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A9WP47

- TRMD_RENSM

UniProt

A9WP47 - TRMD_RENSM

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Protein

tRNA (guanine-N(1)-)-methyltransferase

Gene

trmD

Organism
Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Specifically methylates guanosine-37 in various tRNAs.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei113 – 1131S-adenosyl-L-methionine; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. tRNA (guanine(37)-N(1))-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciRSAL288705:GHX1-1084-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(1)-)-methyltransferaseUniRule annotation (EC:2.1.1.228UniRule annotation)
Alternative name(s):
M1G-methyltransferaseUniRule annotation
tRNA [GM37] methyltransferaseUniRule annotation
Gene namesi
Name:trmDUniRule annotation
Ordered Locus Names:RSal33209_1084
OrganismiRenibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)
Taxonomic identifieri288705 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeRenibacterium
ProteomesiUP000002007: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263tRNA (guanine-N(1)-)-methyltransferasePRO_1000082530Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi288705.RSal33209_1084.

Structurei

3D structure databases

ProteinModelPortaliA9WP47.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni137 – 1426S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the RNA methyltransferase TrmD family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0336.
HOGENOMiHOG000016242.
KOiK00554.
OMAiWRGHEVP.
OrthoDBiEOG6J48RZ.

Family and domain databases

Gene3Di1.10.1270.20. 1 hit.
3.40.1280.10. 1 hit.
HAMAPiMF_00605. TrmD.
InterProiIPR029028. Alpha/beta_knot_MTases.
IPR002649. tRNA_m1G_MeTrfase_bac.
IPR023148. tRNA_m1G_MeTrfase_C.
IPR029026. tRNA_m1G_MTases_N.
IPR016009. tRNA_MeTrfase_TRMD/TRM10.
[Graphical view]
PfamiPF01746. tRNA_m1G_MT. 1 hit.
[Graphical view]
PIRSFiPIRSF000386. tRNA_mtase. 1 hit.
SUPFAMiSSF75217. SSF75217. 1 hit.
TIGRFAMsiTIGR00088. trmD. 1 hit.

Sequencei

Sequence statusi: Complete.

A9WP47-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLDVISIFP DYLAPLELSL IGKARQDGLL ELNVHDLRAF TTDRHRTVDD
60 70 80 90 100
TPYGGGAGMV MKPEPWALAL ASVVEPAAKS KPVLIVPSPA GEVFNQRIAE
110 120 130 140 150
ELAAESHLVF ACGRYEGIDE RVVDWARESF TVRPMSLGDY VLNGGEVAVM
160 170 180 190 200
AMVEATARLL PGVVGNPDSL LEESHQDGLL EYPVYTKPSA WRGVDIPAVL
210 220 230 240 250
LSGNHAKIAR FRRDEQLRRT AQRRPDLLTQ LDPAILDRAD LAVLRESGYL
260
TVDGVLTRTS ELG
Length:263
Mass (Da):28,850
Last modified:February 5, 2008 - v1
Checksum:i49994713A46215AC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000910 Genomic DNA. Translation: ABY22822.1.
RefSeqiWP_012244511.1. NC_010168.1.
YP_001624236.1. NC_010168.1.

Genome annotation databases

EnsemblBacteriaiABY22822; ABY22822; RSal33209_1084.
GeneIDi5822172.
KEGGirsa:RSal33209_1084.
PATRICi23075387. VBIRenSal21953_1114.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000910 Genomic DNA. Translation: ABY22822.1 .
RefSeqi WP_012244511.1. NC_010168.1.
YP_001624236.1. NC_010168.1.

3D structure databases

ProteinModelPortali A9WP47.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 288705.RSal33209_1084.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY22822 ; ABY22822 ; RSal33209_1084 .
GeneIDi 5822172.
KEGGi rsa:RSal33209_1084.
PATRICi 23075387. VBIRenSal21953_1114.

Phylogenomic databases

eggNOGi COG0336.
HOGENOMi HOG000016242.
KOi K00554.
OMAi WRGHEVP.
OrthoDBi EOG6J48RZ.

Enzyme and pathway databases

BioCyci RSAL288705:GHX1-1084-MONOMER.

Family and domain databases

Gene3Di 1.10.1270.20. 1 hit.
3.40.1280.10. 1 hit.
HAMAPi MF_00605. TrmD.
InterProi IPR029028. Alpha/beta_knot_MTases.
IPR002649. tRNA_m1G_MeTrfase_bac.
IPR023148. tRNA_m1G_MeTrfase_C.
IPR029026. tRNA_m1G_MTases_N.
IPR016009. tRNA_MeTrfase_TRMD/TRM10.
[Graphical view ]
Pfami PF01746. tRNA_m1G_MT. 1 hit.
[Graphical view ]
PIRSFi PIRSF000386. tRNA_mtase. 1 hit.
SUPFAMi SSF75217. SSF75217. 1 hit.
TIGRFAMsi TIGR00088. trmD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the fish pathogen Renibacterium salmoninarum suggests reductive evolution away from an environmental Arthrobacter ancestor."
    Wiens G.D., Rockey D.D., Wu Z., Chang J., Levy R., Crane S., Chen D.S., Capri G.R., Burnett J.R., Sudheesh P.S., Schipma M.J., Burd H., Bhattacharyya A., Rhodes L.D., Kaul R., Strom M.S.
    J. Bacteriol. 190:6970-6982(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235.

Entry informationi

Entry nameiTRMD_RENSM
AccessioniPrimary (citable) accession number: A9WP47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3