteomesiUP000002007: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi288705.RSal33209_1219.

Structurei

3D structure databases

ProteinModelPortaliA9WPH2.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni54 – 585Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0407.
HOGENOMiHOG000253897.
KOiK01599.
OMAiEMVCEIT.
OrthoDBiEOG6VXF6H.

Family and domain databases

HAMAPiMF_00218. URO_D.
InterProiIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PfamiPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01464. hemE. 1 hit.
PROSITEiPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9WPH2-1 [UniParc]FASTAAdd to Basket

« Hide

MTGCRYLSDE TTGRIEVMTL NSSHPLIDGR TTESPLIMAY SGKTPSRRPV    50
WFMRQAGRSL PEYRKVREGI SMLDSCLKPD LASEITLQPV RRHDVDAAIF 100
FSDIVIPLKL AGVGVDIVPG VGPVLEKPVR TLADVRALPK LTEDSLEPIR 150
QAVALTVAEL GNTPLIGFAG APFTLAAYMV EGKPSRDHLG PRTMMHADPQ 200
AWQELAAWAA DASGMFLRAQ LEAGASAAQL FDSWAGSLGL SDYQTHVAPA 250
SKQALDHVRD LGAPLIHFGT GTSELLLAMR DVGVDVIGVD YRLPLDEANR 300
RLGGMTPLQG NIDPALLPAP WPVLEAHILD VLRRGESAPG NVVNLGHGVP 350
PETDPSVLSR IVELVHSVDP VRTDDQSA 378
Length:378
Mass (Da):40,693
Last modified:February 5, 2008 - v1
Checksum:i006FF70B2DF696E3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000910 Genomic DNA. Translation: ABY22957.1.
RefSeqiWP_012244643.1. NC_010168.1.
YP_001624371.1. NC_010168.1.

Genome annotation databases

EnsemblBacteriaiABY22957; ABY22957; RSal33209_1219.
GeneIDi5822474.
KEGGirsa:RSal33209_1219.
PATRICi23075679. VBIRenSal21953_1260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000910 Genomic DNA. Translation: ABY22957.1 .
RefSeqi WP_012244643.1. NC_010168.1.
YP_001624371.1. NC_010168.1.

3D structure databases

ProteinModelPortali A9WPH2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 288705.RSal33209_1219.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY22957 ; ABY22957 ; RSal33209_1219 .
GeneIDi 5822474.
KEGGi rsa:RSal33209_1219.
PATRICi 23075679. VBIRenSal21953_1260.

Phylogenomic databases

eggNOGi COG0407.
HOGENOMi HOG000253897.
KOi K01599.
OMAi EMVCEIT.
OrthoDBi EOG6VXF6H.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00321 .
BioCyci RSAL288705:GHX1-1219-MONOMER.

Family and domain databases

HAMAPi MF_00218. URO_D.
InterProi IPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view ]
Pfami PF01208. URO-D. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01464. hemE. 1 hit.
PROSITEi PS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the fish pathogen Renibacterium salmoninarum suggests reductive evolution away from an environmental Arthrobacter ancestor."
    Wiens G.D., Rockey D.D., Wu Z., Chang J., Levy R., Crane S., Chen D.S., Capri G.R., Burnett J.R., Sudheesh P.S., Schipma M.J., Burd H., Bhattacharyya A., Rhodes L.D., Kaul R., Strom M.S.
    J. Bacteriol. 190:6970-6982(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235.

Entry informationi

Entry nameiA9WPH2_RENSM
AccessioniPrimary (citable) accession number: A9WPH2
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 3, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi