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A9WP14 (A9WP14_RENSM) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Methionine--tRNA ligase HAMAP-Rule MF_01228
EC=6.1.1.10 HAMAP-Rule MF_01228
Alternative name(s):
Methionyl-tRNA synthetase HAMAP-Rule MF_01228
Gene names
Name:metG HAMAP-Rule MF_01228
Ordered Locus Names:RSal33209_1051
OrganismRenibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235) [Complete proteome] [HAMAP] EMBL ABY22789.1
Taxonomic identifier288705 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Renibacterium ›

Protein attributes

Sequence length529 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation By similarity. HAMAP-Rule MF_01228

Catalytic activity

ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met). HAMAP-Rule MF_01228 SAAS SAAS023457

Subunit structure

Monomer By similarity. HAMAP-Rule MF_01228

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01228.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. HAMAP-Rule MF_01228

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Motif305 – 3095"KMSKS" region By similarity HAMAP-Rule MF_01228

Sequences

Sequence LengthMass (Da)Tools
A9WP14 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: 30D9647955EA8BA4

FASTA52959,191
        10         20         30         40         50         60 
MTESSNKRPY YLTTAITYPN GVPHIGHAYE YVSADALARF KRLDGFDVFY MSGTDEHGIK 

        70         80         90        100        110        120 
VQQAAEKEGV TPLELVDRNS AAIRAVHDLV ESSYDRFIRT TEPEHYLASQ ELWRRMEANG 

       130        140        150        160        170        180 
DIYLDKYTGW YSVRDEAYYT DEQTELRADG IRYAIETETE VTWTEEESYF FRLSNYQEKL 

       190        200        210        220        230        240 
LALYEAQPEF AAPQYRFNEV ISFVKSGLQD LSISRTSFNW GVPVPGNDKH VMYVWVDALT 

       250        260        270        280        290        300 
NYLTGAGFPD ESSSQWKYWP ADVHIIGKDI SRFHAIFWPG FLMSAGLPLP KRVMIHGFLF 

       310        320        330        340        350        360 
NNGVKMSKSF GNVVAPADWV AAYGVDAVRF FFLREVSYGQ DGNYSHEAII SRKNSDLANN 

       370        380        390        400        410        420 
LGNLAQRSLS MVAKNCDGVV PTPGEFSSAD QAILAKAQAL LAANRASYEV QEFHRALEAI 

       430        440        450        460        470        480 
WAVLGDTNAY FADQAPWVLR KTDPERMATV LYVTLEVLRI VALLIQPVMP GSAAKLLDVL 

       490        500        510        520 
GVSAAEGARD FTAVETPLVA GTALPAPSPI FPRYEEPAEA SAHGKPQTH

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References

[1]"Genome sequence of the fish pathogen Renibacterium salmoninarum suggests reductive evolution away from an environmental Arthrobacter ancestor."
Wiens G.D., Rockey D.D., Wu Z., Chang J., Levy R., Crane S., Chen D.S., Capri G.R., Burnett J.R., Sudheesh P.S., Schipma M.J., Burd H., Bhattacharyya A., Rhodes L.D., Kaul R., Strom M.S.
J. Bacteriol. 190:6970-6982(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000910 Genomic DNA. Translation: ABY22789.1.
RefSeqYP_001624203.1. NC_010168.1.

3D structure databases

ProteinModelPortalA9WP14.
ModBaseSearch...

Protein-protein interaction databases

STRING288705.RSal33209_1051.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABY22789; ABY22789; RSal33209_1051.
GeneID5822139.
KEGGrsa:RSal33209_1051.
PATRIC23075311. VBIRenSal21953_1076.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0143.
HOGENOMHOG000200401.
KOK01874.
OMARINYDLA.
ProtClustDBPRK11893.

Enzyme and pathway databases

BioCycRSAL288705:GHX1-1051-MONOMER.

Family and domain databases

Gene3D3.40.50.620. 2 hits.
HAMAPMF_01228. Met_tRNA_synth_type2.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR014758. Met-tRNA_synth.
IPR023457. Met-tRNA_synth_2.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PfamPF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR01041. TRNASYNTHMET.
SUPFAMSSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMsTIGR00398. metG. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA9WP14_RENSM
AccessionPrimary (citable) accession number: A9WP14
Entry history
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: May 1, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info