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Protein

Methionine--tRNA ligase

Gene

metG

Organism
Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.UniRule annotation

Catalytic activityi

ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationSAAS annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine--tRNA ligaseUniRule annotation (EC:6.1.1.10UniRule annotation)
Alternative name(s):
Methionyl-tRNA synthetaseUniRule annotation
Short name:
MetRSUniRule annotation
Gene namesi
Name:metGUniRule annotation
Ordered Locus Names:RSal33209_1051Imported
OrganismiRenibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)Imported
Taxonomic identifieri288705 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeRenibacterium
Proteomesi
  • UP000002007 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi288705.RSal33209_1051.

Structurei

3D structure databases

ProteinModelPortaliA9WP14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 368tRNA-synt_1gInterPro annotationAdd BLAST359

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi305 – 309"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKH. Bacteria.
COG0143. LUCA.
HOGENOMiHOG000200401.
KOiK01874.
OMAiTYVWFDA.
OrthoDBiPOG091H0269.

Family and domain databases

CDDicd00814. MetRS_core. 1 hit.
Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_01228. Met_tRNA_synth_type2. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR014758. Met-tRNA_synth.
IPR023457. Met-tRNA_synth_2.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR033911. MetRS_core.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
PfamiView protein in Pfam
PF09334. tRNA-synt_1g. 1 hit.
PRINTSiPR01041. TRNASYNTHMET.
SUPFAMiSSF47323. SSF47323. 1 hit.
TIGRFAMsiTIGR00398. metG. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

A9WP14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTESSNKRPY YLTTAITYPN GVPHIGHAYE YVSADALARF KRLDGFDVFY
60 70 80 90 100
MSGTDEHGIK VQQAAEKEGV TPLELVDRNS AAIRAVHDLV ESSYDRFIRT
110 120 130 140 150
TEPEHYLASQ ELWRRMEANG DIYLDKYTGW YSVRDEAYYT DEQTELRADG
160 170 180 190 200
IRYAIETETE VTWTEEESYF FRLSNYQEKL LALYEAQPEF AAPQYRFNEV
210 220 230 240 250
ISFVKSGLQD LSISRTSFNW GVPVPGNDKH VMYVWVDALT NYLTGAGFPD
260 270 280 290 300
ESSSQWKYWP ADVHIIGKDI SRFHAIFWPG FLMSAGLPLP KRVMIHGFLF
310 320 330 340 350
NNGVKMSKSF GNVVAPADWV AAYGVDAVRF FFLREVSYGQ DGNYSHEAII
360 370 380 390 400
SRKNSDLANN LGNLAQRSLS MVAKNCDGVV PTPGEFSSAD QAILAKAQAL
410 420 430 440 450
LAANRASYEV QEFHRALEAI WAVLGDTNAY FADQAPWVLR KTDPERMATV
460 470 480 490 500
LYVTLEVLRI VALLIQPVMP GSAAKLLDVL GVSAAEGARD FTAVETPLVA
510 520
GTALPAPSPI FPRYEEPAEA SAHGKPQTH
Length:529
Mass (Da):59,191
Last modified:February 5, 2008 - v1
Checksum:i30D9647955EA8BA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000910 Genomic DNA. Translation: ABY22789.1.
RefSeqiWP_012244480.1. NC_010168.1.

Genome annotation databases

EnsemblBacteriaiABY22789; ABY22789; RSal33209_1051.
KEGGirsa:RSal33209_1051.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000910 Genomic DNA. Translation: ABY22789.1.
RefSeqiWP_012244480.1. NC_010168.1.

3D structure databases

ProteinModelPortaliA9WP14.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi288705.RSal33209_1051.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABY22789; ABY22789; RSal33209_1051.
KEGGirsa:RSal33209_1051.

Phylogenomic databases

eggNOGiENOG4105CKH. Bacteria.
COG0143. LUCA.
HOGENOMiHOG000200401.
KOiK01874.
OMAiTYVWFDA.
OrthoDBiPOG091H0269.

Family and domain databases

CDDicd00814. MetRS_core. 1 hit.
Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_01228. Met_tRNA_synth_type2. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR014758. Met-tRNA_synth.
IPR023457. Met-tRNA_synth_2.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR033911. MetRS_core.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
PfamiView protein in Pfam
PF09334. tRNA-synt_1g. 1 hit.
PRINTSiPR01041. TRNASYNTHMET.
SUPFAMiSSF47323. SSF47323. 1 hit.
TIGRFAMsiTIGR00398. metG. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA9WP14_RENSM
AccessioniPrimary (citable) accession number: A9WP14
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: June 7, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.