Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A9WLT6

- A9WLT6_RENSM

UniProt

A9WLT6 - A9WLT6_RENSM

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Isocitrate dehydrogenase [NADP]

Gene

RSal33209_0245

Organism
Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei88 – 881SubstrateUniRule annotation
Binding sitei93 – 931NADPUniRule annotation
Binding sitei120 – 1201SubstrateUniRule annotation
Binding sitei143 – 1431SubstrateUniRule annotation
Sitei223 – 2231Critical for catalysisUniRule annotation
Metal bindingi263 – 2631Magnesium or manganeseUniRule annotation
Binding sitei271 – 2711NADPUniRule annotation
Metal bindingi286 – 2861Magnesium or manganeseUniRule annotation
Binding sitei339 – 3391NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi86 – 883NADPUniRule annotation
Nucleotide bindingi321 – 3266NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciRSAL288705:GHX1-245-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:RSal33209_0245Imported
OrganismiRenibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)Imported
Taxonomic identifieri288705 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeRenibacterium
ProteomesiUP000002007: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi288705.RSal33209_0245.

Structurei

3D structure databases

ProteinModelPortaliA9WLT6.
SMRiA9WLT6. Positions 19-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni105 – 1117Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000019858.
KOiK00031.
OMAiFKDEFQR.
OrthoDBiEOG628F3X.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9WLT6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRRTVVSEGS VAYKIKVVGP VVELDGDEMT RIIWKFIKDR LIHPYLDIDL
60 70 80 90 100
RYYDLSIQNR DATDDQVTID AANAIKEHHV GVKCATITPD EARVEEFGLK
110 120 130 140 150
KMWVSPNGTI RNILGGVVFR EPIIISNIPR LVPGWNKPII IGRHAFGDQY
160 170 180 190 200
RATNFKVPGP GKLTMSFEPA DGSEPMKFDV VSYPEAGGVA MGMYNFTDSI
210 220 230 240 250
KDFARASFAY GLQRNYPVYL STKNTILKAY DGQFKDLFQE IFDNEFKDQF
260 270 280 290 300
DAAGLTYEHR LIDDMVASAM KWEGGYVWAC KNYDGDVQSD TVAQGFGSLG
310 320 330 340 350
LMTSVLMTPD GQTVEAEAAH GTVTRHYRQH QQGKPTSTNP IASIFAWTRG
360 370 380 390 400
LMHRGKIDNT PEVIEFAETL EDVVIKTVES GKMTKDLALL VSQDQAFLTT
410
EDFLAALDEN LSARLAG
Length:417
Mass (Da):46,532
Last modified:February 5, 2008 - v1
Checksum:iDEDFC97F51E621E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000910 Genomic DNA. Translation: ABY22001.1.
RefSeqiWP_012243709.1. NC_010168.1.
YP_001623415.1. NC_010168.1.

Genome annotation databases

EnsemblBacteriaiABY22001; ABY22001; RSal33209_0245.
GeneIDi5823479.
KEGGirsa:RSal33209_0245.
PATRICi23073618. VBIRenSal21953_0248.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000910 Genomic DNA. Translation: ABY22001.1 .
RefSeqi WP_012243709.1. NC_010168.1.
YP_001623415.1. NC_010168.1.

3D structure databases

ProteinModelPortali A9WLT6.
SMRi A9WLT6. Positions 19-416.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 288705.RSal33209_0245.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY22001 ; ABY22001 ; RSal33209_0245 .
GeneIDi 5823479.
KEGGi rsa:RSal33209_0245.
PATRICi 23073618. VBIRenSal21953_0248.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000019858.
KOi K00031.
OMAi FKDEFQR.
OrthoDBi EOG628F3X.

Enzyme and pathway databases

BioCyci RSAL288705:GHX1-245-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the fish pathogen Renibacterium salmoninarum suggests reductive evolution away from an environmental Arthrobacter ancestor."
    Wiens G.D., Rockey D.D., Wu Z., Chang J., Levy R., Crane S., Chen D.S., Capri G.R., Burnett J.R., Sudheesh P.S., Schipma M.J., Burd H., Bhattacharyya A., Rhodes L.D., Kaul R., Strom M.S.
    J. Bacteriol. 190:6970-6982(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235Imported.

Entry informationi

Entry nameiA9WLT6_RENSM
AccessioniPrimary (citable) accession number: A9WLT6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 26, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3