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A9WLT6

- A9WLT6_RENSM

UniProt

A9WLT6 - A9WLT6_RENSM

Protein

Isocitrate dehydrogenase [NADP]

Gene

RSal33209_0245

Organism
Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei88 – 881SubstrateUniRule annotation
    Binding sitei93 – 931NADPUniRule annotation
    Binding sitei120 – 1201SubstrateUniRule annotation
    Binding sitei143 – 1431SubstrateUniRule annotation
    Sitei150 – 1501Critical for catalysis
    Sitei223 – 2231Critical for catalysisUniRule annotation
    Metal bindingi263 – 2631Magnesium or manganeseUniRule annotation
    Binding sitei271 – 2711NADPUniRule annotation
    Metal bindingi286 – 2861Magnesium or manganeseUniRule annotation
    Binding sitei339 – 3391NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi86 – 883NADPUniRule annotation
    Nucleotide bindingi321 – 3266NADPUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciRSAL288705:GHX1-245-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:RSal33209_0245Imported
    OrganismiRenibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)Imported
    Taxonomic identifieri288705 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrococcaceaeRenibacterium
    ProteomesiUP000002007: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi288705.RSal33209_0245.

    Structurei

    3D structure databases

    ProteinModelPortaliA9WLT6.
    SMRiA9WLT6. Positions 19-416.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni105 – 1117Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0538.
    HOGENOMiHOG000019858.
    KOiK00031.
    OMAiFKDEFQR.
    OrthoDBiEOG628F3X.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A9WLT6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRRTVVSEGS VAYKIKVVGP VVELDGDEMT RIIWKFIKDR LIHPYLDIDL    50
    RYYDLSIQNR DATDDQVTID AANAIKEHHV GVKCATITPD EARVEEFGLK 100
    KMWVSPNGTI RNILGGVVFR EPIIISNIPR LVPGWNKPII IGRHAFGDQY 150
    RATNFKVPGP GKLTMSFEPA DGSEPMKFDV VSYPEAGGVA MGMYNFTDSI 200
    KDFARASFAY GLQRNYPVYL STKNTILKAY DGQFKDLFQE IFDNEFKDQF 250
    DAAGLTYEHR LIDDMVASAM KWEGGYVWAC KNYDGDVQSD TVAQGFGSLG 300
    LMTSVLMTPD GQTVEAEAAH GTVTRHYRQH QQGKPTSTNP IASIFAWTRG 350
    LMHRGKIDNT PEVIEFAETL EDVVIKTVES GKMTKDLALL VSQDQAFLTT 400
    EDFLAALDEN LSARLAG 417
    Length:417
    Mass (Da):46,532
    Last modified:February 5, 2008 - v1
    Checksum:iDEDFC97F51E621E2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000910 Genomic DNA. Translation: ABY22001.1.
    RefSeqiWP_012243709.1. NC_010168.1.
    YP_001623415.1. NC_010168.1.

    Genome annotation databases

    EnsemblBacteriaiABY22001; ABY22001; RSal33209_0245.
    GeneIDi5823479.
    KEGGirsa:RSal33209_0245.
    PATRICi23073618. VBIRenSal21953_0248.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000910 Genomic DNA. Translation: ABY22001.1 .
    RefSeqi WP_012243709.1. NC_010168.1.
    YP_001623415.1. NC_010168.1.

    3D structure databases

    ProteinModelPortali A9WLT6.
    SMRi A9WLT6. Positions 19-416.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 288705.RSal33209_0245.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABY22001 ; ABY22001 ; RSal33209_0245 .
    GeneIDi 5823479.
    KEGGi rsa:RSal33209_0245.
    PATRICi 23073618. VBIRenSal21953_0248.

    Phylogenomic databases

    eggNOGi COG0538.
    HOGENOMi HOG000019858.
    KOi K00031.
    OMAi FKDEFQR.
    OrthoDBi EOG628F3X.

    Enzyme and pathway databases

    BioCyci RSAL288705:GHX1-245-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the fish pathogen Renibacterium salmoninarum suggests reductive evolution away from an environmental Arthrobacter ancestor."
      Wiens G.D., Rockey D.D., Wu Z., Chang J., Levy R., Crane S., Chen D.S., Capri G.R., Burnett J.R., Sudheesh P.S., Schipma M.J., Burd H., Bhattacharyya A., Rhodes L.D., Kaul R., Strom M.S.
      J. Bacteriol. 190:6970-6982(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235Imported.

    Entry informationi

    Entry nameiA9WLT6_RENSM
    AccessioniPrimary (citable) accession number: A9WLT6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 5, 2008
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3