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Protein

Isocitrate dehydrogenase [NADP]

Gene

RSal33209_0245

Organism
Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei88 – 881SubstrateUniRule annotation
Binding sitei93 – 931NADPUniRule annotation
Binding sitei120 – 1201SubstrateUniRule annotation
Binding sitei143 – 1431SubstrateUniRule annotation
Sitei150 – 1501Critical for catalysisUniRule annotation
Sitei223 – 2231Critical for catalysisUniRule annotation
Metal bindingi263 – 2631Magnesium or manganeseUniRule annotation
Binding sitei271 – 2711NADPUniRule annotation
Metal bindingi286 – 2861Magnesium or manganeseUniRule annotation
Binding sitei339 – 3391NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi86 – 883NADPUniRule annotation
Nucleotide bindingi321 – 3266NADPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciRSAL288705:GHX1-245-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:RSal33209_0245Imported
OrganismiRenibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235)Imported
Taxonomic identifieri288705 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrococcaceaeRenibacterium
ProteomesiUP000002007 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi288705.RSal33209_0245.

Structurei

3D structure databases

ProteinModelPortaliA9WLT6.
SMRiA9WLT6. Positions 19-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni105 – 1117Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000019858.
KOiK00031.
OMAiVMGMYNF.
OrthoDBiEOG628F3X.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A9WLT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRTVVSEGS VAYKIKVVGP VVELDGDEMT RIIWKFIKDR LIHPYLDIDL
60 70 80 90 100
RYYDLSIQNR DATDDQVTID AANAIKEHHV GVKCATITPD EARVEEFGLK
110 120 130 140 150
KMWVSPNGTI RNILGGVVFR EPIIISNIPR LVPGWNKPII IGRHAFGDQY
160 170 180 190 200
RATNFKVPGP GKLTMSFEPA DGSEPMKFDV VSYPEAGGVA MGMYNFTDSI
210 220 230 240 250
KDFARASFAY GLQRNYPVYL STKNTILKAY DGQFKDLFQE IFDNEFKDQF
260 270 280 290 300
DAAGLTYEHR LIDDMVASAM KWEGGYVWAC KNYDGDVQSD TVAQGFGSLG
310 320 330 340 350
LMTSVLMTPD GQTVEAEAAH GTVTRHYRQH QQGKPTSTNP IASIFAWTRG
360 370 380 390 400
LMHRGKIDNT PEVIEFAETL EDVVIKTVES GKMTKDLALL VSQDQAFLTT
410
EDFLAALDEN LSARLAG
Length:417
Mass (Da):46,532
Last modified:February 5, 2008 - v1
Checksum:iDEDFC97F51E621E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000910 Genomic DNA. Translation: ABY22001.1.

Genome annotation databases

EnsemblBacteriaiABY22001; ABY22001; RSal33209_0245.
KEGGirsa:RSal33209_0245.
PATRICi23073618. VBIRenSal21953_0248.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000910 Genomic DNA. Translation: ABY22001.1.

3D structure databases

ProteinModelPortaliA9WLT6.
SMRiA9WLT6. Positions 19-416.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi288705.RSal33209_0245.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABY22001; ABY22001; RSal33209_0245.
KEGGirsa:RSal33209_0245.
PATRICi23073618. VBIRenSal21953_0248.

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000019858.
KOiK00031.
OMAiVMGMYNF.
OrthoDBiEOG628F3X.

Enzyme and pathway databases

BioCyciRSAL288705:GHX1-245-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the fish pathogen Renibacterium salmoninarum suggests reductive evolution away from an environmental Arthrobacter ancestor."
    Wiens G.D., Rockey D.D., Wu Z., Chang J., Levy R., Crane S., Chen D.S., Capri G.R., Burnett J.R., Sudheesh P.S., Schipma M.J., Burd H., Bhattacharyya A., Rhodes L.D., Kaul R., Strom M.S.
    J. Bacteriol. 190:6970-6982(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235Imported.

Entry informationi

Entry nameiA9WLT6_RENSM
AccessioniPrimary (citable) accession number: A9WLT6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: July 22, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.