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A9WP14

- A9WP14_RENSM

UniProt

A9WP14 - A9WP14_RENSM

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Protein
Methionine--tRNA ligase
Gene
metG, RSal33209_1051
Organism
Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).UniRule annotationSAAS annotations

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. methionine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. methionyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseUniRule annotationSAAS annotationsImported, Ligase

Keywords - Biological processi

Protein biosynthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciRSAL288705:GHX1-1051-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine--tRNA ligaseUniRule annotation (EC:6.1.1.10UniRule annotation)
Alternative name(s):
Methionyl-tRNA synthetase
Gene namesi
Name:metGUniRule annotation
Ordered Locus Names:RSal33209_1051Imported
OrganismiRenibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)Imported
Taxonomic identifieri288705 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeRenibacterium
ProteomesiUP000002007: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi288705.RSal33209_1051.

Structurei

3D structure databases

ProteinModelPortaliA9WP14.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi305 – 3095"KMSKS" region By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0143.
HOGENOMiHOG000200401.
KOiK01874.
OMAiTEVTWTE.
OrthoDBiEOG6CVV9B.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_01228. Met_tRNA_synth_type2.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR014758. Met-tRNA_synth.
IPR023457. Met-tRNA_synth_2.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PfamiPF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR01041. TRNASYNTHMET.
SUPFAMiSSF47323. SSF47323. 1 hit.
TIGRFAMsiTIGR00398. metG. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9WP14-1 [UniParc]FASTAAdd to Basket

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MTESSNKRPY YLTTAITYPN GVPHIGHAYE YVSADALARF KRLDGFDVFY    50
MSGTDEHGIK VQQAAEKEGV TPLELVDRNS AAIRAVHDLV ESSYDRFIRT 100
TEPEHYLASQ ELWRRMEANG DIYLDKYTGW YSVRDEAYYT DEQTELRADG 150
IRYAIETETE VTWTEEESYF FRLSNYQEKL LALYEAQPEF AAPQYRFNEV 200
ISFVKSGLQD LSISRTSFNW GVPVPGNDKH VMYVWVDALT NYLTGAGFPD 250
ESSSQWKYWP ADVHIIGKDI SRFHAIFWPG FLMSAGLPLP KRVMIHGFLF 300
NNGVKMSKSF GNVVAPADWV AAYGVDAVRF FFLREVSYGQ DGNYSHEAII 350
SRKNSDLANN LGNLAQRSLS MVAKNCDGVV PTPGEFSSAD QAILAKAQAL 400
LAANRASYEV QEFHRALEAI WAVLGDTNAY FADQAPWVLR KTDPERMATV 450
LYVTLEVLRI VALLIQPVMP GSAAKLLDVL GVSAAEGARD FTAVETPLVA 500
GTALPAPSPI FPRYEEPAEA SAHGKPQTH 529
Length:529
Mass (Da):59,191
Last modified:February 5, 2008 - v1
Checksum:i30D9647955EA8BA4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000910 Genomic DNA. Translation: ABY22789.1.
RefSeqiWP_012244480.1. NC_010168.1.
YP_001624203.1. NC_010168.1.

Genome annotation databases

EnsemblBacteriaiABY22789; ABY22789; RSal33209_1051.
GeneIDi5822139.
KEGGirsa:RSal33209_1051.
PATRICi23075311. VBIRenSal21953_1076.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000910 Genomic DNA. Translation: ABY22789.1 .
RefSeqi WP_012244480.1. NC_010168.1.
YP_001624203.1. NC_010168.1.

3D structure databases

ProteinModelPortali A9WP14.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 288705.RSal33209_1051.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY22789 ; ABY22789 ; RSal33209_1051 .
GeneIDi 5822139.
KEGGi rsa:RSal33209_1051.
PATRICi 23075311. VBIRenSal21953_1076.

Phylogenomic databases

eggNOGi COG0143.
HOGENOMi HOG000200401.
KOi K01874.
OMAi TEVTWTE.
OrthoDBi EOG6CVV9B.

Enzyme and pathway databases

BioCyci RSAL288705:GHX1-1051-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_01228. Met_tRNA_synth_type2.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR014758. Met-tRNA_synth.
IPR023457. Met-tRNA_synth_2.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view ]
Pfami PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR01041. TRNASYNTHMET.
SUPFAMi SSF47323. SSF47323. 1 hit.
TIGRFAMsi TIGR00398. metG. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the fish pathogen Renibacterium salmoninarum suggests reductive evolution away from an environmental Arthrobacter ancestor."
    Wiens G.D., Rockey D.D., Wu Z., Chang J., Levy R., Crane S., Chen D.S., Capri G.R., Burnett J.R., Sudheesh P.S., Schipma M.J., Burd H., Bhattacharyya A., Rhodes L.D., Kaul R., Strom M.S.
    J. Bacteriol. 190:6970-6982(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235.

Entry informationi

Entry nameiA9WP14_RENSM
AccessioniPrimary (citable) accession number: A9WP14
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 3, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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