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A9WPH2 (A9WPH2_RENSM) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase HAMAP-Rule MF_00218
Short name=UPD HAMAP-Rule MF_00218
Short name=URO-D HAMAP-Rule MF_00218
EC=4.1.1.37 HAMAP-Rule MF_00218
Gene names
Name:hemE HAMAP-Rule MF_00218
Ordered Locus Names:RSal33209_1219
OrganismRenibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235) [Complete proteome] [HAMAP] EMBL ABY22957.1
Taxonomic identifier288705 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Renibacterium ›

Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP-Rule MF_00218 SAAS SAAS006361

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP-Rule MF_00218 RuleBase RU000554 SAAS SAAS006361

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP-Rule MF_00218 RuleBase RU000554 SAAS SAAS006361

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00218 SAAS SAAS006361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00218 SAAS SAAS006361.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family. HAMAP-Rule MF_00218 RuleBase RU004169

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region54 – 585Substrate binding By similarity HAMAP-Rule MF_00218

Sites

Binding site1031Substrate By similarity HAMAP-Rule MF_00218
Binding site1781Substrate By similarity HAMAP-Rule MF_00218
Binding site2331Substrate By similarity HAMAP-Rule MF_00218
Binding site3471Substrate By similarity HAMAP-Rule MF_00218
Site1031Transition state stabilizer By similarity HAMAP-Rule MF_00218

Sequences

Sequence LengthMass (Da)Tools
A9WPH2 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 006FF70B2DF696E3

FASTA37840,693
        10         20         30         40         50         60 
MTGCRYLSDE TTGRIEVMTL NSSHPLIDGR TTESPLIMAY SGKTPSRRPV WFMRQAGRSL 

        70         80         90        100        110        120 
PEYRKVREGI SMLDSCLKPD LASEITLQPV RRHDVDAAIF FSDIVIPLKL AGVGVDIVPG 

       130        140        150        160        170        180 
VGPVLEKPVR TLADVRALPK LTEDSLEPIR QAVALTVAEL GNTPLIGFAG APFTLAAYMV 

       190        200        210        220        230        240 
EGKPSRDHLG PRTMMHADPQ AWQELAAWAA DASGMFLRAQ LEAGASAAQL FDSWAGSLGL 

       250        260        270        280        290        300 
SDYQTHVAPA SKQALDHVRD LGAPLIHFGT GTSELLLAMR DVGVDVIGVD YRLPLDEANR 

       310        320        330        340        350        360 
RLGGMTPLQG NIDPALLPAP WPVLEAHILD VLRRGESAPG NVVNLGHGVP PETDPSVLSR 

       370 
IVELVHSVDP VRTDDQSA

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References

[1]"Genome sequence of the fish pathogen Renibacterium salmoninarum suggests reductive evolution away from an environmental Arthrobacter ancestor."
Wiens G.D., Rockey D.D., Wu Z., Chang J., Levy R., Crane S., Chen D.S., Capri G.R., Burnett J.R., Sudheesh P.S., Schipma M.J., Burd H., Bhattacharyya A., Rhodes L.D., Kaul R., Strom M.S.
J. Bacteriol. 190:6970-6982(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000910 Genomic DNA. Translation: ABY22957.1.
RefSeqYP_001624371.1. NC_010168.1.

3D structure databases

ProteinModelPortalA9WPH2.
ModBaseSearch...

Protein-protein interaction databases

STRING288705.RSal33209_1219.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABY22957; ABY22957; RSal33209_1219.
GeneID5822474.
KEGGrsa:RSal33209_1219.
PATRIC23075679. VBIRenSal21953_1260.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0407.
HOGENOMHOG000253897.
KOK01599.
OMATLATYMI.
ProtClustDBPRK00115.

Enzyme and pathway databases

BioCycRSAL288705:GHX1-1219-MONOMER.
UniPathwayUPA00251; UER00321.

Family and domain databases

HAMAPMF_00218. URO_D.
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PANTHERPTHR21091:SF2. PTHR21091:SF2. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. hemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA9WPH2_RENSM
AccessionPrimary (citable) accession number: A9WPH2
Entry history
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: May 1, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info