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A9WLM4 (A9WLM4_RENSM) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase HAMAP MF_00183
Short name=DXP reductoisomerase HAMAP MF_00183
EC=1.1.1.267 HAMAP MF_00183
Alternative name(s):
1-deoxyxylulose-5-phosphate reductoisomerase HAMAP MF_00183
2-C-methyl-D-erythritol 4-phosphate synthase HAMAP MF_00183
Gene names
Name:dxr HAMAP MF_00183
Ordered Locus Names:RSal33209_0635
OrganismRenibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235) [Complete proteome] [HAMAP] EMBL ABY22382.1
Taxonomic identifier288705 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Renibacterium

Protein attributes

Sequence length412 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00183 SAAS SAAS003821

Catalytic activity

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH. HAMAP MF_00183 SAAS SAAS003821

Cofactor

Divalent cation By similarity. HAMAP MF_00183 SAAS SAAS003821

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6. HAMAP MF_00183 SAAS SAAS003821

Sequence similarities

Belongs to the DXR family. HAMAP MF_00183

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding27 – 6135NADP By similarity HAMAP MF_00183

Sites

Metal binding1741Divalent metal cation By similarity HAMAP MF_00183
Metal binding1761Divalent metal cation By similarity HAMAP MF_00183
Metal binding2451Divalent metal cation By similarity HAMAP MF_00183
Binding site1511Substrate By similarity HAMAP MF_00183
Binding site1761Substrate By similarity HAMAP MF_00183
Binding site2001Substrate By similarity HAMAP MF_00183
Binding site2231Substrate By similarity HAMAP MF_00183
Binding site2451Substrate By similarity HAMAP MF_00183

Sequences

Sequence LengthMass (Da)Tools
A9WLM4 [UniParc].

Last modified February 5, 2008. Version 1.
Checksum: CA19075F67E34226

FASTA41243,016
        10         20         30         40         50         60 
MSRERFRLRD TGAMSASNNA SRRVVILGST GSIGTQALDV IGRSFTDDGQ PLFDVVGLSA 

        70         80         90        100        110        120 
GGANLELLAE QAAIVRPLAI GIAHGDPAVL AQAIASLAPG YAPQIESGPT AASLIAALDA 

       130        140        150        160        170        180 
DVVLNGITGS IGLAPTLAAL KAGSTLALAN KESLIVGGQL VKDAASAGQL VPVDSEHSAI 

       190        200        210        220        230        240 
AQCLRAGNKL DVDKLILTAS GGPFRGRKLH ELLGITPAEA LNHPTWDMGL MVTTNSATLV 

       250        260        270        280        290        300 
NKGLEAIEAH LLFDIPLDKI EVVVHPQSVV HSMVQFVDGS TIAQVSPPDM RLPIALGLAW 

       310        320        330        340        350        360 
PERVEHAIQP CDWTKATQLT FEPLDAIAFP AVDLAKDAAK QGGTHPAVFN AANEEAVLAF 

       370        380        390        400        410 
HDGRISFLDI VDTVQKVLSE HSADATLSLA AVLDAESWAR TRTRERLAQL SE

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References

[1]"Genome sequence of the fish pathogen Renibacterium salmoninarum suggests reductive evolution away from an environmental Arthrobacter ancestor."
Wiens G.D., Rockey D.D., Wu Z., Chang J., Levy R., Crane S., Chen D.S., Capri G.R., Burnett J.R., Sudheesh P.S., Schipma M.J., Burd H., Bhattacharyya A., Rhodes L.D., Kaul R., Strom M.S.
J. Bacteriol. 190:6970-6982(2008) [PubMed: 18723615] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33209 / DSM 20767 / JCM 11484 / NBRC 15589 / NCIMB 2235.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000910 Genomic DNA. Translation: ABY22382.1.
RefSeqYP_001623796.1. NC_010168.1.

3D structure databases

ProteinModelPortalA9WLM4.
SMRA9WLM4. Positions 21-409.
ModBaseSearch...

Protein-protein interaction databases

STRINGA9WLM4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5823626.
GenomeReviewsGene locus RSal33209_0635 in contig CP000910_GR.
KEGGrsa:RSal33209_0635.
PATRIC23074438. VBIRenSal21953_0649.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG430762.
OMAIHSMVEY.
ProtClustDBPRK05447.

Enzyme and pathway databases

BioCycRSAL288705:RSAL33209_0635-MONOMER.

Family and domain databases

HAMAPMF_00183. DXP_reductoisom.
[Tree]
InterProIPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00099.
PfamPF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
[Graphical view]
PIRSFPIRSF006205. Dxp_reductismrs. 1 hit.
TIGRFAMsTIGR00243. Dxr. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA9WLM4_RENSM
AccessionPrimary (citable) accession number: A9WLM4
Entry history
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info