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Protein

Uroporphyrinogen decarboxylase

Gene

hemE

Organism
Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.UniRule annotationSAAS annotation

Catalytic activityi

Uroporphyrinogen III = coproporphyrinogen + 4 CO2.UniRule annotationSAAS annotation

Pathway:iprotoporphyrin-IX biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate.UniRule annotationSAAS annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Hydroxymethylbilane synthase (RSal33209_1223)
  3. no protein annotated in this organism
  4. Uroporphyrinogen decarboxylase (hemE)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes coproporphyrinogen-III from 5-aminolevulinate, the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei103 – 1031SubstrateUniRule annotation
Sitei103 – 1031Transition state stabilizerUniRule annotation
Binding sitei178 – 1781SubstrateUniRule annotation
Binding sitei233 – 2331SubstrateUniRule annotation
Binding sitei347 – 3471SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Biological processi

Porphyrin biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciRSAL288705:GHX1-1219-MONOMER.
UniPathwayiUPA00251; UER00321.

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen decarboxylaseUniRule annotation (EC:4.1.1.37UniRule annotation)
Short name:
UPDUniRule annotation
Short name:
URO-DUniRule annotation
Gene namesi
Name:hemEUniRule annotation
Ordered Locus Names:RSal33209_1219Imported
OrganismiRenibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)Imported
Taxonomic identifieri288705 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeRenibacterium
ProteomesiUP000002007 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi288705.RSal33209_1219.

Structurei

3D structure databases

ProteinModelPortaliA9WPH2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni54 – 585Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the uroporphyrinogen decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0407.
HOGENOMiHOG000253897.
KOiK01599.
OMAiGSSKDFR.
OrthoDBiEOG6VXF6H.

Family and domain databases

HAMAPiMF_00218. URO_D.
InterProiIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PfamiPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01464. hemE. 1 hit.
PROSITEiPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9WPH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGCRYLSDE TTGRIEVMTL NSSHPLIDGR TTESPLIMAY SGKTPSRRPV
60 70 80 90 100
WFMRQAGRSL PEYRKVREGI SMLDSCLKPD LASEITLQPV RRHDVDAAIF
110 120 130 140 150
FSDIVIPLKL AGVGVDIVPG VGPVLEKPVR TLADVRALPK LTEDSLEPIR
160 170 180 190 200
QAVALTVAEL GNTPLIGFAG APFTLAAYMV EGKPSRDHLG PRTMMHADPQ
210 220 230 240 250
AWQELAAWAA DASGMFLRAQ LEAGASAAQL FDSWAGSLGL SDYQTHVAPA
260 270 280 290 300
SKQALDHVRD LGAPLIHFGT GTSELLLAMR DVGVDVIGVD YRLPLDEANR
310 320 330 340 350
RLGGMTPLQG NIDPALLPAP WPVLEAHILD VLRRGESAPG NVVNLGHGVP
360 370
PETDPSVLSR IVELVHSVDP VRTDDQSA
Length:378
Mass (Da):40,693
Last modified:February 5, 2008 - v1
Checksum:i006FF70B2DF696E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000910 Genomic DNA. Translation: ABY22957.1.
RefSeqiWP_012244643.1. NC_010168.1.

Genome annotation databases

EnsemblBacteriaiABY22957; ABY22957; RSal33209_1219.
KEGGirsa:RSal33209_1219.
PATRICi23075679. VBIRenSal21953_1260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000910 Genomic DNA. Translation: ABY22957.1.
RefSeqiWP_012244643.1. NC_010168.1.

3D structure databases

ProteinModelPortaliA9WPH2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi288705.RSal33209_1219.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABY22957; ABY22957; RSal33209_1219.
KEGGirsa:RSal33209_1219.
PATRICi23075679. VBIRenSal21953_1260.

Phylogenomic databases

eggNOGiCOG0407.
HOGENOMiHOG000253897.
KOiK01599.
OMAiGSSKDFR.
OrthoDBiEOG6VXF6H.

Enzyme and pathway databases

UniPathwayiUPA00251; UER00321.
BioCyciRSAL288705:GHX1-1219-MONOMER.

Family and domain databases

HAMAPiMF_00218. URO_D.
InterProiIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PfamiPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01464. hemE. 1 hit.
PROSITEiPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the fish pathogen Renibacterium salmoninarum suggests reductive evolution away from an environmental Arthrobacter ancestor."
    Wiens G.D., Rockey D.D., Wu Z., Chang J., Levy R., Crane S., Chen D.S., Capri G.R., Burnett J.R., Sudheesh P.S., Schipma M.J., Burd H., Bhattacharyya A., Rhodes L.D., Kaul R., Strom M.S.
    J. Bacteriol. 190:6970-6982(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235Imported.

Entry informationi

Entry nameiA9WPH2_RENSM
AccessioniPrimary (citable) accession number: A9WPH2
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: July 22, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.