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A9WMW3

- FTHS_RENSM

UniProt

A9WMW3 - FTHS_RENSM

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, RSal33209_1710
Organism
Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi69 – 768ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRSAL288705:GHX1-1710-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:RSal33209_1710
OrganismiRenibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)
Taxonomic identifieri288705 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeRenibacterium
ProteomesiUP000002007: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 564564Formate--tetrahydrofolate ligaseUniRule annotationPRO_0000333316Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi288705.RSal33209_1710.

Structurei

3D structure databases

ProteinModelPortaliA9WMW3.
SMRiA9WMW3. Positions 10-562.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiTWRRCLD.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9WMW3-1 [UniParc]FASTAAdd to Basket

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MTSTTEPMTD LHIAQQAVLH PIFDIADAAG IPEEALEQYG RYKAKVDVRK    50
VPDSGRAGRV VLVTAVSPTP AGEGKSTTTV GLADSLNRAF EQEGTGRRSM 100
IALREPSLGP TLGMKGGATG GGYSQVLPMD EINLHFTGDL HAINSANNAL 150
CALIDNHIYQ GNVLNIDPRR ITFKRVLDMN DRALREVVIG LGGPTQGVPR 200
QDGFDITVAS EIMAVFCLAT DLNDLKSRIG KITFGYNYDR QPLTVAGLGV 250
EGVLTLLLKE AIKPNLVQTL AGTAALVHGG PFANIAHGCN SVIATSLARR 300
RADVVVTEAG FGADLGAEKY MDIKSRFADV APSAVVIVAT IRALKMHGGV 350
PKTELSVSDV AALRRGVTNL ARHISNVRQF GLDPVVSINR FTSDSEEELD 400
WLVSWCESQG VSIAIADVWG RGGGGDDLAA KVLAALDAPS DFRHLYELEL 450
PVKEKIELIA QKIYGAERVE FSSSALKRIA EISANGWDSL PVCMAKTQYS 500
FSDDASLLGA PSGFVLHVRD LVPKTGAGFI VALTGAVMTM PGLPKQPAAL 550
KMDVDAEGNS VGLS 564
Length:564
Mass (Da):59,860
Last modified:February 5, 2008 - v1
Checksum:iDC6559FB43FE7A3D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000910 Genomic DNA. Translation: ABY23446.1.
RefSeqiYP_001624860.1. NC_010168.1.

Genome annotation databases

EnsemblBacteriaiABY23446; ABY23446; RSal33209_1710.
GeneIDi5822435.
KEGGirsa:RSal33209_1710.
PATRICi23076715. VBIRenSal21953_1777.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000910 Genomic DNA. Translation: ABY23446.1 .
RefSeqi YP_001624860.1. NC_010168.1.

3D structure databases

ProteinModelPortali A9WMW3.
SMRi A9WMW3. Positions 10-562.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 288705.RSal33209_1710.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY23446 ; ABY23446 ; RSal33209_1710 .
GeneIDi 5822435.
KEGGi rsa:RSal33209_1710.
PATRICi 23076715. VBIRenSal21953_1777.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi TWRRCLD.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci RSAL288705:GHX1-1710-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the fish pathogen Renibacterium salmoninarum suggests reductive evolution away from an environmental Arthrobacter ancestor."
    Wiens G.D., Rockey D.D., Wu Z., Chang J., Levy R., Crane S., Chen D.S., Capri G.R., Burnett J.R., Sudheesh P.S., Schipma M.J., Burd H., Bhattacharyya A., Rhodes L.D., Kaul R., Strom M.S.
    J. Bacteriol. 190:6970-6982(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235.

Entry informationi

Entry nameiFTHS_RENSM
AccessioniPrimary (citable) accession number: A9WMW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 5, 2008
Last modified: May 14, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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