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A9WP47

- TRMD_RENSM

UniProt

A9WP47 - TRMD_RENSM

Protein

tRNA (guanine-N(1)-)-methyltransferase

Gene

trmD

Organism
Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Specifically methylates guanosine-37 in various tRNAs.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei113 – 1131S-adenosyl-L-methionine; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine(37)-N(1))-methyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciRSAL288705:GHX1-1084-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(1)-)-methyltransferaseUniRule annotation (EC:2.1.1.228UniRule annotation)
    Alternative name(s):
    M1G-methyltransferaseUniRule annotation
    tRNA [GM37] methyltransferaseUniRule annotation
    Gene namesi
    Name:trmDUniRule annotation
    Ordered Locus Names:RSal33209_1084
    OrganismiRenibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)
    Taxonomic identifieri288705 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeRenibacterium
    ProteomesiUP000002007: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 263263tRNA (guanine-N(1)-)-methyltransferasePRO_1000082530Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi288705.RSal33209_1084.

    Structurei

    3D structure databases

    ProteinModelPortaliA9WP47.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni137 – 1426S-adenosyl-L-methionine bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the RNA methyltransferase TrmD family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0336.
    HOGENOMiHOG000016242.
    KOiK00554.
    OMAiWRGHEVP.
    OrthoDBiEOG6J48RZ.

    Family and domain databases

    Gene3Di1.10.1270.20. 1 hit.
    3.40.1280.10. 1 hit.
    HAMAPiMF_00605. TrmD.
    InterProiIPR029028. Alpha/beta_knot_MTases.
    IPR002649. tRNA_m1G_MeTrfase_bac.
    IPR023148. tRNA_m1G_MeTrfase_C.
    IPR029026. tRNA_m1G_MTases_N.
    IPR016009. tRNA_MeTrfase_TRMD/TRM10.
    [Graphical view]
    PfamiPF01746. tRNA_m1G_MT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000386. tRNA_mtase. 1 hit.
    SUPFAMiSSF75217. SSF75217. 1 hit.
    TIGRFAMsiTIGR00088. trmD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A9WP47-1 [UniParc]FASTAAdd to Basket

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    MRLDVISIFP DYLAPLELSL IGKARQDGLL ELNVHDLRAF TTDRHRTVDD    50
    TPYGGGAGMV MKPEPWALAL ASVVEPAAKS KPVLIVPSPA GEVFNQRIAE 100
    ELAAESHLVF ACGRYEGIDE RVVDWARESF TVRPMSLGDY VLNGGEVAVM 150
    AMVEATARLL PGVVGNPDSL LEESHQDGLL EYPVYTKPSA WRGVDIPAVL 200
    LSGNHAKIAR FRRDEQLRRT AQRRPDLLTQ LDPAILDRAD LAVLRESGYL 250
    TVDGVLTRTS ELG 263
    Length:263
    Mass (Da):28,850
    Last modified:February 5, 2008 - v1
    Checksum:i49994713A46215AC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000910 Genomic DNA. Translation: ABY22822.1.
    RefSeqiWP_012244511.1. NC_010168.1.
    YP_001624236.1. NC_010168.1.

    Genome annotation databases

    EnsemblBacteriaiABY22822; ABY22822; RSal33209_1084.
    GeneIDi5822172.
    KEGGirsa:RSal33209_1084.
    PATRICi23075387. VBIRenSal21953_1114.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000910 Genomic DNA. Translation: ABY22822.1 .
    RefSeqi WP_012244511.1. NC_010168.1.
    YP_001624236.1. NC_010168.1.

    3D structure databases

    ProteinModelPortali A9WP47.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 288705.RSal33209_1084.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABY22822 ; ABY22822 ; RSal33209_1084 .
    GeneIDi 5822172.
    KEGGi rsa:RSal33209_1084.
    PATRICi 23075387. VBIRenSal21953_1114.

    Phylogenomic databases

    eggNOGi COG0336.
    HOGENOMi HOG000016242.
    KOi K00554.
    OMAi WRGHEVP.
    OrthoDBi EOG6J48RZ.

    Enzyme and pathway databases

    BioCyci RSAL288705:GHX1-1084-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1270.20. 1 hit.
    3.40.1280.10. 1 hit.
    HAMAPi MF_00605. TrmD.
    InterProi IPR029028. Alpha/beta_knot_MTases.
    IPR002649. tRNA_m1G_MeTrfase_bac.
    IPR023148. tRNA_m1G_MeTrfase_C.
    IPR029026. tRNA_m1G_MTases_N.
    IPR016009. tRNA_MeTrfase_TRMD/TRM10.
    [Graphical view ]
    Pfami PF01746. tRNA_m1G_MT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000386. tRNA_mtase. 1 hit.
    SUPFAMi SSF75217. SSF75217. 1 hit.
    TIGRFAMsi TIGR00088. trmD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the fish pathogen Renibacterium salmoninarum suggests reductive evolution away from an environmental Arthrobacter ancestor."
      Wiens G.D., Rockey D.D., Wu Z., Chang J., Levy R., Crane S., Chen D.S., Capri G.R., Burnett J.R., Sudheesh P.S., Schipma M.J., Burd H., Bhattacharyya A., Rhodes L.D., Kaul R., Strom M.S.
      J. Bacteriol. 190:6970-6982(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235.

    Entry informationi

    Entry nameiTRMD_RENSM
    AccessioniPrimary (citable) accession number: A9WP47
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3