A9WKG4 (ARGB_CHLAA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	Caur_3407

Organism

Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)

Taxonomic identifier

324602 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Chloroflexales › Chloroflexaceae › Chloroflexus

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_B
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00082_B.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetylglutamate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	Acetylglutamate kinase HAMAP MF_00082_B		PRO_0000335618
Regions
	Region	40 – 41	2	Substrate binding By similarity
Sites
	Binding site	62	1	Substrate By similarity
	Binding site	158	1	Substrate By similarity
	Site	8	1	Transition state stabilizer By similarity
	Site	217	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	A9WKG4 [UniParc]. Last modified February 5, 2008. Version 1. Checksum: 5CBEBB8369118AAF	FASTA	254	25,905
	10 20 30 40 50 60 MTTISVIKVS GHELDDPTFL GGLTAALRGF QQPLVLVHGG GKEISAAVER AGLQIEFVDG 70 80 90 100 110 120 LRVTSPAVMD IMQMVVCGTI NKRIVTALVN AGVKAIGLSG LDLGLLRCEP YRPAGRDLGR 130 140 150 160 170 180 VGEVTAVDGA ALLHLLALGW MPVIAPVALG ATDGLSYNVN ADMVAEAVAG ALAGAELVFV 190 200 210 220 230 240 SNVPGVLVDG RVVPALTPAA VEELIANGVI SGGMIPKVRA ALAALQRGAS SVRIVNLAGL 250 HDGGTRFTHG ELSE

References

[1]

"Complete sequence of Chloroflexus aurantiacus J-10-fl." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Mikhailova N., Pierson B.K., Blankenship R.E., Richardson P. Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29366 / DSM 635 / J-10-fl.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000909 Genomic DNA. Translation: ABY36592.1.
RefSeq	YP_001636981.1. NC_010175.1.
3D structure databases
ProteinModelPortal	A9WKG4.
ModBase	Search...
Protein-protein interaction databases
STRING	A9WKG4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5825209.
GenomeReviews	Gene locus Caur_3407 in contig CP000909_GR.
KEGG	cau:Caur_3407.
PATRIC	21418192. VBIChlAur28763_3835.
Phylogenomic databases
HOGENOM	HBG497643.
OMA	CNINVEK.
PhylomeDB	A9WKG4.
ProtClustDB	CLSK975146.
Family and domain databases
HAMAP	MF_00082_B. ArgB_B. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00930.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_CHLAA

Accession

Primary (citable) accession number: A9WKG4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 5, 2008
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program