A9WME5 (A9WME5_RENSM) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Aminomethyltransferase HAMAP MF_00259
EC=2.1.2.10 HAMAP MF_00259

Alternative name(s):
Glycine cleavage system T protein HAMAP MF_00259

Gene names

Name:	gcvT HAMAP MF_00259
Ordered Locus Names:	RSal33209_1722

Organism

Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235) [Complete proteome] [HAMAP] EMBL ABY23458.1

Taxonomic identifier

288705 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Renibacterium

Protein attributes

Sequence length	382 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity. HAMAP MF_00259
Sequence similarities	Belongs to the GcvT family. HAMAP MF_00259

Ontologies

Keywords
Molecular function	Aminotransferase HAMAP MF_00259 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: HAMAP transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A9WME5 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 7818015E8DE7A7BD	FASTA	382	40,810
	10 20 30 40 50 60 MTLKETALQA EHAKLGASFT DFGGWDMPLK YQSELAEHHA VRQGAGLFDL SHMGEIWVRG 70 80 90 100 110 120 AQAAAFLDYA LVGNLSAIQV GKAKYSLICT PDGGIIDDLI SYRRAEDVYL VVPNAGNADA 130 140 150 160 170 180 VYAEFVKRAE GFDVELDNVS AQTSLIALQG PEAERILLGL VPAEQAEAVR ELKYYAATEV 190 200 210 220 230 240 TVSGLPILLA RTGYTGEDGF ELYIDNSEAA QLWNSLLTAD EVVTPCGLAS RDSLRLEAAM 250 260 270 280 290 300 PLYGNELGLD GNPFEAGLGP VVSLAPAKTA KEGDFVGKEA LAKIKAERAQ TPEGQSVTGK 310 320 330 340 350 360 RILVGLQGQG RRAARGHYPV VLNGETVGEV TSGLPSPTLG YPVALAYVNA EHSEVGTELQ 370 380 VDLRGKTEPF TVVALPFYKR TK

References

[1]

"Genome sequence of the fish pathogen Renibacterium salmoninarum suggests reductive evolution away from an environmental Arthrobacter ancestor." Wiens G.D., Rockey D.D., Wu Z., Chang J., Levy R., Crane S., Chen D.S., Capri G.R., Burnett J.R., Sudheesh P.S., Schipma M.J., Burd H., Bhattacharyya A., Rhodes L.D., Kaul R., Strom M.S. J. Bacteriol. 190:6970-6982(2008) [PubMed: 18723615] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000910 Genomic DNA. Translation: ABY23458.1.
RefSeq	YP_001624872.1. NC_010168.1.
3D structure databases
ProteinModelPortal	A9WME5.
ModBase	Search...
Protein-protein interaction databases
STRING	A9WME5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5822447.
GenomeReviews	Gene locus RSal33209_1722 in contig CP000910_GR.
KEGG	rsa:RSal33209_1722.
PATRIC	23076739. VBIRenSal21953_1789.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG299834.
OMA	KALYGGM.
ProtClustDB	PRK00389.
Enzyme and pathway databases
BioCyc	RSAL288705:RSAL33209_1722-MONOMER.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A9WME5_RENSM

Accession

Primary (citable) accession number: A9WME5

Entry history

Integrated into UniProtKB/TrEMBL:	February 5, 2008
Last sequence update:	February 5, 2008
Last modified:	December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)