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Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene

gpmA

Organism
Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotationSAAS annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotationSAAS annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (RSal33209_2327)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei16Tele-phosphohistidine intermediateUniRule annotation1
Binding sitei67SubstrateUniRule annotation1
Active sitei94Proton donor/acceptorUniRule annotation1
Binding sitei105SubstrateUniRule annotation1
Sitei188Transition state stabilizerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationImported

Keywords - Biological processi

GluconeogenesisUniRule annotationSAAS annotation, GlycolysisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation)
Short name:
BPG-dependent PGAMUniRule annotation
Short name:
PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
dPGMUniRule annotation
Gene namesi
Name:gpmAUniRule annotation
Ordered Locus Names:RSal33209_0404Imported
OrganismiRenibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)Imported
Taxonomic identifieri288705 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeRenibacterium
Proteomesi
  • UP000002007 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi288705.RSal33209_0404.

Structurei

3D structure databases

ProteinModelPortaliA9WLX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni15 – 22Substrate bindingUniRule annotation8
Regioni28 – 29Substrate bindingUniRule annotation2
Regioni94 – 97Substrate bindingUniRule annotation4
Regioni121 – 122Substrate bindingUniRule annotation2
Regioni189 – 190Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4107RPC. Bacteria.
COG0588. LUCA.
HOGENOMiHOG000221682.
KOiK01834.
OMAiVKNQGKK.
OrthoDBiPOG091H03E2.

Family and domain databases

CDDicd07067. HP_PGM_like. 1 hit.
Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA. 1 hit.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR005952. Phosphogly_mut1.
[Graphical view]
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiPF00300. His_Phos_1. 2 hits.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.

Sequencei

Sequence statusi: Complete.

A9WLX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRLLDMTYT LILLRHGHSE WNAKNLFTGW VDVDLNDQGR AEAVRGGQLL
60 70 80 90 100
VENDLLPDVL YTSRQKRAIN TANLTLAEAD RGWIDVKRSW RLNERHYGAL
110 120 130 140 150
QGKDKAQTLA EFGEAQFMEW RRSYDVPPPP LPDDSEFSQV GDPRYADLGD
160 170 180 190 200
AIPRTECLKD VLERLLSYWE SDIKADLCAG KTVLVTAHGN SLRSLVKHLD
210 220 230 240 250
GISDEAIAGL NIPTGIPLVY ELDENFAPIT AGGRYLDPAA AAAIQAVANQ

GKK
Length:253
Mass (Da):28,113
Last modified:February 5, 2008 - v1
Checksum:i5CC534C4CFBF5643
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000910 Genomic DNA. Translation: ABY22158.1.

Genome annotation databases

EnsemblBacteriaiABY22158; ABY22158; RSal33209_0404.
KEGGirsa:RSal33209_0404.
PATRICi23073960. VBIRenSal21953_0417.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000910 Genomic DNA. Translation: ABY22158.1.

3D structure databases

ProteinModelPortaliA9WLX7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi288705.RSal33209_0404.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABY22158; ABY22158; RSal33209_0404.
KEGGirsa:RSal33209_0404.
PATRICi23073960. VBIRenSal21953_0417.

Phylogenomic databases

eggNOGiENOG4107RPC. Bacteria.
COG0588. LUCA.
HOGENOMiHOG000221682.
KOiK01834.
OMAiVKNQGKK.
OrthoDBiPOG091H03E2.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.

Family and domain databases

CDDicd07067. HP_PGM_like. 1 hit.
Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA. 1 hit.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR005952. Phosphogly_mut1.
[Graphical view]
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiPF00300. His_Phos_1. 2 hits.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA9WLX7_RENSM
AccessioniPrimary (citable) accession number: A9WLX7
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 30, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.