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Protein

Methionine--tRNA ligase

Gene

metG

Organism
Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationSAAS annotationImported, Ligase
Biological processProtein biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciRSAL288705:G1GAP-912-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine--tRNA ligaseUniRule annotation (EC:6.1.1.10UniRule annotation)
Alternative name(s):
Methionyl-tRNA synthetaseUniRule annotation
Short name:
MetRSUniRule annotation
Gene namesi
Name:metGUniRule annotation
Ordered Locus Names:RSal33209_1051Imported
OrganismiRenibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)Imported
Taxonomic identifieri288705 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeRenibacterium
Proteomesi
  • UP000002007 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi288705.RSal33209_1051

Structurei

3D structure databases

ProteinModelPortaliA9WP14
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 368tRNA-synt_1gInterPro annotationAdd BLAST359

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi305 – 309"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKH Bacteria
COG0143 LUCA
HOGENOMiHOG000200401
KOiK01874
OMAiTYVWFDA
OrthoDBiPOG091H0269

Family and domain databases

CDDicd00814 MetRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_01228 Met_tRNA_synth_type2, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR014758 Met-tRNA_synth
IPR023457 Met-tRNA_synth_2
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR033911 MetRS_core
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
PfamiView protein in Pfam
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR01041 TRNASYNTHMET
SUPFAMiSSF47323 SSF47323, 1 hit
TIGRFAMsiTIGR00398 metG, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A9WP14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTESSNKRPY YLTTAITYPN GVPHIGHAYE YVSADALARF KRLDGFDVFY
60 70 80 90 100
MSGTDEHGIK VQQAAEKEGV TPLELVDRNS AAIRAVHDLV ESSYDRFIRT
110 120 130 140 150
TEPEHYLASQ ELWRRMEANG DIYLDKYTGW YSVRDEAYYT DEQTELRADG
160 170 180 190 200
IRYAIETETE VTWTEEESYF FRLSNYQEKL LALYEAQPEF AAPQYRFNEV
210 220 230 240 250
ISFVKSGLQD LSISRTSFNW GVPVPGNDKH VMYVWVDALT NYLTGAGFPD
260 270 280 290 300
ESSSQWKYWP ADVHIIGKDI SRFHAIFWPG FLMSAGLPLP KRVMIHGFLF
310 320 330 340 350
NNGVKMSKSF GNVVAPADWV AAYGVDAVRF FFLREVSYGQ DGNYSHEAII
360 370 380 390 400
SRKNSDLANN LGNLAQRSLS MVAKNCDGVV PTPGEFSSAD QAILAKAQAL
410 420 430 440 450
LAANRASYEV QEFHRALEAI WAVLGDTNAY FADQAPWVLR KTDPERMATV
460 470 480 490 500
LYVTLEVLRI VALLIQPVMP GSAAKLLDVL GVSAAEGARD FTAVETPLVA
510 520
GTALPAPSPI FPRYEEPAEA SAHGKPQTH
Length:529
Mass (Da):59,191
Last modified:February 5, 2008 - v1
Checksum:i30D9647955EA8BA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000910 Genomic DNA Translation: ABY22789.1
RefSeqiWP_012244480.1, NC_010168.1

Genome annotation databases

EnsemblBacteriaiABY22789; ABY22789; RSal33209_1051
KEGGirsa:RSal33209_1051

Similar proteinsi

Entry informationi

Entry nameiA9WP14_RENSM
AccessioniPrimary (citable) accession number: A9WP14
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: March 28, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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