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A9WLT6 (A9WLT6_RENSM) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding86 – 883NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding321 – 3266NADP By similarity PIRSR PIRSR000108-4
Region105 – 1117Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2631Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2861Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site881Substrate By similarity PIRSR PIRSR000108-2
Binding site931NADP By similarity PIRSR PIRSR000108-4
Binding site1201Substrate By similarity PIRSR PIRSR000108-2
Binding site1431Substrate By similarity PIRSR PIRSR000108-2
Binding site2711NADP By similarity PIRSR PIRSR000108-4
Binding site3391NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1501Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2231Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
A9WLT6 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: DEDFC97F51E621E2

FASTA41746,532
        10         20         30         40         50         60 
MRRTVVSEGS VAYKIKVVGP VVELDGDEMT RIIWKFIKDR LIHPYLDIDL RYYDLSIQNR 

        70         80         90        100        110        120 
DATDDQVTID AANAIKEHHV GVKCATITPD EARVEEFGLK KMWVSPNGTI RNILGGVVFR 

       130        140        150        160        170        180 
EPIIISNIPR LVPGWNKPII IGRHAFGDQY RATNFKVPGP GKLTMSFEPA DGSEPMKFDV 

       190        200        210        220        230        240 
VSYPEAGGVA MGMYNFTDSI KDFARASFAY GLQRNYPVYL STKNTILKAY DGQFKDLFQE 

       250        260        270        280        290        300 
IFDNEFKDQF DAAGLTYEHR LIDDMVASAM KWEGGYVWAC KNYDGDVQSD TVAQGFGSLG 

       310        320        330        340        350        360 
LMTSVLMTPD GQTVEAEAAH GTVTRHYRQH QQGKPTSTNP IASIFAWTRG LMHRGKIDNT 

       370        380        390        400        410 
PEVIEFAETL EDVVIKTVES GKMTKDLALL VSQDQAFLTT EDFLAALDEN LSARLAG 

« Hide

References

[1]"Genome sequence of the fish pathogen Renibacterium salmoninarum suggests reductive evolution away from an environmental Arthrobacter ancestor."
Wiens G.D., Rockey D.D., Wu Z., Chang J., Levy R., Crane S., Chen D.S., Capri G.R., Burnett J.R., Sudheesh P.S., Schipma M.J., Burd H., Bhattacharyya A., Rhodes L.D., Kaul R., Strom M.S.
J. Bacteriol. 190:6970-6982(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000910 Genomic DNA. Translation: ABY22001.1.
RefSeqYP_001623415.1. NC_010168.1.

3D structure databases

ProteinModelPortalA9WLT6.
SMRA9WLT6. Positions 19-416.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING288705.RSal33209_0245.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABY22001; ABY22001; RSal33209_0245.
GeneID5823479.
KEGGrsa:RSal33209_0245.
PATRIC23073618. VBIRenSal21953_0248.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0538.
HOGENOMHOG000019858.
KOK00031.
OMAQHQQGKP.
OrthoDBEOG628F3X.
ProtClustDBPRK08299.

Enzyme and pathway databases

BioCycRSAL288705:GHX1-245-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA9WLT6_RENSM
AccessionPrimary (citable) accession number: A9WLT6
Entry history
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: February 19, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)