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A9WMW3

- FTHS_RENSM

UniProt

A9WMW3 - FTHS_RENSM

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi69 – 768ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRSAL288705:GHX1-1710-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:RSal33209_1710
    OrganismiRenibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)
    Taxonomic identifieri288705 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeRenibacterium
    ProteomesiUP000002007: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 564564Formate--tetrahydrofolate ligasePRO_0000333316Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi288705.RSal33209_1710.

    Structurei

    3D structure databases

    ProteinModelPortaliA9WMW3.
    SMRiA9WMW3. Positions 10-562.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiTWRRCLD.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9WMW3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSTTEPMTD LHIAQQAVLH PIFDIADAAG IPEEALEQYG RYKAKVDVRK    50
    VPDSGRAGRV VLVTAVSPTP AGEGKSTTTV GLADSLNRAF EQEGTGRRSM 100
    IALREPSLGP TLGMKGGATG GGYSQVLPMD EINLHFTGDL HAINSANNAL 150
    CALIDNHIYQ GNVLNIDPRR ITFKRVLDMN DRALREVVIG LGGPTQGVPR 200
    QDGFDITVAS EIMAVFCLAT DLNDLKSRIG KITFGYNYDR QPLTVAGLGV 250
    EGVLTLLLKE AIKPNLVQTL AGTAALVHGG PFANIAHGCN SVIATSLARR 300
    RADVVVTEAG FGADLGAEKY MDIKSRFADV APSAVVIVAT IRALKMHGGV 350
    PKTELSVSDV AALRRGVTNL ARHISNVRQF GLDPVVSINR FTSDSEEELD 400
    WLVSWCESQG VSIAIADVWG RGGGGDDLAA KVLAALDAPS DFRHLYELEL 450
    PVKEKIELIA QKIYGAERVE FSSSALKRIA EISANGWDSL PVCMAKTQYS 500
    FSDDASLLGA PSGFVLHVRD LVPKTGAGFI VALTGAVMTM PGLPKQPAAL 550
    KMDVDAEGNS VGLS 564
    Length:564
    Mass (Da):59,860
    Last modified:February 5, 2008 - v1
    Checksum:iDC6559FB43FE7A3D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000910 Genomic DNA. Translation: ABY23446.1.
    RefSeqiYP_001624860.1. NC_010168.1.

    Genome annotation databases

    EnsemblBacteriaiABY23446; ABY23446; RSal33209_1710.
    GeneIDi5822435.
    KEGGirsa:RSal33209_1710.
    PATRICi23076715. VBIRenSal21953_1777.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000910 Genomic DNA. Translation: ABY23446.1 .
    RefSeqi YP_001624860.1. NC_010168.1.

    3D structure databases

    ProteinModelPortali A9WMW3.
    SMRi A9WMW3. Positions 10-562.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 288705.RSal33209_1710.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABY23446 ; ABY23446 ; RSal33209_1710 .
    GeneIDi 5822435.
    KEGGi rsa:RSal33209_1710.
    PATRICi 23076715. VBIRenSal21953_1777.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi TWRRCLD.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci RSAL288705:GHX1-1710-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the fish pathogen Renibacterium salmoninarum suggests reductive evolution away from an environmental Arthrobacter ancestor."
      Wiens G.D., Rockey D.D., Wu Z., Chang J., Levy R., Crane S., Chen D.S., Capri G.R., Burnett J.R., Sudheesh P.S., Schipma M.J., Burd H., Bhattacharyya A., Rhodes L.D., Kaul R., Strom M.S.
      J. Bacteriol. 190:6970-6982(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235.

    Entry informationi

    Entry nameiFTHS_RENSM
    AccessioniPrimary (citable) accession number: A9WMW3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3