Reviewed, UniProtKB/Swiss-Prot A9WKW2 (IOLG_RENSM)

Names and origin

Protein names

Recommended name:
    Inositol 2-dehydrogenase
    EC=1.1.1.18
Alternative name(s):
    Myo-inositol 2-dehydrogenase
      Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	RSal33209_0365

Organism

Renibacterium salmoninarum (strain ATCC 33209 / DSM 20767 / IFO 15589) [Complete proteome] [HAMAP]

Taxonomic identifier

288705 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Micrococcaceae › Renibacterium

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity.
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 331	331	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_0000352585

Sequences

	Sequence		Length	Mass (Da)
	A9WKW2-1 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 5FE807A7AF86AA4C	FASTA	331	35,267
	10 20 30 40 50 60 MNVAVIGAGR MGADHVRRLH ESINNATVAA VVDIDLDRAK AATEGTGALA VASLAEAFAV 70 80 90 100 110 120 EGVNAVLIAT PGFLHEEALY QALQRDVPIL CEKPMTPDAA SAWRVVQAEV ALGRQRIQVG 130 140 150 160 170 180 FMRQFDAGYQ SLKSEIEAGA AGSLLMLHCA NRNASTLADF TEPMLINDSV VHEFDAIRFF 190 200 210 220 230 240 TGEEITSVQV QVQVQVQVQV QVQRGKRSSL APEGISDPQH VLIETESGIL ADVEIFVNAR 250 260 270 280 290 300 YGYEVATQAV FENGVRSIGA GEVTPSFIER FAAAYDAEVQ AWVDAALHGE IGGPSAWDGY 310 320 330 ATAACCEAGV AAQRSGQRTA VVLAAKPELY R

References

[1]

"The genome sequence of Renibacterium salmoninarum ATCC 33209 suggests reductive genome evolution from environmental Arthrobacter." Wiens G.D., Rockey D.R., Wu Z., Gillett W., Hayden H., Crane S., Chen D.S., Capri G.R., Burnett J.R., Ponnerassery S., Schipma M.J., Burd H., Bhattacharyya A., Kaul R., Rhodes L.D., Strom M.S. Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000910 Genomic DNA. Translation: ABY22120.1.
RefSeq	YP_001623534.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5822951.
GenomeReviews	Gene locus RSal33209_0365 in contig CP000910_GR.
KEGG	rsa:RSal33209_0365.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	HESINNA.
Family and domain databases
HAMAP	MF_01671. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_RENSM

Accession

Primary (citable) accession number: A9WKW2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	February 5, 2008
Last modified:	November 3, 2009
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)